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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)

Alzheimer's research & therapy, 2018-09, Vol.10 (1), p.96-96, Article 96

2018

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An automated mapping method for Nissl-stained mouse brain histologic sections

Journal of neuroscience methods, 2018-10, Vol.308, p.219-227

2018

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Science translational medicine, 2015-02, Vol.7 (273), p.273ra15

2015

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Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid

Clinical pharmacology and therapeutics, 2022-04, Vol.111 (4), p.826-834

2022

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Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

Science translational medicine, 2021-05, Vol.13 (593)

2021

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Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier

Science translational medicine, 2013-05, Vol.5 (183), p.183ra57, 1

2013

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Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology

Toxicologic pathology, 2023-08, Vol.51 (6), p.313-328

2023

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Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

Journal of medicinal chemistry, 2017-10, Vol.60 (19), p.8083-8102

2017

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Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry

Toxicologic pathology, 2022-12, Vol.50 (8), p.942-949

2022

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Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Clinical cancer research, 2010-10, Vol.16 (19), p.4769-4778

2010

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Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic pathology, 2020-01, Vol.48 (1), p.238-243

2020

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Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection

Cancer research (Chicago, Ill.), 2009-03, Vol.69 (6), p.2358-2364

2009

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

Alzheimer's research & therapy, 2019-12, Vol.11 (1), p.97-97, Article 97

2019

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The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell‐surface‐targeted biological agents in patients

British journal of pharmacology, 2012-07, Vol.166 (5), p.1600-1602

2012

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Multiscale generative model using regularized skip-connections and perceptual loss for anomaly detection in toxicologic histopathology

Journal of pathology informatics, 2022-01, Vol.13, p.100102-100102, Article 100102

2022

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Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates

British journal of pharmacology, 2017-11, Vol.174 (22), p.4173-4185

2017

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Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

CPT: pharmacometrics and systems pharmacology, 2023-01, Vol.12 (1), p.62-73

2023

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Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism

Alzheimer's & dementia, 2024-08

2024

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Analysis of cellularity in H&E-stained rat bone marrow tissue via deep learning

Journal of pathology informatics, 2023-01, Vol.14, p.100333-100333, Article 100333

2023

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An integrated approach to identify normal tissue expression of targets for antibody‐drug conjugates: case study of TENB2

British journal of pharmacology, 2013-01, Vol.168 (2), p.445-457

2013

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In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

Molecular cancer therapeutics, 2009-10, Vol.8 (10), p.2937-2946

2009

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RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

Current biology, 2003-09, Vol.13 (17), p.1469-1479

2003

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Evolutionary conservation of histone macroH2A subtypes and domains

Nucleic acids research, 1998-06, Vol.26 (12), p.2837

1998

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)

An automated mapping method for Nissl-stained mouse brain histologic sections

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier

Assessment of Color Reproducibility and Mitigation of Color Variation in Whole Slide Image Scanners for Toxicologic Pathology

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease

Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Autophagy of Sensory Neurons in the Trigeminal and Dorsal Root Ganglia of Cynomolgus Monkeys (Macaca fascicularis)

Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection

Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell‐surface‐targeted biological agents in patients

Multiscale generative model using regularized skip-connections and perceptual loss for anomaly detection in toxicologic histopathology

Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism

Analysis of cellularity in H&E-stained rat bone marrow tissue via deep learning

An integrated approach to identify normal tissue expression of targets for antibody‐drug conjugates: case study of TENB2

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

Evolutionary conservation of histone macroH2A subtypes and domains

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