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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

The New England journal of medicine, 2017-07, Vol.377 (3), p.222-232

2017

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Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM

Nature (London), 2018-08, Vol.560 (7717), p.263-267

2018

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Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes

Diabetes care, 2016-08, Vol.39 (8), p.1408-1415

2016

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Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

Circulation research, 2013-05, Vol.112 (11), p.1479-1490

2013

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Nucleic acids research, 2019-07, Vol.47 (12), p.6029-6044

2019

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MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

Cell metabolism, 2015-02, Vol.21 (2), p.298-311

2015

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ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

The Journal of clinical investigation, 2016-08, Vol.126 (8), p.2855-2866

2016

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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Nucleic acids research, 2019-07, Vol.47 (12), p.6045

2019

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Stepwise maturation of the peptidyl transferase region of human mitoribosomes

Nature communications, 2021-06, Vol.12 (1), p.3671-3671, Article 3671

2021

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Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Journal of lipid research, 2021-01, Vol.62, p.100101-100101, Article 100101

2021

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Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate

Journal of lipid research, 2017-11, Vol.58 (11), p.2127-2138

2017

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MMAB promotes negative feedback control of cholesterol homeostasis

Nature communications, 2021-11, Vol.12 (1), p.6448-6448, Article 6448

2021

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The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

Cell reports (Cambridge), 2013-10, Vol.5 (2), p.508-520

2013

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Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

EMBO molecular medicine, 2023-06, Vol.15 (6), p.e17463-n/a

2023

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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

Cell reports (Cambridge), 2016-07, Vol.16 (4), p.939-949

2016

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Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

PloS one, 2017-08, Vol.12 (8), p.e0182566

2017

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Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance

Journal of lipid research, 2017-01, Vol.58 (1), p.81-91

2017

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The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis

Journal of lipid research, 2017-02, Vol.58 (2), p.420-432

2017

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Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

PLoS genetics, 2018-10, Vol.14 (10), p.e1007732-e1007732

2018

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Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion

PloS one, 2014-06, Vol.9 (6), p.e98953-e98953

2014

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Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models

Circulation (New York, N.Y.), 2023-01, Vol.147 (3), p.242-253

2023

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Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

Journal of cardiovascular translational research, 2013-12, Vol.6 (6), p.969-980

2013

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Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Journal of lipid research, 2013-03, Vol.54 (3), p.602-614

2013

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Interorganelle phospholipid communication, a house not so divided

Trends in endocrinology and metabolism, 2024-07

2024

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Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction

Neurology. Genetics, 2018-10, Vol.4 (5), p.e276-e276

2018

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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

Stepwise maturation of the peptidyl transferase region of human mitoribosomes

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate

MMAB promotes negative feedback control of cholesterol homeostasis

The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation

Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion

Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models

Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein

Interorganelle phospholipid communication, a house not so divided

Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction

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