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PKD1 interacts with PKD2 through a probable coiled-coil domain

Nature genetics, 1997-06, Vol.16 (2), p.179-183

1997

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In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model

PloS one, 2023-08, Vol.18 (8), p.e0289778

2023

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Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

Journal of the American Society of Nephrology, 2010-03, Vol.21 (3), p.489-497

2010

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The mTOR Pathway Is Regulated by Polycystin-1, and Its Inhibition Reverses Renal Cystogenesis in Polycystic Kidney Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (14), p.5466-5471

2006

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Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Nature communications, 2014-11, Vol.5 (1), p.5482-5482, Article 5482

2014

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Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

EBioMedicine, 2016-03, Vol.5 (C), p.183-192

2016

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mTOR Inhibitors in Polycystic Kidney Disease

The New England journal of medicine, 2010-08, Vol.363 (9), p.879-881

2010

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Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

Cell reports (Cambridge), 2014-05, Vol.7 (3), p.634-644

2014

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

Nature (London), 2000-12, Vol.408 (6815), p.990-994

2000

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TRPP2 and TRPV4 form a polymodal sensory channel complex

The Journal of cell biology, 2008-08, Vol.182 (3), p.437-447

2008

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The pathobiology of polycystic kidney disease from a metabolic viewpoint

Nature reviews. Nephrology, 2019-12, Vol.15 (12), p.735

2019

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Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Molecular and Cellular Biology, 2009-05, Vol.29 (9), p.2359-2371

2009

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Cleavage of Polycystin-1 Requires the Receptor for Egg Jelly Domain and Is Disrupted by Human Autosomal-Dominant Polycystic Kidney Disease 1-Associated Mutations

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (26), p.16981-16986

2002

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

Cell, 2002-04, Vol.109 (2), p.157-168

2002

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Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier

PLoS genetics, 2012-11, Vol.8 (11), p.e1003053

2012

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Linking cilia to Wnts

Nature genetics, 2005-05, Vol.37 (5), p.455-457

Germino, Gregory G

2005

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Polycystin 2 Interacts with Type I Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+ Signaling

The Journal of biological chemistry, 2005-12, Vol.280 (50), p.41298-41306

2005

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Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function

Molecular biology of the cell, 2014-10, Vol.25 (19), p.2919-2933

2014

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PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene, Encodes a Novel Large Protein Containing Multiple Immunoglobulin-Like Plexin-Transcription–Factor Domains and Parallel Beta-Helix 1 Repeats

American journal of human genetics, 2002-05, Vol.70 (5), p.1305-1317

2002

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Role of polycystins in renal tubulogenesis

Trends in cell biology, 2003-09, Vol.13 (9), p.484-492

2003

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The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I

Cell, 1996-12, Vol.87 (6), p.979-987

1996

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Pkd1 and Pkd2 are required for normal placental development

PloS one, 2010-09, Vol.5 (9), p.e12821

2010

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Comprehensive genomic analysis of PKHD1 mutations in ARPKD cohorts

Journal of medical genetics, 2005-04, Vol.42 (4), p.336-349

2005

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Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (47), p.18688-18693

2007

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Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

Journal of the American Society of Nephrology, 2009-11, Vol.20 (11), p.2389-2402

2009

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PKD1 interacts with PKD2 through a probable coiled-coil domain

In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

The mTOR Pathway Is Regulated by Polycystin-1, and Its Inhibition Reverses Renal Cystogenesis in Polycystic Kidney Disease

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

mTOR Inhibitors in Polycystic Kidney Disease

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

TRPP2 and TRPV4 form a polymodal sensory channel complex

The pathobiology of polycystic kidney disease from a metabolic viewpoint

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

Cleavage of Polycystin-1 Requires the Receptor for Egg Jelly Domain and Is Disrupted by Human Autosomal-Dominant Polycystic Kidney Disease 1-Associated Mutations

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier

Linking cilia to Wnts

Polycystin 2 Interacts with Type I Inositol 1,4,5-Trisphosphate Receptor to Modulate Intracellular Ca2+ Signaling

Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function

PKHD1, the Polycystic Kidney and Hepatic Disease 1 Gene, Encodes a Novel Large Protein Containing Multiple Immunoglobulin-Like Plexin-Transcription–Factor Domains and Parallel Beta-Helix 1 Repeats

Role of polycystins in renal tubulogenesis

The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I

Pkd1 and Pkd2 are required for normal placental development

Comprehensive genomic analysis of PKHD1 mutations in ARPKD cohorts

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

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