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Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

Journal of labelled compounds & radiopharmaceuticals, 2023-09, Vol.66 (11), p.336-344

2023

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Carbon 14 and stable isotope synthesis of two potent and selective phosphodiesterase type 4 inhibitors

Journal of labelled compounds & radiopharmaceuticals, 2023-09, Vol.66 (11), p.353-361

2023

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Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Journal of organic chemistry, 2006-09, Vol.71 (19), p.7133-7145

2006

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Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

Journal of labelled compounds & radiopharmaceuticals, 2023-11, Vol.66 (13), p.414-427

2023

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One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

Journal of organic chemistry, 2013-06, Vol.78 (11), p.5800-5803

2013

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Asymmetric Oxidation of a Dihydrothienopyrimidine

Organic process research & development, 2017-03, Vol.21 (3), p.444-447

2017

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Development of a Practical Process for the Synthesis of PDE4 Inhibitors

Organic process research & development, 2016-05, Vol.20 (5), p.982-988

2016

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Development of a Safe and Economical Synthesis of Methyl 6‑Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale

Organic process research & development, 2013-06, Vol.17 (6), p.940-945

2013

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A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors

Asian journal of organic chemistry, 2014-07, Vol.3 (7), p.769-772

2014

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A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists

Tetrahedron letters, 2011-05, Vol.52 (19), p.2465-2467

2011

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Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale

Organic process research & development, 2011-09, Vol.15 (5), p.1185-1191

2011

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Efficient Multikilogram Synthesis of 5-Bromo-2-cyclopropyl-1-methyl-1H-imidazole

Organic process research & development, 2007-11, Vol.11 (6), p.1076-1078

2007

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Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

Organic process research & development, 2005-03, Vol.9 (2), p.137-140

2005

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Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

Journal of organic chemistry, 1994-10, Vol.59 (21), p.6322-6337

1994

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Intramolecular formal [3 + 2] cycloaddition of alkenes and benzylic cations. Stereoselective synthesis of 1,2,3,4,4a,9a-hexahydrofluorenes

Journal of organic chemistry, 1993-09, Vol.58 (19), p.5135-5144

1993

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Expedient synthesis of substituted imidazoles from nitriles

Tetrahedron letters, 2005-11, Vol.46 (48), p.8369-8372

2005

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ChemInform Abstract: One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

ChemInform, 2013-10, Vol.44 (41), p.no-no

2013

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Stereoselective synthesis of 1-aryl-4a-methyloctahydrophenanthrenes via cyclization reactions initiated by benzylic cations

Journal of organic chemistry, 1993-12, Vol.58 (27), p.7918-7922

1993

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Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors

Tetrahedron letters, 2003-08, Vol.44 (34), p.6509-6511

2003

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Practical Synthesis of 2-(2-Isopropylaminothiazol-4-yl)-7-methoxy-1H-quinolin-4-one: Key Intermediate for the Synthesis of Potent HCV NS3 Protease Inhibitor BILN 2061

Synthesis (Stuttgart), 2006-08, Vol.2006 (15), p.2563-2567

2006

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A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

Tetrahedron letters, 2005-01, Vol.46 (2), p.273-276

2005

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An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

Tetrahedron: asymmetry, 2001-02, Vol.12 (1), p.101-104

2001

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Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement

Tetrahedron letters, 1998-04, Vol.39 (17), p.2475-2478

1998

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Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters

Tetrahedron: asymmetry, 2003-11, Vol.14 (22), p.3495-3501

2003

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Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1 H -imidazo[1,2- a ]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

Organic process research & development, 2005-03, Vol.9 (2), p.137-140

2005

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Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

Carbon 14 and stable isotope synthesis of two potent and selective phosphodiesterase type 4 inhibitors

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Stable isotope synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites

One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

Asymmetric Oxidation of a Dihydrothienopyrimidine

Development of a Practical Process for the Synthesis of PDE4 Inhibitors

Development of a Safe and Economical Synthesis of Methyl 6‑Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale

A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors

A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists

Asymmetric Synthesis of LFA-1 Inhibitor BIRT2584 on Metric Ton Scale

Efficient Multikilogram Synthesis of 5-Bromo-2-cyclopropyl-1-methyl-1H-imidazole

Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

Intramolecular formal [3 + 2] cycloaddition of alkenes and benzylic cations. Stereoselective synthesis of 1,2,3,4,4a,9a-hexahydrofluorenes

Expedient synthesis of substituted imidazoles from nitriles

ChemInform Abstract: One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

Stereoselective synthesis of 1-aryl-4a-methyloctahydrophenanthrenes via cyclization reactions initiated by benzylic cations

Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors

Practical Synthesis of 2-(2-Isopropylaminothiazol-4-yl)-7-methoxy-1H-quinolin-4-one: Key Intermediate for the Synthesis of Potent HCV NS3 Protease Inhibitor BILN 2061

A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins

An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

Synthesis of protected, chiral α,α-disubstituted α-amino acids via a Beckmann rearrangement

Practical synthesis of a cell adhesion inhibitor by self-regeneration of stereocenters

Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1 H -imidazo[1,2- a ]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

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