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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

PLoS biology, 2021-06, Vol.19 (6), p.e3001295

2021

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Nature (London), 2017-06, Vol.546 (7656), p.118-123

2017

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Activation of the GLP-1 receptor by a non-peptidic agonist

Nature (London), 2020-01, Vol.577 (7790), p.432-436

2020

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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Nature (London), 2018-03, Vol.555 (7694), p.121-125

2018

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Structure and dynamics of the active Gs-coupled human secretin receptor

Nature communications, 2020-08, Vol.11 (1), p.1-17, Article 4137

2020

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Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

PLoS biology, 2024-07, Vol.22 (7), p.e3002673

2024

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Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

ACS pharmacology & translational science, 2020-04, Vol.3 (2), p.263-284

2020

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Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

BMC cancer, 2019-02, Vol.19 (1), p.157-157, Article 157

2019

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Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination

ACS pharmacology & translational science, 2018-09, Vol.1 (1), p.12-20

2018

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Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers

Neurogastroenterology and motility, 2021-05, Vol.33 (5), p.e14051-n/a

2021

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Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

PloS one, 2014-03, Vol.9 (3), p.e92042-e92042

2014

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Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

British journal of pharmacology, 2015-01, Vol.172 (1), p.185-200

2015

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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (45), p.18607-18612

2012

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Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

Endocrinology (Philadelphia), 2008-11, Vol.149 (11), p.5423-5431

2008

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Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Cancer Immunology, Immunotherapy, 2017-09, Vol.66 (9), p.1217-1228

2017

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Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Nature (London), 2018-06, Vol.558 (7711), p.559-563

2018

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TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

Frontiers in molecular neuroscience, 2019-08, Vol.12, p.205

2019

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The Molecular Control of Calcitonin Receptor Signaling

ACS pharmacology & translational science, 2019-02, Vol.2 (1), p.31-51

2019

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Coding GPCR-G protein specificity

Cell research, 2017-10, Vol.27 (10), p.1193-1194

2017

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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Frontiers in endocrinology (Lausanne), 2021-12, Vol.12, p.789957

2021

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Consequences of splice variation on Secretin family G protein‐coupled receptor function

British journal of pharmacology, 2012-05, Vol.166 (1), p.98-109

2012

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Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

Therapeutic Advances in Medical Oncology, 2020, Vol.12, p.1758835920978110

2020

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The nature of efficacy at G protein-coupled receptors

Biochemical pharmacology, 2019-12, Vol.170, p.113647-113647, Article 113647

2019

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The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Pharmacology & therapeutics (Oxford), 2009-12, Vol.124 (3), p.336-353

2009

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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

Molecular cell, 2020-11, Vol.80 (3), p.485-500.e7

2020

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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Activation of the GLP-1 receptor by a non-peptidic agonist

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Structure and dynamics of the active Gs-coupled human secretin receptor

Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR‑G Protein Complexes for Structure Determination

Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

The Molecular Control of Calcitonin Receptor Signaling

Coding GPCR-G protein specificity

Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

Consequences of splice variation on Secretin family G protein‐coupled receptor function

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

The nature of efficacy at G protein-coupled receptors

The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

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