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Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment

Current opinion in pharmacology, 2016-12, Vol.31, p.97-103

2016

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ESR1 mutations in breast cancer

Cancer, 2019-11, Vol.125 (21), p.3714-3728

2019

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Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

Breast cancer research : BCR, 2012-06, Vol.14 (3), p.R95-R95, Article R95

2012

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ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling

Breast cancer research and treatment, 2016-06, Vol.157 (2), p.253-265

2016

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Estrogen Receptor Mutations in Human Disease

Endocrine reviews, 2004-12, Vol.25 (6), p.869-898

2004

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In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells

Molecular nutrition & food research, 2013-05, Vol.57 (5), p.840-853

2013

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Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells

Molecular oncology, 2013-06, Vol.7 (3), p.379-391

2013

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Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer

Clinical cancer research, 2004-11, Vol.10 (22), p.7490-7499

2004

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Phosphorylation of estrogen receptor α blocks its acetylation and regulates estrogen sensitivity

Cancer research (Chicago, Ill.), 2004-12, Vol.64 (24), p.9199-9208

2004

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The role of androgen receptor in breast cancer

Drug discovery today. Disease mechanisms, 2012-01, Vol.9 (1-2), p.e19-e27

2012

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Abstract PD6-6: Estrogen receptor (ESR1) mutations confer resistance to hormone therapy using a common mechanism

Cancer research (Chicago, Ill.), 2015-05, Vol.75 (9_Supplement), p.PD6-6-PD6-6

2015

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Metastasis-Associated Protein 2 Is a Repressor of Estrogen Receptor α Whose Overexpression Leads to Estrogen-Independent Growth of Human Breast Cancer Cells

Molecular endocrinology (Baltimore, Md.), 2006-09, Vol.20 (9), p.2020-2035

2006

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Estrogen receptor (ER) [alpha] mutations in breast cancer: hidden in plain sight

Breast cancer research and treatment, 2014-02, Vol.144 (1), p.11-19

2014

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ESR1 Mutations in Cell-Free DNA of Breast Cancer: Predictive "Tip of the Iceberg"

JAMA oncology, 2016-10, Vol.2 (10), p.1315

2016

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Association between the Estrogen Receptor α A908G Mutation and Outcomes in Invasive Breast Cancer

Clinical cancer research, 2007-06, Vol.13 (11), p.3235-3243

2007

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Evidence for diversity in transcriptional profiles of single hematopoietic stem cells

PLoS genetics, 2006-09, Vol.2 (9), p.e159-e159

2006

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hypersensitive estrogen receptor α mutation that alters dynamic protein interactions

Breast cancer research and treatment, 2010-07, Vol.122 (2), p.381-393

2010

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Aromatase Inhibitor Resistance in Breast Cancer: a Potential Role for Cytokine Signaling Network

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Negative regulation of estrogen receptor α transactivation functions by LIM domain only 4 protein

Cancer research (Chicago, Ill.), 2005-11, Vol.65 (22), p.10594-10601

2005

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Abstract P5-05-03: Clonal evolution of the HER2 L755S mutation leads to acquired HER-targeted therapy resistance that can be reversed by the irreversible HER1/2 inhibitor afatinib

Cancer research (Chicago, Ill.), 2015-05, Vol.75 (9_Supplement), p.P5-P5-05-03

2015

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Abstract S4-03: Identification of a notch-driven breast cancer stem cell gene signature for anti-notch therapy in an ER+ presurgical window model

Cancer research (Chicago, Ill.), 2015-05, Vol.75 (9_Supplement), p.S4-S4-03

2015

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Resveratrol, through NF‐Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38MAPK/CK2 signaling in human breast cancer cells

The FASEB journal, 2011-10, Vol.25 (10), p.3695-3707

2011

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Tumour and cellular distribution of activated forms of PR in breast cancers: a novel immunohistochemical analysis of a large clinical cohort

ESMO open, 2016, Vol.1 (4), p.e000072-e000072, Article e000072

2016

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Abstract 1996: Identification of four subgroups of Triple Negative Breast Cancer (TNBC) by genomic profiling

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.1996-1996

2013

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In vitro mechanism for down-regulation of ERalpha expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells

Molecular nutrition & food research, 2013-01, Vol.57 (5), p.840-853

2013

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Targeted therapy for breast cancer and molecular mechanisms of resistance to treatment

ESR1 mutations in breast cancer

Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

ESR1 mutations affect anti-proliferative responses to tamoxifen through enhanced cross-talk with IGF signaling

Estrogen Receptor Mutations in Human Disease

In vitro mechanism for downregulation of ER-α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells

Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells

Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer

Phosphorylation of estrogen receptor α blocks its acetylation and regulates estrogen sensitivity

The role of androgen receptor in breast cancer

Abstract PD6-6: Estrogen receptor (ESR1) mutations confer resistance to hormone therapy using a common mechanism

Metastasis-Associated Protein 2 Is a Repressor of Estrogen Receptor α Whose Overexpression Leads to Estrogen-Independent Growth of Human Breast Cancer Cells

Estrogen receptor (ER) [alpha] mutations in breast cancer: hidden in plain sight

ESR1 Mutations in Cell-Free DNA of Breast Cancer: Predictive "Tip of the Iceberg"

Association between the Estrogen Receptor α A908G Mutation and Outcomes in Invasive Breast Cancer

Evidence for diversity in transcriptional profiles of single hematopoietic stem cells

hypersensitive estrogen receptor α mutation that alters dynamic protein interactions

Aromatase Inhibitor Resistance in Breast Cancer: a Potential Role for Cytokine Signaling Network

Negative regulation of estrogen receptor α transactivation functions by LIM domain only 4 protein

Abstract P5-05-03: Clonal evolution of the HER2 L755S mutation leads to acquired HER-targeted therapy resistance that can be reversed by the irreversible HER1/2 inhibitor afatinib

Abstract S4-03: Identification of a notch-driven breast cancer stem cell gene signature for anti-notch therapy in an ER+ presurgical window model

Resveratrol, through NF‐Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38MAPK/CK2 signaling in human breast cancer cells

Tumour and cellular distribution of activated forms of PR in breast cancers: a novel immunohistochemical analysis of a large clinical cohort

Abstract 1996: Identification of four subgroups of Triple Negative Breast Cancer (TNBC) by genomic profiling

In vitro mechanism for down-regulation of ERalpha expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells

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