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Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 2017-09, Vol.60 (18), p.7725-7744

2017

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Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Archives of toxicology, 2013-02, Vol.87 (2), p.337-345

2013

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The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Chemico-biological interactions, 2022-01, Vol.351, p.109728-109728, Article 109728

2022

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In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

Archives of toxicology, 2017-03, Vol.91 (3), p.1335-1352

2017

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Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS

Archives of toxicology, 2023-12, Vol.97 (12), p.3179-3196

2023

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Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells

The Journal of biological chemistry, 2016-02, Vol.291 (8), p.3837-3847

2016

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Arsenic Targets Local ROS and Calcium Homeostasis at the Mitochondria-ER Interface

Biophysical journal, 2018-02, Vol.114 (3), p.659a-659a

2018

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Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Chemical science (Cambridge), 2019-12, Vol.1 (46), p.1789-181

2019

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Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells

Chemico-biological interactions, 2019-01, Vol.298, p.104-111

2019

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Bile canalicular dynamics in hepatocyte sandwich cultures

Archives of toxicology, 2015-10, Vol.89 (10), p.1861-1870

2015

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The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

Archives of toxicology, 2014-06, Vol.88 (6), p.1267-1280

2014

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Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S† †Electronic supplementary information (ESI) available. CCDC 1876852. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc03445e

Chemical science (Cambridge), 2019-10, Vol.10 (46), p.10789-10801

2019

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Proteomic alterations in primary rat hepatocytes induced by methapyrilene

Toxicology letters, 2012-06, Vol.211, p.S197-S198

2012

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Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.1981, p.25

2019

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Solved in vivo/in vitro discrepancy in methapyrilene induced gene alterations in rat liver and in collagen sandwich cultured primary rat hepatocytes

Toxicology letters, 2009-09, Vol.189, p.S77-S77

2009

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Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

Journal of neurology, neurosurgery and psychiatry, 2014-12, Vol.85 (12), p.1386-1395

2014

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Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

Science advances, 2020-06, Vol.6 (23), p.eaaz6105

2020

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Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

The Journal of clinical investigation, 2015-01, Vol.125 (1), p.413-424

2015

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Legionnaires' disease in Europe, 2011 to 2015

Euro surveillance : bulletin européen sur les maladies transmissibles, 2017-07, Vol.22 (27), p.1

Beaut, J

2017

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Spray Versus Forced Coagulation in Large Loop Excision of the Transformation Zone: A Randomized Trial

Journal of lower genital tract disease, 2016-04, Vol.20 (2), p.169-173

2016

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Legionnaires disease in Europe, 2009-2010

Euro surveillance : bulletin européen sur les maladies transmissibles, 2013-03, Vol.18 (10), p.20417-20417

2013

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A randomized, double-blind, placebo (PBO)-controlled, phase 3b study of the efficacy and safety of continuing enzalutamide (ENZA) in chemotherapy-naïve, metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with docetaxel (DOC) plus prednisolone (PDN) who have progressed on ENZA: PRESIDE

Journal of clinical oncology, 2022-02, Vol.40 (6_suppl), p.15-15

2022

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Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study

The lancet oncology, 2022-11, Vol.23 (11), p.1398-1408

2022

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Identification of the platelet ADP receptor targeted by antithrombotic drugs

Nature (London), 2001-01, Vol.409 (6817), p.202-207

2001

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Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS -Mutant Pancreatic and Colorectal Cancer

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS

Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells

Arsenic Targets Local ROS and Calcium Homeostasis at the Mitochondria-ER Interface

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells

Bile canalicular dynamics in hepatocyte sandwich cultures

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S† †Electronic supplementary information (ESI) available. CCDC 1876852. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc03445e

Proteomic alterations in primary rat hepatocytes induced by methapyrilene

Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis

Solved in vivo/in vitro discrepancy in methapyrilene induced gene alterations in rat liver and in collagen sandwich cultured primary rat hepatocytes

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

Legionnaires' disease in Europe, 2011 to 2015

Spray Versus Forced Coagulation in Large Loop Excision of the Transformation Zone: A Randomized Trial

Legionnaires disease in Europe, 2009-2010

Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study

Identification of the platelet ADP receptor targeted by antithrombotic drugs

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