UB Paderborn / Katalog / Suche / in CDI

Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106596-106596, Article 106596

2019

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Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms

Toxicological sciences, 2016-09, Vol.153 (1), p.39-54

2016

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Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Journal of pharmacological and toxicological methods, 2016-01, Vol.77, p.24-32

2016

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Non-clinical evaluation of ventricular repolarization (ICH S7B): Results of an interim survey of international pharmaceutical companies

Journal of pharmacological and toxicological methods, 2005-07, Vol.52 (1), p.6-11

2005

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Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

International journal of toxicology, 2024-06, Vol.43 (3), p.231-242

2024

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Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107527, Article 107527

2024

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Respiratory Rates Derived From Arterial Blood Pressure Waveforms in Telemetered Dogs

International journal of toxicology, 2020-11, Vol.39 (6), p.542-546

2020

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Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.710

2005

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Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106897, Article 106897

2020

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International journal of toxicology, 2019-01, Vol.38 (1), p.23-32

2019

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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

International journal of toxicology, 2020-07, Vol.39 (4), p.274-293

2020

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Benchmarking Safety Pharmacology regulatory packages and best practice

Journal of pharmacological and toxicological methods, 2008-09, Vol.58 (2), p.99-109

2008

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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3477-3480

2004

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Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia

Journal of cardiovascular pharmacology, 2002-01, Vol.39 (1), p.18-28

2002

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The Pathway-selective Estrogen Receptor Ligand WAY-169916 Displays Differential Activity in Ischemia-Reperfusion Injury Models

Journal of cardiovascular pharmacology, 2006-06, Vol.47 (6), p.788-795

2006

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The complement system in myocardial ischaemia/reperfusion injury

Cardiovascular research, 1994-04, Vol.28 (4), p.437-444

1994

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Antiarrhythmic versus antifibrillatory actions: Inference from experimental studies

The American journal of cardiology, 1993-11, Vol.72 (16), p.F25-F44

1993

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Effects of Heparin and N-Acetyl Heparin on Ischemia/Reperfusion-Induced Alterations in Myocardial Function in the Rabbit Isolated Heart

Circulation research, 1994-10, Vol.75 (4), p.701-710

1994

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Antiarrhythmic Agent, MS-551, Protects Against Pinacidil + Hypoxia-Induced Ventricular Fibrillation in Langendorff-Perfused Rabbit Isolated Heart

Journal of cardiovascular pharmacology, 1994-01, Vol.23 (1), p.120-126

1994

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Experimental models of atrial fibrillation/flutter

Journal of pharmacological and toxicological methods, 2000-03, Vol.43 (2), p.117-123

Friedrichs, Gregory S

2000

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Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (15), p.1967-1971

2002

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Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.151-152

2018

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Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis

Circulation (New York, N.Y.), 1994-11, Vol.90 (5), p.2448-2456

1994

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Cardiovascular data acquisition and analysis: An SPS industry survey

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106749, Article 106749

2020

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JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortium

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.121-121

2018

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Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events

Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms

Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Non-clinical evaluation of ventricular repolarization (ICH S7B): Results of an interim survey of international pharmaceutical companies

Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone

Respiratory Rates Derived From Arterial Blood Pressure Waveforms in Telemetered Dogs

Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis

Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation

Benchmarking Safety Pharmacology regulatory packages and best practice

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia

The Pathway-selective Estrogen Receptor Ligand WAY-169916 Displays Differential Activity in Ischemia-Reperfusion Injury Models

The complement system in myocardial ischaemia/reperfusion injury

Antiarrhythmic versus antifibrillatory actions: Inference from experimental studies

Effects of Heparin and N-Acetyl Heparin on Ischemia/Reperfusion-Induced Alterations in Myocardial Function in the Rabbit Isolated Heart

Antiarrhythmic Agent, MS-551, Protects Against Pinacidil + Hypoxia-Induced Ventricular Fibrillation in Langendorff-Perfused Rabbit Isolated Heart

Experimental models of atrial fibrillation/flutter

Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects

Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation

Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis

Cardiovascular data acquisition and analysis: An SPS industry survey

JTp and Tpe as Biomarkers of proarrhythmic risk in nonclinical models: Historical data evaluation by the HESI consortium

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