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Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation

Chemical reviews, 2015-06, Vol.115 (11), p.5413-5461

2015

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Protein Arginine Methylation and Citrullination in Epigenetic Regulation

ACS chemical biology, 2016-03, Vol.11 (3), p.654-668

2016

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Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I

Circulation (New York, N.Y.), 2017-04, Vol.135 (17), p.1597-1611

2017

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Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation in the Bacterial Stress Response

Molecular & cellular proteomics, 2014-02, Vol.13 (2), p.537-550

2014

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Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2195-2208

2016

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Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

Molecular & cellular proteomics, 2014-08, Vol.13 (8), p.1953-1964

2014

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A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Nature communications, 2018-11, Vol.9 (1), p.4687-14, Article 4687

2018

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Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation

Cell chemical biology, 2016-08, Vol.23 (8), p.967-977

2016

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Defining a conformational ensemble that directs activation of PPARγ

Nature communications, 2018-05, Vol.9 (1), p.1794-16, Article 1794

2018

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Chemical and biological methods to detect post-translational modifications of arginine

Biopolymers, 2014-02, Vol.101 (2), p.133-143

2014

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Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1

ACS chemical biology, 2016-07, Vol.11 (7), p.1795-1799

2016

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Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria

Cell reports (Cambridge), 2013-06, Vol.3 (6), p.1832-1839

2013

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Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation

Blood, 2006-01, Vol.107 (1), p.118-125

2006

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Synthesis and Use of a Phosphonate Amidine to Generate an Anti-Phosphoarginine-Specific Antibody

Angewandte Chemie (International ed.), 2015-12, Vol.54 (49), p.14715-14718

International ed. in English, 2015

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Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion

Biochemistry (Easton), 2014-12, Vol.53 (50), p.7884-7892

2014

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Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.8585-8608

2024

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Chemical Tools to Study the Biology of Protein Arginine Phosphorylation

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Proceedings of the National Academy of Sciences - PNAS, 2022-11, Vol.119 (46), p.1-e2207327119

2022

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Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor

ACS chemical biology, 2017-04, Vol.12 (4), p.969-978

2017

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Lead Optimization Yields High Affinity Frizzled 7‑Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7739-7750

2019

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McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR

Science (American Association for the Advancement of Science), 2009-06, Vol.324 (5932), p.1323-1327

2009

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Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

ACS chemical biology, 2020-06, Vol.15 (6), p.1392-1400

2020

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Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

ACS chemical biology, 2015-04, Vol.10 (4), p.1043-1053

2015

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Targeting the Arginine Phosphatase YwlE with a Catalytic Redox-Based Inhibitor

ACS chemical biology, 2013-09, Vol.8 (9), p.2024-2032

2013

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Probing the Complex Binding Modes of the PPARγ Partial Agonist 2‑Chloro‑N‑(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10335-10341

2016

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Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I

Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation in the Bacterial Stress Response

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

Chasing Phosphoarginine Proteins: Development of a Selective Enrichment Method Using a Phosphatase Trap

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation

Defining a conformational ensemble that directs activation of PPARγ

Chemical and biological methods to detect post-translational modifications of arginine

Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1

Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria

Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation

Synthesis and Use of a Phosphonate Amidine to Generate an Anti-Phosphoarginine-Specific Antibody

Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion

Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability

Chemical Tools to Study the Biology of Protein Arginine Phosphorylation

Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling

Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor

Lead Optimization Yields High Affinity Frizzled 7‑Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design

Targeting the Arginine Phosphatase YwlE with a Catalytic Redox-Based Inhibitor

Probing the Complex Binding Modes of the PPARγ Partial Agonist 2‑Chloro‑N‑(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy

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