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Impact of antithrombin deficiency on efficacy of edoxaban and antithrombin-dependent anticoagulants, fondaparinux, enoxaparin, and heparin

Thrombosis research, 2013-06, Vol.131 (6), p.540-546

2013

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Paradoxical enhancement of the intrinsic pathway-induced thrombin generation in human plasma by melagatran, a direct thrombin inhibitor, but not edoxaban, a direct factor Xa inhibitor, or heparin

Thrombosis research, 2015-09, Vol.136 (3), p.658-662

2015

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A Direct Oral Anticoagulant Edoxaban Enhanced Fibrinolysis Via Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor Activation and Enhancement of Plasmin Generation in Human Plasma

Blood, 2018-11, Vol.132 (Supplement 1), p.3786-3786

2018

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A direct thrombin inhibitor suppresses protein C activation and factor Va degradation in human plasma: Possible mechanisms of paradoxical enhancement of thrombin generation

Thrombosis research, 2016-05, Vol.141, p.77-83

2016

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Different antithrombotic properties of factor Xa inhibitor and thrombin inhibitor in rat thrombosis models

European journal of pharmacology, 2005-05, Vol.514 (1), p.35-42

2005

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Tranexamic Acid Failed to Reverse the Anticoagulant Effect and Bleeding by an Oral Direct Factor Xa Inhibitor Edoxaban

Pharmacology, 2018-01, Vol.101 (1-2), p.92-95

2018

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Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system

Thrombosis and haemostasis, 2011-12, Vol.106 (6), p.1076-1083

2011

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The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats

Thrombosis research, 2013-01, Vol.131 (1), p.59-63

2013

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In Vitro Characteristics, Anticoagulant Effects and In Vivo Antithrombotic Efficacy of a Novel, Potent and Orally Active Direct Factor Xa Inhibitor, DU-176b

Blood, 2004-11, Vol.104 (11), p.1862-1862

2004

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Melagatran, a direct thrombin inhibitor, but not edoxaban, a direct factor Xa inhibitor, nor heparin aggravates tissue factor-induced hypercoagulation in rats

European journal of pharmacology, 2012-07, Vol.686 (1-3), p.74-80

2012

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Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4683-4688

2007

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Antithrombin-Independent Thrombin Inhibitors, but Not Factor Xa Inhibitors, Enhance Thrombin Generation in Human Plasma Via Inhibition of Thrombin-Thrombomodulin-Protein C System

Blood, 2006-11, Vol.108 (11), p.914-914

2006

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Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives

Bioorganic & medicinal chemistry letters, 1996-01, Vol.6 (1), p.65-70

1996

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A Thrombin Inhibitor, but Not a Factor Xa Inhibitor, DU-176b, Aggravates Tissue Factor-Induced Hypercoagulation in Rats

Blood, 2005-11, Vol.106 (11), p.1878-1878

2005

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Antithrombotic and Hemorrhagic Effects of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor: A Wider Safety Margin Compared to Heparins and Warfarin

Blood, 2004-11, Vol.104 (11), p.1851-1851

2004

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P1M-02 DU-176b, an oral and direct factor Xa inhibitor: In vitro pharmacological profile, pharmacodynamics, and antithrombotic effects

Journal of Pharmacological Sciences, 2006, Vol.100 (suppl.2), p.168-168

2006

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Asp278 of Human β-Adrenergic Receptor Kinase 1 Is Essential for Phosphorylation Activity

Biochemical and biophysical research communications, 1997-10, Vol.239 (2), p.548-551

1997

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Carvedilol improved survival rate without affecting blood pressure in Dahl salt-sensitive rats

Japanese Journal of Pharmacology, 1998, Vol.76 (suppl.1), p.80-80

1998

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The stimulation mechanism of 2-deoxyglucose (2-DG) uptake by vasoactive intestinal polypeptide (VIP) in rat adipocytes

Japanese Journal of Pharmacology, 1990, Vol.52 (suppl-1.1), p.118-118

1990

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Role of bradykinin-no pathway in prevention of cardiac hypertrophy by ace inhibitor

Journal of cardiac failure, 1998-09, Vol.4 (3), p.68-68

1998

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Carvedilol improved survival rate in dahl salt-sensitive rats as a model for heart failure

Journal of cardiac failure, 1998-09, Vol.4 (3), p.95-95

1998

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Insulin-like action of 2-deoxyglucose (2-DG) uptake by vasoactive intestinal polypeptide (VIP) in rat adipocytes

Japanese Journal of Pharmacology, 1989, Vol.49 (suppl), p.159-159

1989

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Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 1996-07, Vol.6 (13), p.1487-1490

1996

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Activation of glucose transport by activatory receptor agonists of adenylate cyclase in rat adipocytes

Comparative biochemistry and physiology. A, Comparative physiology, 1990, Vol.97 (1), p.81-86

1990

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Involvement of bradykinin·NO pathway in anti-hypertrophic effects of Perindopril in the rat aortic banding model

Japanese journal of pharmacology, 1997, Vol.73, p.47-47

1997

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Impact of antithrombin deficiency on efficacy of edoxaban and antithrombin-dependent anticoagulants, fondaparinux, enoxaparin, and heparin

Paradoxical enhancement of the intrinsic pathway-induced thrombin generation in human plasma by melagatran, a direct thrombin inhibitor, but not edoxaban, a direct factor Xa inhibitor, or heparin

A Direct Oral Anticoagulant Edoxaban Enhanced Fibrinolysis Via Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor Activation and Enhancement of Plasmin Generation in Human Plasma

A direct thrombin inhibitor suppresses protein C activation and factor Va degradation in human plasma: Possible mechanisms of paradoxical enhancement of thrombin generation

Different antithrombotic properties of factor Xa inhibitor and thrombin inhibitor in rat thrombosis models

Tranexamic Acid Failed to Reverse the Anticoagulant Effect and Bleeding by an Oral Direct Factor Xa Inhibitor Edoxaban

Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system

The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats

In Vitro Characteristics, Anticoagulant Effects and In Vivo Antithrombotic Efficacy of a Novel, Potent and Orally Active Direct Factor Xa Inhibitor, DU-176b

Melagatran, a direct thrombin inhibitor, but not edoxaban, a direct factor Xa inhibitor, nor heparin aggravates tissue factor-induced hypercoagulation in rats

Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors

Antithrombin-Independent Thrombin Inhibitors, but Not Factor Xa Inhibitors, Enhance Thrombin Generation in Human Plasma Via Inhibition of Thrombin-Thrombomodulin-Protein C System

Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives

A Thrombin Inhibitor, but Not a Factor Xa Inhibitor, DU-176b, Aggravates Tissue Factor-Induced Hypercoagulation in Rats

Antithrombotic and Hemorrhagic Effects of DU-176b, a Novel, Potent and Orally Active Direct Factor Xa Inhibitor: A Wider Safety Margin Compared to Heparins and Warfarin

P1M-02 DU-176b, an oral and direct factor Xa inhibitor: In vitro pharmacological profile, pharmacodynamics, and antithrombotic effects

Asp278 of Human β-Adrenergic Receptor Kinase 1 Is Essential for Phosphorylation Activity

Carvedilol improved survival rate without affecting blood pressure in Dahl salt-sensitive rats

The stimulation mechanism of 2-deoxyglucose (2-DG) uptake by vasoactive intestinal polypeptide (VIP) in rat adipocytes

Role of bradykinin-no pathway in prevention of cardiac hypertrophy by ace inhibitor

Carvedilol improved survival rate in dahl salt-sensitive rats as a model for heart failure

Insulin-like action of 2-deoxyglucose (2-DG) uptake by vasoactive intestinal polypeptide (VIP) in rat adipocytes

Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors

Activation of glucose transport by activatory receptor agonists of adenylate cyclase in rat adipocytes

Involvement of bradykinin·NO pathway in anti-hypertrophic effects of Perindopril in the rat aortic banding model

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