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Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis

Archives of toxicology, 2024-10

2024

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Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells

Drug metabolism and disposition, 2024-09, Vol.52 (9), p.949-956

2024

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Iminium ion metabolites are formed from nintedanib by human CYP3A4

Drug metabolism and pharmacokinetics, 2024-08, Vol.57, p.101025, Article 101025

2024

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Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

Drug metabolism and pharmacokinetics, 2024-06, Vol.56, p.101007, Article 101007

2024

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NEAT1_2 and DAZAP1, paraspeckle components, interact with PXR to negatively regulate CYP3A4 induction

Drug metabolism and disposition, 2023-10, Vol.51 (10), p.1230-1237

2023

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ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver

Biochemical pharmacology, 2023-09, Vol.215, p.115733-115733, Article 115733

2023

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In vitro evaluation of the reductase activities of human AKR1C3 allelic variants

Drug metabolism and disposition, 2023-09, Vol.51 (9), p.1188-1195

2023

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Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug

Drug metabolism and disposition, 2023-08, Vol.51 (8), p.1016-1023

2023

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Characterization of Enzymes Involved in Nintedanib Metabolism in Humans

Drug metabolism and disposition, 2023-06, Vol.51 (6), p.733-742

2023

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Activation of Inflammation by MCF-7 Cells-Derived Small Extracellular Vesicles (sEV): Comparison of Three Different Isolation Methods of sEV

Pharmaceutical research, 2023-04, Vol.40 (4), p.863-871

2023

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Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism

Archives of biochemistry and biophysics, 2023-03, Vol.736, p.109536-109536, Article 109536

2023

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Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver

Drug metabolism and disposition, 2023-01, Vol.51 (1), p.17-28

2023

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Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status

Biochemical pharmacology, 2022-11, Vol.205, p.115247-115247, Article 115247

2022

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Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.725-733

2022

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PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism

Biochemical pharmacology, 2022-05, Vol.199, p.115010-115010, Article 115010

2022

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Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency

Biochemical pharmacology, 2022-01, Vol.195, p.114842, Article 114842

2022

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Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver

Xenobiotica, 2021-12, Vol.51 (12), p.1352-1359

2021

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Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans

Life sciences (1973), 2021-11, Vol.284, p.119896, Article 119896

2021

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m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2

Biochemical pharmacology, 2021-11, Vol.193, p.114766-114766, Article 114766

2021

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m 6 A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2

Biochemical pharmacology, 2021-11, Vol.193, p.114766

2021

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Characteristics of miRNA-SNPs in healthy Japanese subjects and non-small cell lung cancer, colorectal cancer, and soft tissue sarcoma patients

Non-coding RNA research, 2021-09, Vol.6 (3), p.123-129

2021

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Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans

Drug metabolism and disposition, 2021-09, Vol.49 (9), p.718-728

2021

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The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression

Biochemical pharmacology, 2021-07, Vol.189, p.114402, Article 114402

2021

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The N 6 -methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression

Biochemical pharmacology, 2021-07, p.114402

2021

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Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC

European journal of pharmaceutical sciences, 2021-06, Vol.161, p.105807, Article 105807

2021

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Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis

Cytochrome P450 and UDP-Glucuronosyltransferase Expressions, Activities, and Induction Abilities in 3D-Cultured Human Renal Proximal Tubule Epithelial Cells

Iminium ion metabolites are formed from nintedanib by human CYP3A4

Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

NEAT1_2 and DAZAP1, paraspeckle components, interact with PXR to negatively regulate CYP3A4 induction

ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver

In vitro evaluation of the reductase activities of human AKR1C3 allelic variants

Evaluation of Drug-Drug Interactions via Inhibition of Hydrolases by Orlistat, an Anti-Obesity Drug

Characterization of Enzymes Involved in Nintedanib Metabolism in Humans

Activation of Inflammation by MCF-7 Cells-Derived Small Extracellular Vesicles (sEV): Comparison of Three Different Isolation Methods of sEV

Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism

Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver

Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status

Methionine Sulfoxide Reductase A in Human and Mouse Tissues is Responsible for Sulindac Activation, Making a Larger Contribution than the Gut Microbiota

PPARα regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism

Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency

Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver

Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans

m6A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2

m 6 A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2

Characteristics of miRNA-SNPs in healthy Japanese subjects and non-small cell lung cancer, colorectal cancer, and soft tissue sarcoma patients

Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans

The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression

The N 6 -methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression

Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC

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