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Inhibitors of leucine-rich repeat kinase 2 (LRRK2): progress and promise for the treatment of Parkinson's disease

Current topics in medicinal chemistry, 2015-01, Vol.15 (10), p.927

Gilligan, Paul J

2015

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Recent progress in drug discovery for Parkinson's disease

Current topics in medicinal chemistry, 2015, Vol.15 (10), p.905

Gilligan, Paul J

2015

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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7226-7242

2020

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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.293

2004

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Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126949, Article 126949

2020

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Novel phenylalanine derived diamides as Factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.472-478

2016

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Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies

Journal of medicinal chemistry, 1999-03, Vol.42 (5), p.819-832

1999

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Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3084-3092

2009

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Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1641-1660

2000

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Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.590-595

2015

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Design, Synthesis, and Biological Evaluation of 1,2,3,7-Tetrahydro-6H-purin-6-one and 3,7-Dihydro-1H-purine-2,6-dione Derivatives as Corticotropin-Releasing Factor1 Receptor Antagonists

Journal of medicinal chemistry, 2004-09, Vol.47 (19), p.4741-4754

2004

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8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3073-3083

2009

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Corticotropin-releasing factor receptor antagonists

Expert opinion on therapeutic patents, 2006-07, Vol.16 (7), p.913-924

Gilligan, Paul J

2006

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Synthesis and evaluation of imidazo[1,5- a]pyrazines as corticotropin releasing hormone receptor ligands

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.291-294

2002

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Synthesis of 6-Substituted Imidazo[4,5-d]pyridazin-7-ones

Heterocycles, 2003-06, Vol.60 (6), p.1329

2003

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Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.934-937

2006

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4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF1 Receptor Antagonist

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.449-456

2000

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Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.4986-4989

2012

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The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Psychopharmacologia, 2002-12, Vol.165 (1), p.86-92

2002

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Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

Psychopharmacologia, 2005-04, Vol.178 (4), p.410-419

2005

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Pyrazolo-[1,5- a]-1,3,5-triazine corticotropin-Releasing factor (CRF) receptor ligands

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.4093-4102

2003

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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Journal of medicinal chemistry, 2007-05, Vol.50 (9), p.2269-2272

2007

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Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

Journal of medicinal chemistry, 2004-11, Vol.47 (23), p.5783-5790

2004

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Inhibitors of leucine-rich repeat kinase 2 (LRRK2): progress and promise for the treatment of Parkinson's disease

Recent progress in drug discovery for Parkinson's disease

Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species

Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats

Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa

Novel phenylalanine derived diamides as Factor XIa inhibitors

Non-Peptide Corticotropin-Releasing Hormone Antagonists: Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines

Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies

Synthesis, Corticotropin-Releasing Factor Receptor Binding Affinity, and Pharmacokinetic Properties of Triazolo-, Imidazo-, and Pyrrolopyrimidines and -pyridines

Synthesis and Structure−Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists

Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

Design, Synthesis, and Biological Evaluation of 1,2,3,7-Tetrahydro-6H-purin-6-one and 3,7-Dihydro-1H-purine-2,6-dione Derivatives as Corticotropin-Releasing Factor1 Receptor Antagonists

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists

Corticotropin-releasing factor receptor antagonists

Synthesis and evaluation of imidazo[1,5- a]pyrazines as corticotropin releasing hormone receptor ligands

Synthesis of 6-Substituted Imidazo[4,5-d]pyridazin-7-ones

Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF1 Receptor Antagonist

Synthesis and structure–activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

The CRF1 receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

Effects of CRF1 receptor antagonists and benzodiazepines in the Morris water maze and delayed non-matching to position tests

Pyrazolo-[1,5- a]-1,3,5-triazine corticotropin-Releasing factor (CRF) receptor ligands

Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational Modeling

Synthesis, Structure−Activity Relationships, and in Vivo Properties of 3,4-Dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as Corticotropin-Releasing Factor-1 Receptor Antagonists

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