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Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

European journal of pharmaceutics and biopharmaceutics, 2021-08, Vol.165, p.345-360

2021

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The freezing step in lyophilization: Physico-chemical fundamentals, freezing methods and consequences on process performance and quality attributes of biopharmaceuticals

European journal of pharmaceutics and biopharmaceutics, 2011-06, Vol.78 (2), p.248-263

2011

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Adjustment of specific residual moisture levels in completely freeze-dried protein formulations by controlled spiking of small water volumes

European journal of pharmaceutics and biopharmaceutics, 2021-12, Vol.169, p.292-296

2021

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N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

European journal of pharmaceutics and biopharmaceutics, 2016-03, Vol.100, p.94-100

2016

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Lyophilization cycle design for highly concentrated protein formulations supported by micro freeze-dryer and heat flux sensor

International journal of pharmaceutics, 2023-08, Vol.643, p.123285-123285, Article 123285

2023

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Design of freeze-drying cycles: The determination of heat transfer coefficient by using heat flux sensor and MicroFD

International journal of pharmaceutics, 2022-06, Vol.621, p.121763-121763, Article 121763

2022

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Drug Product Characterization of High Concentration Non-Aqueous Protein Powder Suspensions

Journal of pharmaceutical sciences, 2023-01, Vol.112 (1), p.61-75

2023

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SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs

European journal of pharmaceutics and biopharmaceutics, 2023-01, Vol.182, p.152-156

2023

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Catching Speedy Gonzales: Driving forces for Protein Film Formation on Silicone Rubber Tubing During Pumping

Journal of pharmaceutical sciences, 2022-06, Vol.111 (6), p.1577-1586

2022

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Protein aggregation: Pathways, induction factors and analysis

Journal of pharmaceutical sciences, 2009-09, Vol.98 (9), p.2909-2934

2009

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Topical ocular protein delivery based on protein powder suspensions in semifluorinated alkanes

European journal of pharmaceutics and biopharmaceutics, 2023-08, Vol.189, p.233-239

2023

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Application of interpretable artificial neural networks to early monoclonal antibodies development

European journal of pharmaceutics and biopharmaceutics, 2019-08, Vol.141, p.81-89

2019

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Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates

European journal of pharmaceutics and biopharmaceutics, 2018-06, Vol.127, p.342-354

2018

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Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies

Scientific reports, 2019-10, Vol.9 (1), p.14965-8, Article 14965

2019

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Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.443-451

2020

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Heat flux sensor to create a design space for freeze-drying development

European journal of pharmaceutics and biopharmaceutics, 2020-08, Vol.153, p.84-94

2020

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Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Biotechnology advances, 2015-11, Vol.33 (6), p.1355-1369

2015

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The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface

European journal of pharmaceutics and biopharmaceutics, 2017-10, Vol.119, p.396-407

2017

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Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development

Pharmaceutical research, 2020-02, Vol.37 (2), p.29-29, Article 29

2020

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Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations

European journal of pharmaceutics and biopharmaceutics, 2020-02, Vol.147, p.45-56

2020

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How can we bring high drug doses to the lung?

European journal of pharmaceutics and biopharmaceutics, 2014-01, Vol.86 (1), p.1-6

2014

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Structural properties of monoclonal antibody aggregates induced by freeze–thawing and thermal stress

European journal of pharmaceutical sciences, 2009-09, Vol.38 (2), p.79-87

2009

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IgG1 Adsorption to Siliconized Glass Vials—Influence of pH, Ionic Strength, and Nonionic Surfactants

Journal of pharmaceutical sciences, 2015-01, Vol.104 (1), p.34-43

2015

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Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules

Nanomedicine, 2015-07, Vol.11 (5), p.1179-1187

2015

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Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

Journal of pharmaceutical sciences, 2012-03, Vol.101 (3), p.914-935

2012

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Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

The freezing step in lyophilization: Physico-chemical fundamentals, freezing methods and consequences on process performance and quality attributes of biopharmaceuticals

Adjustment of specific residual moisture levels in completely freeze-dried protein formulations by controlled spiking of small water volumes

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

Lyophilization cycle design for highly concentrated protein formulations supported by micro freeze-dryer and heat flux sensor

Design of freeze-drying cycles: The determination of heat transfer coefficient by using heat flux sensor and MicroFD

Drug Product Characterization of High Concentration Non-Aqueous Protein Powder Suspensions

SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs

Catching Speedy Gonzales: Driving forces for Protein Film Formation on Silicone Rubber Tubing During Pumping

Protein aggregation: Pathways, induction factors and analysis

Topical ocular protein delivery based on protein powder suspensions in semifluorinated alkanes

Application of interpretable artificial neural networks to early monoclonal antibodies development

Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates

Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies

Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction

Heat flux sensor to create a design space for freeze-drying development

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

The film tells the story: Physical-chemical characteristics of IgG at the liquid-air interface

Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development

Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations

How can we bring high drug doses to the lung?

Structural properties of monoclonal antibody aggregates induced by freeze–thawing and thermal stress

IgG1 Adsorption to Siliconized Glass Vials—Influence of pH, Ionic Strength, and Nonionic Surfactants

Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

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