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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects

Leukemia, 2013-02, Vol.27 (2), p.430-440

2013

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In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone

Leukemia, 2015-03, Vol.29 (3), p.705-714

2015

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The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repair

Leukemia, 2009-12, Vol.23 (12), p.2265-2274

2009

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Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

Leukemia, 2009-08, Vol.23 (8), p.1515-1527

2009

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P848: TINOSTAMUSTINE (EDO‐S101), AN ALKYLATOR AND HISTONE DEACETYLASE INHIBITOR, ENHANCES THE EFFICACY OF DARATUMUMAB IN PRECLINICAL MODELS OF MULTIPLE MYELOMA

HemaSphere, 2022-06, Vol.6 (Suppl), p.742-743

2022

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Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study

Biochimica et biophysica acta, 2007-06, Vol.1773 (6), p.880-890

2007

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Preclinical Antimyeloma Activity of EDO-S101

Clinical lymphoma, myeloma and leukemia, 2015-09, Vol.15, p.e218-e218

2015

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Filanesib (ARRY-520) Demonstrates Potent and Rapid Activity in Preclinical Models of MM, Dependent on Bcl-2 Family Expression, and Synergistic with Dexamethasone and IMiDs

Clinical lymphoma, myeloma and leukemia, 2015-09, Vol.15, p.e213-e214

2015

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The novel pan-PIM kinase inhibitor, LGH447, shows dual antitumoral and bone antiresorptive effect in multiple myeloma and synergizes with standard-of-care treatments

Clinical lymphoma, myeloma and leukemia, 2015-09, Vol.15, p.e222-e222

2015

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In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

Haematologica (Roma), 2010-05, Vol.95 (5), p.794-803

2010

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Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

Journal of molecular endocrinology, 2001-08, Vol.27 (1), p.31-41

2001

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La autoridad política y el poder de las letras en el Siglo de Oro

1, 2013

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CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

Haematologica (Roma), 2012-07, Vol.97 (7), p.1110-1114

2012

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Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients

Clinical cancer research, 2004-06, Vol.10 (11), p.3639-3649

2004

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Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

Molecular endocrinology (Baltimore, Md.), 2000-06, Vol.14 (6), p.848-862

2000

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The Hybrid Molecule, Edo-S101, Impairs Double Strand Breaks Repair in Multiple Myeloma and Synergizes with Bortezomib and Dexamethasone

Blood, 2015-12, Vol.126 (23), p.5354-5354

2015

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The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

Haematologica (Roma), 2008-01, Vol.93 (1), p.57-66

2008

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Expression of complement factor H by lung cancer cells: Effects on the activation of the alternative pathway of complement

Cancer research (Chicago, Ill.), 2004-09, Vol.64 (17), p.6310-6318

2004

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Expression of Proadrenomedullin Derived Peptides in the Mammalian Pituitary: Co-Localization of Follicle Stimulating Hormone and Proadrenomedullin N-20 Terminal Peptide-Like Peptide in the Same Secretory Granules of the Gonadotropes

Journal of neuroendocrinology, 2000-07, Vol.12 (7), p.607-617

2000

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Accumulation of hypoxia-inducible factor-1α is limited by transcription- dependent depletion

Oncogene, 2005-07, Vol.24 (30), p.4829-4838

2005

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The Effects of Adrenomedullin Overexpression in Breast Tumor Cells

JNCI : Journal of the National Cancer Institute, 2002-08, Vol.94 (16), p.1226-1237

2002

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Abscessed pneumonia with abscess secondary to infected mediastinic teratoma

Medicina intensiva, 2011-10, Vol.35 (7), p.455

2011

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Effects of Acute Hypoxia and Lipopolysaccharide on Nitric Oxide Synthase-2 Expression in Acute Lung Injury

American journal of respiratory and critical care medicine, 2003-08, Vol.168 (3), p.287-296

2003

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Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

Haematologica (Roma), 2011-05, Vol.96 (5), p.687-695

2011

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Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS

American journal of physiology. Lung cellular and molecular physiology, 2005-03, Vol.288 (3), p.L536-L545

2005

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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects

In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone

The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repair

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

P848: TINOSTAMUSTINE (EDO‐S101), AN ALKYLATOR AND HISTONE DEACETYLASE INHIBITOR, ENHANCES THE EFFICACY OF DARATUMUMAB IN PRECLINICAL MODELS OF MULTIPLE MYELOMA

Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study

Preclinical Antimyeloma Activity of EDO-S101

Filanesib (ARRY-520) Demonstrates Potent and Rapid Activity in Preclinical Models of MM, Dependent on Bcl-2 Family Expression, and Synergistic with Dexamethasone and IMiDs

The novel pan-PIM kinase inhibitor, LGH447, shows dual antitumoral and bone antiresorptive effect in multiple myeloma and synergizes with standard-of-care treatments

In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

Alternative splicing of the proadrenomedullin gene results in differential expression of gene products

La autoridad política y el poder de las letras en el Siglo de Oro

CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

The Hybrid Molecule, Edo-S101, Impairs Double Strand Breaks Repair in Multiple Myeloma and Synergizes with Bortezomib and Dexamethasone

The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype

Expression of complement factor H by lung cancer cells: Effects on the activation of the alternative pathway of complement

Expression of Proadrenomedullin Derived Peptides in the Mammalian Pituitary: Co-Localization of Follicle Stimulating Hormone and Proadrenomedullin N-20 Terminal Peptide-Like Peptide in the Same Secretory Granules of the Gonadotropes

Accumulation of hypoxia-inducible factor-1α is limited by transcription- dependent depletion

The Effects of Adrenomedullin Overexpression in Breast Tumor Cells

Abscessed pneumonia with abscess secondary to infected mediastinic teratoma

Effects of Acute Hypoxia and Lipopolysaccharide on Nitric Oxide Synthase-2 Expression in Acute Lung Injury

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS

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