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Bicyclic α‑Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3610-3633

2020

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Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I 1 - and I 2 -imidazoline drugs

Journal of psychopharmacology (Oxford), 2015-09, Vol.29 (9), p.996-1012

2015

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Effects of I 2 -imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I 1 -IR and μ-opioid receptor proteins and modulation of associated signalling pathways

Neurochemistry international, 2017-09, Vol.108, p.169

2017

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Exploring the antidepressant-like potential of the selective I 2 -imidazoline receptor ligand LSL 60101 in adult male rats

Pharmacological reports, 2021-02, Vol.73 (1), p.288

2021

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Behavioral and Cognitive Improvement Induced by Novel Imidazoline I 2 Receptor Ligands in Female SAMP8 Mice

Neurotherapeutics, 2019-04, Vol.16 (2), p.416

2019

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Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α(2)-adrenoceptors and extracellular signal-regulated kinases

Journal of psychopharmacology (Oxford), 2011-12, Vol.25 (12), p.1691-1702

2011

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Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration

Psychopharmacology, 2016-08, Vol.233 (15-16), p.2955-2971

2016

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Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress

International journal of molecular sciences, 2023-01, Vol.24 (3), p.2303

2023

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Imidazoline Receptor System: The Past, the Present, and the Future

Pharmacological reviews, 2020-01, Vol.72 (1), p.50-79

2020

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Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice

Journal of psychopharmacology (Oxford), 2016-09, Vol.30 (9), p.875-886

2016

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Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

Psychopharmacologia, 2009-10, Vol.206 (2), p.313-324

2009

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Brain α2‐adrenoceptors in monoamine‐depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA

British journal of pharmacology, 2001-04, Vol.132 (7), p.1467-1476

2001

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Optimization and pharmacological characterization of receptor‐mediated Gi/o activation in postmortem human prefrontal cortex

Basic & clinical pharmacology & toxicology, 2019-06, Vol.124 (6), p.649-659

2019

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Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain

Journal of psychopharmacology (Oxford), 2013-02, Vol.27 (2), p.123-134

2013

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Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex

Neuropharmacology, 2015-02, Vol.89, p.204-214

2015

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Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

Molecular neurodegeneration, 2017-03, Vol.12 (1), p.26, Article 26

2017

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Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment

The international journal of neuropsychopharmacology, 2012-06, Vol.15 (5), p.573-588

2012

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Downregulation of Neuronal cdk5 p35 in Opioid Addicts and Opiate-Treated Rats: Relation to Neurofilament Phosphorylation

Neuropsychopharmacology, 2003-05, Vol.28 (5), p.947-955

2003

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Regulation of cannabinoid CB1 and CB2 receptors, neuroprotective mTOR and pro-apoptotic JNK1/2 kinases in postmortem prefrontal cortex of subjects with major depressive disorder

Journal of affective disorders, 2020-11, Vol.276, p.626-635

2020

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Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking

Addiction biology, 2013-07, Vol.18 (4), p.633-643

2013

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Dysregulation of IRAS/nischarin and other potential I 1 -imidazoline receptors in major depression postmortem brain: Downregulation of basal contents by antidepressant drug treatments

Journal of affective disorders, 2017-01, Vol.208, p.646-652

2017

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5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts

Pharmacological reports, 2021-08, Vol.73 (4), p.1155-1163

2021

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Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABA A receptor

Progress in neuro-psychopharmacology & biological psychiatry, 2019-01, Vol.88, p.121

2019

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Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

The international journal of neuropsychopharmacology, 2013-04, Vol.16 (3), p.683-689

2013

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Upregulation of IRAS/nischarin (I1-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers

Neurochemistry international, 2017-09, Vol.108, p.282-286

2017

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Bicyclic α‑Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease

Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I 1 - and I 2 -imidazoline drugs

Effects of I 2 -imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I 1 -IR and μ-opioid receptor proteins and modulation of associated signalling pathways

Exploring the antidepressant-like potential of the selective I 2 -imidazoline receptor ligand LSL 60101 in adult male rats

Behavioral and Cognitive Improvement Induced by Novel Imidazoline I 2 Receptor Ligands in Female SAMP8 Mice

Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α(2)-adrenoceptors and extracellular signal-regulated kinases

Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration

Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress

Imidazoline Receptor System: The Past, the Present, and the Future

Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

Brain α2‐adrenoceptors in monoamine‐depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA

Optimization and pharmacological characterization of receptor‐mediated Gi/o activation in postmortem human prefrontal cortex

Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain

Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex

Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment

Downregulation of Neuronal cdk5 p35 in Opioid Addicts and Opiate-Treated Rats: Relation to Neurofilament Phosphorylation

Regulation of cannabinoid CB1 and CB2 receptors, neuroprotective mTOR and pro-apoptotic JNK1/2 kinases in postmortem prefrontal cortex of subjects with major depressive disorder

Substituting a long-acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking

Dysregulation of IRAS/nischarin and other potential I 1 -imidazoline receptors in major depression postmortem brain: Downregulation of basal contents by antidepressant drug treatments

5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts

Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABA A receptor

Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

Upregulation of IRAS/nischarin (I1-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers

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