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Protein-protein interactions as targets for small molecule drug discovery

Biopolymers, 2006, Vol.84 (6), p.535-552

Fry, David C.

2006

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Small-molecule inhibitors of protein-protein interactions: how to mimic a protein partner

Current pharmaceutical design, 2012-10, Vol.18 (30), p.4679

Fry, David C

2012

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

ACS medicinal chemistry letters, 2014-09, Vol.5 (9), p.993-998

2014

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Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

ACS medicinal chemistry letters, 2013-07, Vol.4 (7), p.660-665

2013

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Targeting protein-protein interactions for drug discovery

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1278, p.93

Fry, David C

2015

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Targeting protein-protein interactions for cancer therapy

Journal of molecular medicine (Berlin, Germany), 2005-12, Vol.83 (12), p.955-963

2005

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Concepts and progress in the development of peptide mimetics

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3039-3049

1993

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Druggability assessment of protein-protein interfaces

Future medicinal chemistry, 2011-12, Vol.3 (16), p.2021-2038

2011

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A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (10), p.2671-2677

2004

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Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

Biochemistry (Easton), 1995-05, Vol.34 (21), p.6911-6918

1995

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NMR structure of a complex between MDM2 and a small molecule inhibitor

Journal of biomolecular NMR, 2004-10, Vol.30 (2), p.163-173

2004

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Development of E3‐Substrate (MDM2‐p53)–Binding Inhibitors: Structural Aspects

Methods in Enzymology, 2005, Vol.399, p.622-633

2005

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Identification of a Small Molecule Inhibitor of the IL-2/IL-2Rα Receptor Interaction Which Binds to IL-2

Journal of the American Chemical Society, 1997-08, Vol.119 (32), p.7589-7590

1997

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Drug-like inhibitors of protein-protein interactions: a structural examination of effective protein mimicry

Current protein & peptide science, 2008-06, Vol.9 (3), p.240

Fry, D C

2008

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1H, 15N, and 13C resonance assignments of human interleukin-2

Journal of biomolecular NMR, 2005-07, Vol.32 (3), p.258-258

2005

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Chemical Shift Assignments and Folding Topology of the RAS-Binding Domain of Human RAF-1 As Determined by Heteronuclear Three-Dimensional NMR Spectroscopy

Biochemistry (Easton), 1994-06, Vol.33 (25), p.7745-7752

1994

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Solution structure of an analog of vasoactive intestinal peptide as determined by two-dimensional NMR and circular dichroism spectroscopies and constrained molecular dynamics

Biochemistry (Easton), 1989-03, Vol.28 (6), p.2399-2409

1989

Volltextzugriff (PDF)

NMR characterization of interleukin‐2 in complexes with the IL‐2Rα receptor component, and with low molecular weight compounds that inhibit the IL‐2/IL‐Rα interaction

Protein science, 2003-04, Vol.12 (4), p.811-822

2003

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NMR studies of the AMP-binding site and mechanism of adenylate kinase

Biochemistry (Easton), 1987-03, Vol.26 (6), p.1645-1655

1987

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Modulators of Protein–Protein Interactions: Importance of Three-Dimensionality

Protein-Protein Interactions in Drug Discovery, 2013, Vol.56, p.55-62

2013

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ATP-Binding Site of Adenylate Kinase: Mechanistic Implications of Its Homology with ras-Encoded p21, F1-ATPase, and Other Nucleotide-Binding Proteins

Proceedings of the National Academy of Sciences - PNAS, 1986-02, Vol.83 (4), p.907-911

1986

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Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase

Biochemistry (Easton), 1987-07, Vol.26 (14), p.4466-4470

1987

Volltextzugriff (PDF)

NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase

Biochemistry (Easton), 1984-07, Vol.23 (14), p.3161-3173

1984

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Photoinactivation of Agaricus bisporus tyrosinase: modification of the binuclear copper site

Biochemistry (Easton), 1983-01, Vol.22 (21), p.4949-4953

1983

Volltextzugriff (PDF)

Distinguishing among protein kinases by substrate specificities

Biochemistry (Easton), 1987-07, Vol.26 (14), p.4471-4474

1987

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Protein-protein interactions as targets for small molecule drug discovery

Small-molecule inhibitors of protein-protein interactions: how to mimic a protein partner

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

Targeting protein-protein interactions for drug discovery

Targeting protein-protein interactions for cancer therapy

Concepts and progress in the development of peptide mimetics

Druggability assessment of protein-protein interfaces

A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

NMR structure of a complex between MDM2 and a small molecule inhibitor

Development of E3‐Substrate (MDM2‐p53)–Binding Inhibitors: Structural Aspects

Identification of a Small Molecule Inhibitor of the IL-2/IL-2Rα Receptor Interaction Which Binds to IL-2

Drug-like inhibitors of protein-protein interactions: a structural examination of effective protein mimicry

1H, 15N, and 13C resonance assignments of human interleukin-2

Chemical Shift Assignments and Folding Topology of the RAS-Binding Domain of Human RAF-1 As Determined by Heteronuclear Three-Dimensional NMR Spectroscopy

Solution structure of an analog of vasoactive intestinal peptide as determined by two-dimensional NMR and circular dichroism spectroscopies and constrained molecular dynamics

NMR characterization of interleukin‐2 in complexes with the IL‐2Rα receptor component, and with low molecular weight compounds that inhibit the IL‐2/IL‐Rα interaction

NMR studies of the AMP-binding site and mechanism of adenylate kinase

Modulators of Protein–Protein Interactions: Importance of Three-Dimensionality

ATP-Binding Site of Adenylate Kinase: Mechanistic Implications of Its Homology with ras-Encoded p21, F1-ATPase, and Other Nucleotide-Binding Proteins

Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase

NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase

Photoinactivation of Agaricus bisporus tyrosinase: modification of the binuclear copper site

Distinguishing among protein kinases by substrate specificities

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