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Organocatalytic Enantioselective One-Pot Four-Component Ugi-Type Multicomponent Reaction for the Synthesis of Epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones

Chemistry : a European journal, 2012-10, Vol.18 (40), p.12624-12627

2012

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Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors

PLoS neglected tropical diseases, 2017-02, Vol.11 (2), p.e0005343-e0005343

2017

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Frank Lloyd-Griffiths

Veterinary record, 2018-05, Vol.182 (18), p.522-522

2018

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The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro

Purinergic signalling, 2010-09, Vol.6 (3), p.307-315

2010

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A convenient synthesis of sulfonylureas from carboxylic acids and sulfonamides via an in situ Curtius rearrangement

Tetrahedron letters, 2007-12, Vol.48 (50), p.8878-8882

2007

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NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation

Journal of cell science, 2019-04, Vol.132 (7)

2019

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Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles

Advanced synthesis & catalysis, 2014-05, Vol.356 (8), p.1719-1724

2014

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Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3123-3141

2009

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Antagonists of the P2X(7) receptor. From lead identification to drug development

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3123-3141

2009

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Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2357-2367

2014

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Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles

Advanced synthesis & catalysis, 2014-05, Vol.356 (8), p.1888-1888

2014

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The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

ChemMedChem, 2011-05, Vol.6 (5), p.769-773

2011

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A Palladium-Catalyzed Synthesis of Amidines from Aryl Halides

Angewandte Chemie (International ed.), 2000-11, Vol.39 (22), p.4156-4158

2000

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Identification of antheridiogens in Lygodium circinnatum and Lygodium flexuosum

Plant physiology (Bethesda), 1996-07, Vol.111 (3), p.741-745

1996

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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.5882-5885

2007

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Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.492-496

2011

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Palladium catalysed synthesis of cyclic amidines and imidates

Tetrahedron letters, 2004-09, Vol.45 (38), p.6995-6996

2004

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Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.531-536

2011

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Palladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides

Tetrahedron letters, 2001-08, Vol.42 (35), p.6191-6194

2001

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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7702-7706

2012

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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7707-7710

2012

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Synthesis of alpha-iminoimidates by palladium catalysed double isonitrile insertion

Organic & biomolecular chemistry, 2004-07, Vol.2 (14), p.1974-1976

2004

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Antagonists of the P2X 7 Receptor. From Lead Identification to Drug Development

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3123-3141

2009

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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors

Journal of medicinal chemistry, 2007-11, Vol.50 (24), p.5882-5885

2007

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Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline, [1,2,3]triazolo[1,5- a]quinoxaline and [1,2,3]triazolo[5,1- c]benzotriazine derivatives

Tetrahedron, 2002-04, Vol.58 (16), p.3185-3198

2002

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Organocatalytic Enantioselective One-Pot Four-Component Ugi-Type Multicomponent Reaction for the Synthesis of Epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors

Frank Lloyd-Griffiths

The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro

A convenient synthesis of sulfonylureas from carboxylic acids and sulfonamides via an in situ Curtius rearrangement

NIK-IKK complex interaction controls NF-κB-dependent inflammatory activation of endothelium in response to LTβR ligation

Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles

Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development

Antagonists of the P2X(7) receptor. From lead identification to drug development

Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate

Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

A Palladium-Catalyzed Synthesis of Amidines from Aryl Halides

Identification of antheridiogens in Lygodium circinnatum and Lygodium flexuosum

Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

Palladium catalysed synthesis of cyclic amidines and imidates

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

Palladium-catalysed synthesis of imidates, thioimidates and amidines from aryl halides

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance

Synthesis of alpha-iminoimidates by palladium catalysed double isonitrile insertion

Antagonists of the P2X 7 Receptor. From Lead Identification to Drug Development

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors

Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline, [1,2,3]triazolo[1,5- a]quinoxaline and [1,2,3]triazolo[5,1- c]benzotriazine derivatives

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