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The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

Journal of molecular biology, 2020-03, Vol.432 (5), p.1367-1394

Gilon, Patrick

2020

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Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Nature communications, 2017-03, Vol.8 (1), p.14733-16, Article 14733

2017

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GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function

Cell reports (Cambridge), 2023-11, Vol.42 (11), p.113326-113326, Article 113326

2023

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Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms

Molecular metabolism (Germany), 2022-07, Vol.61, p.101495-101495, Article 101495

2022

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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

PloS one, 2012-07, Vol.7 (7), p.e39722-e39722

2012

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AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes

American journal of physiology. Heart and circulatory physiology, 2014-10, Vol.307 (8), p.H1120-H1133

2014

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Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers

Diabetes (New York, N.Y.), 2018-11, Vol.67 (11), p.2239-2253

2018

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Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation

Genome research, 2011-01, Vol.21 (1), p.95-105

2011

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Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion

International journal of molecular sciences, 2023-05, Vol.24 (11), p.9136

2023

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Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

Scientific reports, 2017-01, Vol.7 (1), p.41166, Article 41166

2017

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Loss of high-frequency glucose-induced Ca²⁺ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5⁻/⁻ mice

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (11), p.5208-5213

2010

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Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

Diabetologia, 2019-12, Vol.62 (12), p.2273-2286

2019

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KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin

Molecular metabolism (Germany), 2021-11, Vol.53, p.101268-101268, Article 101268

2021

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How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?

PloS one, 2017-08, Vol.12 (8), p.e0181651-e0181651

2017

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Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells

Diabetologia, 2016-09, Vol.59 (9), p.1855-1859

Gilon, Patrick

2016

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Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]

Molecular metabolism (Germany), 2024-05, Vol.83, p.101935-101935, Article 101935

2024

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Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

Molecular metabolism (Germany), 2017-11, Vol.6 (11), p.1407-1418

2017

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SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Molecular metabolism (Germany), 2020-12, Vol.42, p.101071-101071, Article 101071

2020

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UCP2 Regulates the Glucagon Response to Fasting and Starvation

Diabetes (New York, N.Y.), 2013-05, Vol.62 (5), p.1623-1633

2013

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Glucose regulation of glucagon secretion

Diabetes research and clinical practice, 2014-01, Vol.103 (1), p.1-10

2014

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Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?

Diabetes and Metabolism Journal, 2015, 39(1), 147, pp.27-30

2015

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Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

Molecular metabolism (Germany), 2016-05, Vol.5 (5), p.366-378

2016

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In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Frontiers in cell and developmental biology, 2022-08, Vol.10, p.967765-967765

2022

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Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

Diabetes (New York, N.Y.), 2009-02, Vol.58 (2), p.412-421

2009

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Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

Diabetes (New York, N.Y.), 2002-02, Vol.51 (suppl 1), p.S144-S151

2002

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The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function

Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes

Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of KATP Channel Blockers

Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation

Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

Loss of high-frequency glucose-induced Ca²⁺ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5⁻/⁻ mice

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin

How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?

Cocaine- and amphetamine-regulated transcript: a novel regulator of energy homeostasis expressed in a subpopulation of pancreatic islet cells

Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

UCP2 Regulates the Glucagon Response to Fasting and Starvation

Glucose regulation of glucagon secretion

Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?

Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

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