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The Prostaglandin Analogs, Misoprostol and SC-46275, Potently Inhibit Cytokine Release from Activated Human Monocytes

Immunopharmacology and immunotoxicology, 1997-01, Vol.19 (2), p.165-174

1997

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SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog

The Journal of pharmacology and experimental therapeutics, 1991-12, Vol.259 (3), p.1004

1991

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Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3087-3097

1993

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Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase

Journal of medicinal chemistry, 2000-02, Vol.43 (4), p.721-735

2000

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Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost

Journal of medicinal chemistry, 1992-02, Vol.35 (4), p.694-704

1992

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Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2784-2793

1990

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Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation

Inflammation, 1992-12, Vol.16 (6), p.623-629

1992

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Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/Ring-Closing Metathesis Reactions

Organic letters, 2005-07, Vol.7 (15), p.3183-3186

2005

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Characterization of prostaglandin E receptors in canine small intestine using [3H] prostaglandin E1 binding

Prostaglandins, 1992-12, Vol.44 (6), p.579-595

1992

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Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.151

1994

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Synthesis of fused triazolo-imidazole derivatives by sequential van Leusen/alkyne–azide cycloaddition reactions

Tetrahedron letters, 2005-12, Vol.46 (52), p.9053-9056

2005

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18-Cycloalkyl analogs of enisoprost

Journal of medicinal chemistry, 1989-05, Vol.32 (5), p.1001-1006

1989

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Synthesis and gastrointestinal pharmacology of a 3E,5Z diene analog of misoprostol

Journal of medicinal chemistry, 1987-01, Vol.30 (1), p.193-197

1987

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Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions

Tetrahedron letters, 2005-12, Vol.46 (52), p.9049-9052

2005

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Synthesis and gastric antisecretory properties of .alpha.-chain diene derivatives of misoprostol

Journal of medicinal chemistry, 1986-07, Vol.29 (7), p.1195-1201

1986

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Redox glycosidation: a new strategy for disaccharide synthesis

Journal of the American Chemical Society, 1989-02, Vol.111 (4), p.1392-1396

1989

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Stabilization of a prostaglandin tertiary allylic alcohol system by fluorine: synthesis, acid stability studies and pharmacology of a 16-fluoromethyl analog of SC-46275

Bioorganic & medicinal chemistry letters, 1992-12, Vol.2 (12), p.1761-1766

1992

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Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3383

2002

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Alpha chain unsaturated derivatives of misoprostol

Prostaglandins, 1987, Vol.33, p.17-28

1987

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Application of (chloromethyl)aluminum 2-(2-propenyl)anilide in the conversion of .gamma.- and .delta.-lactones into protected hydroxy acids

Journal of organic chemistry, 1989-07, Vol.54 (14), p.3321-3324

1989

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Antisecretory, mucosal-protective, and diarrheagenic activity of a novel synthetic prostaglandin, SC-46275, in the rat

Drug development research, 1991, Vol.23 (4), p.349-358

1991

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Chemistry and structure-activity relationship of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin

Journal of medicinal chemistry, 1990, Vol.33 (10), p.2784-2793

1990

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Synthesis and gastric antisecretory properties of 4,5 unsaturated derivatives of 15-deoxy-16-hydroxy-16-methylprostaglandin E1

Journal of medicinal chemistry, 1983-06, Vol.26 (6), p.786-790

1983

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The Prostaglandin Analogs, Misoprostol and SC-46275, Potently Inhibit Cytokine Release from Activated Human Monocytes

SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog

Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach

Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase

Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost

Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin

Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation

Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/Ring-Closing Metathesis Reactions

Characterization of prostaglandin E receptors in canine small intestine using [3H] prostaglandin E1 binding

Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem

1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel

Synthesis of fused triazolo-imidazole derivatives by sequential van Leusen/alkyne–azide cycloaddition reactions

18-Cycloalkyl analogs of enisoprost

Synthesis and gastrointestinal pharmacology of a 3E,5Z diene analog of misoprostol

Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions

Synthesis and gastric antisecretory properties of .alpha.-chain diene derivatives of misoprostol

Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase

Redox glycosidation: a new strategy for disaccharide synthesis

Stabilization of a prostaglandin tertiary allylic alcohol system by fluorine: synthesis, acid stability studies and pharmacology of a 16-fluoromethyl analog of SC-46275

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase

Alpha chain unsaturated derivatives of misoprostol

Application of (chloromethyl)aluminum 2-(2-propenyl)anilide in the conversion of .gamma.- and .delta.-lactones into protected hydroxy acids

Antisecretory, mucosal-protective, and diarrheagenic activity of a novel synthetic prostaglandin, SC-46275, in the rat

Chemistry and structure-activity relationship of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogues of enisoprost. Identification of a promising new antiulcer prostaglandin

Synthesis and gastric antisecretory properties of 4,5 unsaturated derivatives of 15-deoxy-16-hydroxy-16-methylprostaglandin E1

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