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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Nature communications, 2019-01, Vol.10 (1), p.137-137, Article 137

2019

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2017-07, Vol.8 (1), p.103-14, Article 103

2017

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Ena/VASP is required for endothelial barrier function in vivo

The Journal of cell biology, 2007-11, Vol.179 (4), p.761-775

2007

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2019-06, Vol.10 (1), p.2527-2527, Article 2527

2019

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DEF-1/ASAP1 Is a GTPase-activating Protein (GAP) for ARF1 That Enhances Cell Motility through a GAP-dependent Mechanism

The Journal of biological chemistry, 2002-03, Vol.277 (10), p.7962-7969

2002

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Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come

Cancer research (Chicago, Ill.), 2019-04, Vol.79 (8), p.1740-1745

2019

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

The Journal of biological chemistry, 2022-11, Vol.298 (11), p.102539, Article 102539

2022

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Modulation of immunosurveillance by tumor-intrinsic genomic alterations

Immunotherapy, 2017-12, Vol.9 (16), p.1305-1307

2017

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Filopodia are required for cortical neurite initiation

Nature cell biology, 2007-12, Vol.9 (12), p.1347-1359

2007

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.890-902

2022

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Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.PS12-23-PS12-23

2021

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Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.281-281

2019

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.DDT01-04-DDT01-04

2017

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Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2941-2941

2015

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Abstract C8: Targeting MCL1-dependent cancers with SF3B splicing modulators

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C8-C8

2015

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Cancer discovery, 2018-09, Vol.8 (9), p.1176-1193

2018

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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

Journal of Virology, 1993-07, Vol.67 (7), p.3978-3988

1993

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Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

Journal of Virology, 1990-12, Vol.64 (12), p.5701-5707

1990

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Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

Journal of Virology, 1991-04, Vol.65 (4), p.2119-2123

1991

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Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody

Journal of Virology, 1991-11, Vol.65 (11), p.6188-6193

1991

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Ena/VASP is required for endothelial barrier function in vivo

The Journal of experimental medicine, 2007-11, Vol.204 (12), p.i26-i26

2007

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Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein

Journal of Virology, 1992-09, Vol.66 (9), p.5635-5641

1992

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Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody

Journal of Virology, 1993-06, Vol.67 (6), p.3674-3679

1993

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Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

Journal of Virology, 1991-09, Vol.65 (9), p.5007-5012

1991

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Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

Journal of Virology, 1992-09, Vol.66 (9), p.5516-5524

1992

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Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Ena/VASP is required for endothelial barrier function in vivo

Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

DEF-1/ASAP1 Is a GTPase-activating Protein (GAP) for ARF1 That Enhances Cell Motility through a GAP-dependent Mechanism

Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come

Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists

Modulation of immunosurveillance by tumor-intrinsic genomic alterations

Filopodia are required for cortical neurite initiation

Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators

Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Abstract C8: Targeting MCL1-dependent cancers with SF3B splicing modulators

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody

Ena/VASP is required for endothelial barrier function in vivo

Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein

Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody

Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity

Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events

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