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Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Neurobiology of disease, 2010-01, Vol.37 (1), p.48-57

Gabathuler, Reinhard

2010

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Blood-brain barrier transport of drugs for the treatment of brain diseases

CNS & neurological disorders drug targets, 2009-07, Vol.8 (3), p.195-204

Gabathuler, Reinhard

2009

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Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

Journal of neurochemistry, 2008-08, Vol.106 (4), p.1534-1544

2008

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Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier

Therapeutic delivery, 2010-10, Vol.1 (4), p.571-586

Gabathuler, Reinhard

2010

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Identification and design of peptides as a new drug delivery system for the brain

The Journal of pharmacology and experimental therapeutics, 2008-03, Vol.324 (3), p.1064-1072

2008

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A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

Journal of cerebral blood flow and metabolism, 2019-10, Vol.39 (10), p.2074-2088

2019

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Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells

Frontiers in neuroscience, 2021-06, Vol.15, p.596976-596976

2021

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A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier

PloS one, 2008-06, Vol.3 (6), p.e2469-e2469

2008

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Transport characteristics of a novel peptide platform for CNS therapeutics

Journal of cellular and molecular medicine, 2010-12, Vol.14 (12), p.2827-2839

2010

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A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Frontiers in molecular biosciences, 2021-03, Vol.8, p.611367-611367

2021

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High transcytosis of melanotransferrin (P97) across the blood–brain barrier

Journal of neurochemistry, 2002-11, Vol.83 (4), p.924-933

2002

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Corrigendum: A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Frontiers in molecular biosciences, 2021-05, Vol.8, p.687587-687587

2021

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Challenges and opportunities in neurometabolic disease treatment with enzyme delivery

Expert opinion on drug delivery, 2024-06, Vol.21 (6), p.1-828

2024

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Abstract 2905: The activity of a new class of biologics: trastuzumab conjugates designed to treat brain metastases of HER2+ breast cancers

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2905-2905

2014

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Développement de nouveaux vecteurs protéiniques pour le transport physiologique d’agents thérapeutiques vers le système nerveux central

Biologie aujourd'hui, 2012, Vol.206 (3), p.191-203

Gabathuler, Reinhard

2012

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Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study

Pharmaceutical research, 2016-12, Vol.33 (12), p.2930-2942

2016

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New protein vectors for physiological transfer of therapeutic agents to the central nervous system

Biologie aujourd'hui, 2012, Vol.206 (3), p.191

Gabathuler, Reinhard

2012

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Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease

Biochemical journal, 2003-09, Vol.374 (Pt 2), p.463-471

2003

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The Adenovirus E3-6.7K Protein Adopts Diverse Membrane Topologies following Posttranslational Translocation

Journal of Virology, 2004-01, Vol.78 (1), p.454-463

2004

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SCDT-45. ANTIBODY-BASED PET IMAGING OF BRAIN CANCER CELLS INFILTRATION

Neuro-oncology (Charlottesville, Va.), 2017-11, Vol.19 (suppl_6), p.vi274-vi274

2017

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Synthesis of Camptothecin Melantotransferrin (p97) Conjugate Through a Carbamate Bond

Synthetic communications, 2004, Vol.34 (13), p.2415-2424

2004

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Abstract 5017: The discovery of novel therapeutics that restore antigen processing pathways in immune-edited metastatic cancers

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5017-5017

2015

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Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localized in Neural Cells

Frontiers in neuroscience, 2021-06

2021

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Abstract 2653: Anti-cancer antibody trastuzumab-melanotransferrin conjugate (BT2111) for the treatment of metastatic HER2+ breast cancer tumors in the brain: An in vivo study

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2653-2653

2014

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Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium

Brain research, 1996-03, Vol.712 (1), p.117-121

1996

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Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Blood-brain barrier transport of drugs for the treatment of brain diseases

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

Development of new peptide vectors for the transport of therapeutic across the blood-brain barrier

Identification and design of peptides as a new drug delivery system for the brain

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells

A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier

Transport characteristics of a novel peptide platform for CNS therapeutics

A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

Corrigendum: A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Challenges and opportunities in neurometabolic disease treatment with enzyme delivery

Abstract 2905: The activity of a new class of biologics: trastuzumab conjugates designed to treat brain metastases of HER2+ breast cancers

Développement de nouveaux vecteurs protéiniques pour le transport physiologique d’agents thérapeutiques vers le système nerveux central

Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study

New protein vectors for physiological transfer of therapeutic agents to the central nervous system

Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease

The Adenovirus E3-6.7K Protein Adopts Diverse Membrane Topologies following Posttranslational Translocation

SCDT-45. ANTIBODY-BASED PET IMAGING OF BRAIN CANCER CELLS INFILTRATION

Synthesis of Camptothecin Melantotransferrin (p97) Conjugate Through a Carbamate Bond

Abstract 5017: The discovery of novel therapeutics that restore antigen processing pathways in immune-edited metastatic cancers

Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localized in Neural Cells

Abstract 2653: Anti-cancer antibody trastuzumab-melanotransferrin conjugate (BT2111) for the treatment of metastatic HER2+ breast cancer tumors in the brain: An in vivo study

Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium

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