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Brostallicin (PNU-166196) - a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells

British journal of cancer, 2003-10, Vol.89 (8), p.1559-1565

2003

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Blood glutathione as a surrogate marker of cancer tissue glutathione S-transferase activity in non-small cell lung cancer and squamous cell carcinoma of the head and neck

European journal of cancer (1990), 2003-05, Vol.39 (7), p.1019-1029

2003

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Estimation of the haematological toxicity of minor groove alkylators using tests on human cord blood cells

British journal of cancer, 1997, Vol.75 (6), p.878-883

1997

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α-Bromoacryloyl derivative of distamycin A (PNU 151807) : a new non-covalent minor groove DNA binder with antineoplastic activity

British journal of cancer, 1999-06, Vol.80 (7), p.991-997

1999

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Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation

European journal of cancer (1990), 2003-03, Vol.39 (5), p.675-683

2003

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Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

Clinical cancer research, 2005-02, Vol.11 (4), p.1608-1617

2005

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333 POSTER Effectiveness of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human osteosarcoma and melanoma tumours

European journal of cancer supplements, 2008, Vol.6 (12), p.106-106

2008

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Ongoing phase I and II studies of novel anthracyclines

Cardiovascular toxicology, 2007-06, Vol.7 (2), p.75-79

2007

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Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners

Journal of medicinal chemistry, 2004-05, Vol.47 (10), p.2611-2623

2004

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Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin

British journal of cancer, 1986-09, Vol.54 (3), p.515-518

1986

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Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione

Cancer research (Chicago, Ill.), 2002-04, Vol.62 (8), p.2332-2336

2002

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Enhancement of in Vivo Antitumor Activity of Classical Anticancer Agents by Combination with the New, Glutathione-Interacting DNA Minor Groove-Binder, Brostallicin

Clinical cancer research, 2003-11, Vol.9 (14), p.5402-5408

2003

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Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies

Bioorganic & medicinal chemistry, 2004-07, Vol.12 (14), p.3911-3921

2004

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Synthesis and Antitumor Activity of New Benzoheterocyclic Derivatives of Distamycin A

Journal of medicinal chemistry, 2000-07, Vol.43 (14), p.2675-2684

2000

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Brostallicin: a new concept in minor groove DNA binder development

Anti-cancer drugs, 2004-01, Vol.15 (1), p.1-6

2004

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Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine)

British journal of cancer, 1995-12, Vol.72 (6), p.1504-1508

1995

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L1210 cells selected for resistance to methoxymorpholinyl doxorubicin appear specifically resistant to this class of morpholinyl derivatives

British journal of cancer, 1994-02, Vol.69 (2), p.315-319

1994

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In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin : Role of cytochrome P450 3A

Cancer research (Chicago, Ill.), 2000-06, Vol.60 (12), p.3232-3238

2000

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Phase I/II trial of nemorubicin hydrochloride in combination with cisplatin is supported by new preclinical evidences of its mechanism of action

Journal of clinical oncology, 2006-06, Vol.24 (18_suppl), p.14116-14116

2006

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500 POSTER Investigating the role of Nucleotide Excision Repair (NER) in the antitumor activity of Nemorubicin

European journal of cancer supplements, 2006-11, Vol.4 (12), p.152-152

2006

Volltextzugriff (PDF)

4-Demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin (PNU-159548): A promising new candidate for chemotherapeutic treatment of osteosarcoma patients

European journal of cancer (1990), 2005-09, Vol.41 (14), p.2184-2195

2005

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Cytotoxic halogenoacrylic derivatives of distamycin A

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1269-1272

2000

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Cytotoxic α-bromoacrylic derivatives of distamycin analogues modified at the amidino moiety

Bioorganic & medicinal chemistry letters, 2000-06, Vol.10 (11), p.1273-1276

2000

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Sequence-specific DNA alkylation of novel tallimustine derivatives

Anti-cancer drug design, 1998-04, Vol.13 (3), p.193

1998

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Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity

Bioorganic & medicinal chemistry, 1999-02, Vol.7 (2), p.251-262

1999

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Brostallicin (PNU-166196) - a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells

Blood glutathione as a surrogate marker of cancer tissue glutathione S-transferase activity in non-small cell lung cancer and squamous cell carcinoma of the head and neck

Estimation of the haematological toxicity of minor groove alkylators using tests on human cord blood cells

α-Bromoacryloyl derivative of distamycin A (PNU 151807) : a new non-covalent minor groove DNA binder with antineoplastic activity

Predicting the maximum-tolerated dose of PNU-159548 (4-demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin) in humans using CFU-GM clonogenic assays and prospective validation

Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

333 POSTER Effectiveness of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human osteosarcoma and melanoma tumours

Ongoing phase I and II studies of novel anthracyclines

Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners

Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin

Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione

Enhancement of in Vivo Antitumor Activity of Classical Anticancer Agents by Combination with the New, Glutathione-Interacting DNA Minor Groove-Binder, Brostallicin

Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: design, synthesis, molecular modeling and antitumor activity studies

Synthesis and Antitumor Activity of New Benzoheterocyclic Derivatives of Distamycin A

Brostallicin: a new concept in minor groove DNA binder development

Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine)

L1210 cells selected for resistance to methoxymorpholinyl doxorubicin appear specifically resistant to this class of morpholinyl derivatives

In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin : Role of cytochrome P450 3A

Phase I/II trial of nemorubicin hydrochloride in combination with cisplatin is supported by new preclinical evidences of its mechanism of action

500 POSTER Investigating the role of Nucleotide Excision Repair (NER) in the antitumor activity of Nemorubicin

4-Demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin (PNU-159548): A promising new candidate for chemotherapeutic treatment of osteosarcoma patients

Cytotoxic halogenoacrylic derivatives of distamycin A

Cytotoxic α-bromoacrylic derivatives of distamycin analogues modified at the amidino moiety

Sequence-specific DNA alkylation of novel tallimustine derivatives

Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity

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