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Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy-Resistant L858R/T790M/C797S Mutant

Angewandte Chemie (International ed.), 2016-08, Vol.55 (36), p.10890-10894

International ed. in English, 2016

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Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors

Drug resistance updates, 2015-05, Vol.20, p.12-28

2015

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Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4293-4305

2020

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Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Journal of medicinal chemistry, 2017-06, Vol.60 (11), p.4636-4656

2017

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Targeting the Gatekeeper MET146 of C‑Jun N‑Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Journal of the American Chemical Society, 2015-11, Vol.137 (46), p.14640-14652

2015

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Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.13365-13384

2022

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Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1370-1383

2022

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Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.443-456

2015

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Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5613-5637

2017

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Simultaneous quantification of microplastic particles by non-deuterated (NoD) 1 H-qNMR from samples comprising different polymer types

Analyst (London), 2023-02, Vol.148 (5), p.1151-1161

2023

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Simultaneous quantification of microplastic particles by non-deuterated (NoD) H-qNMR from samples comprising different polymer types

Analyst (London), 2023-02, Vol.148 (5), p.1151-1161

2023

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Simultaneous quantification of microplastic particles by non-deuterated (NoD) 1H-qNMR from samples comprising different polymer types

Analyst (London), 2023-02, Vol.148 (5), p.1151-1161

2023

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Lungenkrebs: EGFR-Inhibitoren mit hoher Wirksamkeit gegen die therapieresistente L858R/T790M/C797S-Mutante

Angewandte Chemie, 2016-08, Vol.128 (36), p.11050-11054

2016

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Ferroelectric compute-in-memory annealer for combinatorial optimization problems

Nature communications, 2024-03, Vol.15 (1), p.2419-2419, Article 2419

2024

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Correction to Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2567-2567

2015

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Synthesis and structure‑activity‑relationship of 3,4‑Diaryl‑1H‑pyrrolo[2,3‑b]pyridines as irreversible Inhibitors of mutant EGFR‑L858R/T790M

European journal of pharmaceutical sciences, 2019-02, Vol.128, p.91-96

2019

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Feasibility of using quantitative .sup.1H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Analytical and bioanalytical chemistry, 2023-06, Vol.415 (15), p.3033

2023

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Feasibility of using quantitative 1H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Analytical and bioanalytical chemistry, 2023-06, Vol.415 (15), p.3033-3040

2023

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Feasibility of using quantitative 1 H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Analytical and bioanalytical chemistry, 2023-06, Vol.415 (15), p.3033

2023

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Design of a “two-in-one” mutant-selective EGFR inhibitor that spans the orthosteric and allosteric sites

Journal of medicinal chemistry, 2021-10, Vol.65 (2), p.1370-1383

2021

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Lungenkrebs: EGFR‐Inhibitoren mit hoher Wirksamkeit gegen die therapieresistente L858R/T790M/C797S‐Mutante

Angewandte Chemie, 2016-08, Vol.128 (36), p.11050-11054

2016

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Spatial stochastic population models for the analysis of city-scale systems

Günther, Marcel Christoph

2014

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Computer Vision -- ECCV 2012. Workshops and Demonstrations: Florence, Italy, October 7-13, 2012, Proceedings, Part III

2012nd edition, 2012

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Cost-effectiveness of novel drugs for the prevention of cardiovascular disease

Atherosclerosis, 2024-08, Vol.395

2024

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Eine Halbzeitbilanz – so bewerten Ökonominnen und Ökonomen die Wirtschaftspolitik der Ampel-Koalition

Ifo schnelldienst, 2023-10, Vol.76 (10), p.63-66

2023

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Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy-Resistant L858R/T790M/C797S Mutant

Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping

Targeting the Gatekeeper MET146 of C‑Jun N‑Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond

Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation

Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site

Simultaneous quantification of microplastic particles by non-deuterated (NoD) 1 H-qNMR from samples comprising different polymer types

Simultaneous quantification of microplastic particles by non-deuterated (NoD) H-qNMR from samples comprising different polymer types

Simultaneous quantification of microplastic particles by non-deuterated (NoD) 1H-qNMR from samples comprising different polymer types

Lungenkrebs: EGFR-Inhibitoren mit hoher Wirksamkeit gegen die therapieresistente L858R/T790M/C797S-Mutante

Ferroelectric compute-in-memory annealer for combinatorial optimization problems

Correction to Tetra-Substituted Pyridinylimidazoles As Dual Inhibitors of p38α Mitogen-Activated Protein Kinase and c‑Jun N‑Terminal Kinase 3 for Potential Treatment of Neurodegenerative Diseases

Synthesis and structure‑activity‑relationship of 3,4‑Diaryl‑1H‑pyrrolo[2,3‑b]pyridines as irreversible Inhibitors of mutant EGFR‑L858R/T790M

Feasibility of using quantitative .sup.1H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Feasibility of using quantitative 1H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Feasibility of using quantitative 1 H-NMR spectroscopy and ultra-microbalances for investigation of a PET microplastic reference material

Design of a “two-in-one” mutant-selective EGFR inhibitor that spans the orthosteric and allosteric sites

Lungenkrebs: EGFR‐Inhibitoren mit hoher Wirksamkeit gegen die therapieresistente L858R/T790M/C797S‐Mutante

Spatial stochastic population models for the analysis of city-scale systems

Computer Vision -- ECCV 2012. Workshops and Demonstrations: Florence, Italy, October 7-13, 2012, Proceedings, Part III

Cost-effectiveness of novel drugs for the prevention of cardiovascular disease

Eine Halbzeitbilanz – so bewerten Ökonominnen und Ökonomen die Wirtschaftspolitik der Ampel-Koalition

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