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Calibration of ionic and cellular cardiac electrophysiology models

Wiley interdisciplinary reviews. Mechanisms of disease, 2020-07, Vol.12 (4), p.e1482-n/a

2020

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Emerging therapeutic targets in the short QT syndrome

Expert opinion on therapeutic targets, 2018-05, Vol.22 (5), p.439-451

2018

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Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

PLoS computational biology, 2017-06, Vol.13 (6), p.e1005593-e1005593

2017

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Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models

Biophysical journal, 2019-12, Vol.117 (12), p.2396-2408

2019

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Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1 -Linked Short QT Syndrome: Insights From Computational Modelling

Frontiers in physiology, 2018-10, Vol.9, p.1402-1402

2018

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In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Scientific reports, 2017-08, Vol.7 (1), p.8469-14, Article 8469

2017

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Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin

Frontiers in physiology, 2017-11, Vol.8, p.946-946

2017

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Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

Frontiers in physiology, 2017-10, Vol.8, p.759-759

2017

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In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Frontiers in physiology, 2019-01, Vol.9, p.1888-1888

2019

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A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

Frontiers in physiology, 2022-04, Vol.13, p.879035

2022

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Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An in silico Study

Frontiers in physiology, 2019-04, Vol.10, p.308-308

2019

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Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

Frontiers in physiology, 2020-11, Vol.11, p.547577-547577

2020

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The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

British journal of pharmacology, 2024-04, Vol.181 (7), p.987-1004

2024

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Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

Royal Society open science, 2021-04, Vol.8 (4), p.210235-210235, Article 210235

2021

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To the Editor–Altered in vivo systolic function in the short QT syndrome anticipated in silico

Heart rhythm, 2015-09, Vol.12 (9), p.e115-e115

2015

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A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

Wellcome open research, 2020-01, Vol.5, p.152-152

2020

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Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2020-06, Vol.378 (2173), p.20190348-20190348

2020

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Multi-scale approaches for the simulation of cardiac electrophysiology: I – Sub-cellular and stochastic calcium dynamics from cell to organ

Methods (San Diego, Calif.), 2021-01, Vol.185, p.49-59

2021

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Considering discrepancy when calibrating a mechanistic electrophysiology model

Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences, 2020-06, Vol.378 (2173), p.20190349-20190349

2020

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Multi-scale approaches for the simulation of cardiac electrophysiology: II – Tissue-level structure and function

Methods (San Diego, Calif.), 2021-01, Vol.185, p.60-81

2021

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Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

The Journal of general physiology, 2021-10, Vol.153 (10)

2021

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Ion channel model reduction using manifold boundaries

Journal of the Royal Society interface, 2022-08, Vol.19 (193), p.20220193

2022

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Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models

Journal of theoretical biology, 2023-02, Vol.558, p.111337, Article 111337

2023

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Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

Bulletin of mathematical biology, 2024-01, Vol.86 (1), p.2-2, Article 2

2024

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Learning from studying very rare cardiac conditions: the example of short QT syndrome

Journal of Congenital Cardiology, 2019-04, Vol.3 (1), p.1, Article 3

2019

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Calibration of ionic and cellular cardiac electrophysiology models

Emerging therapeutic targets in the short QT syndrome

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1 -Linked Short QT Syndrome: Insights From Computational Modelling

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models

Effects of Heart Rate and Ventricular Wall Thickness on Non-invasive Mapping: An in silico Study

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study

The impact of uncertainty in hERG binding mechanism on in silico predictions of drug‐induced proarrhythmic risk

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

To the Editor–Altered in vivo systolic function in the short QT syndrome anticipated in silico

A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer

Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments

Multi-scale approaches for the simulation of cardiac electrophysiology: I – Sub-cellular and stochastic calcium dynamics from cell to organ

Considering discrepancy when calibrating a mechanistic electrophysiology model

Multi-scale approaches for the simulation of cardiac electrophysiology: II – Tissue-level structure and function

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

Ion channel model reduction using manifold boundaries

Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models

Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics

Learning from studying very rare cardiac conditions: the example of short QT syndrome

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