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The molecular mechanisms behind activation of FLT3 in acute myeloid leukemia and resistance to therapy by selective inhibitors

Biochimica et biophysica acta. Reviews on cancer, 2022-01, Vol.1877 (1), p.188666-188666, Article 188666

Friedman, Ran

2022

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Drug resistance in cancer: molecular evolution and compensatory proliferation

Oncotarget, 2016-03, Vol.7 (11), p.11746-11755

Friedman, Ran

2016

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Drug resistance missense mutations in cancer are subject to evolutionary constraints

PloS one, 2013-12, Vol.8 (12), p.e82059

2013

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Ions and the Protein Surface Revisited: Extensive Molecular Dynamics Simulations and Analysis of Protein Structures in Alkali-Chloride Solutions

The journal of physical chemistry. B, 2011-07, Vol.115 (29), p.9213-9223

Friedman, Ran

2011

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Combination strategies to overcome drug resistance in FLT + acute myeloid leukaemia

Cancer cell international, 2023-08, Vol.23 (1), p.161-161, Article 161

2023

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Computer simulations of the signalling network in FLT3 + -acute myeloid leukaemia - indications for an optimal dosage of inhibitors against FLT3 and CDK6

BMC bioinformatics, 2018-04, Vol.19 (1), p.155-155, Article 155

2018

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Multistep orthophosphate release tunes actomyosin energy transduction

Nature communications, 2022-08, Vol.13 (1), p.4575-4575, Article 4575

2022

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Wordom: A user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces

Journal of computational chemistry, 2011-04, Vol.32 (6), p.1183-1194

2011

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Inferring time-dependent population growth rates in cell cultures undergoing adaptation

BMC bioinformatics, 2020-12, Vol.21 (1), p.583-583, Article 583

2020

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Rotating between ponatinib and imatinib temporarily increases the efficacy of imatinib as shown in a chronic myeloid leukaemia model

Scientific reports, 2022-03, Vol.12 (1), p.5164-5164, Article 5164

2022

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Dilution of whisky - the molecular perspective

Scientific reports, 2017-08, Vol.7 (1), p.6489-9, Article 6489

2017

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A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy

BMC cancer, 2018-05, Vol.18 (1), p.569-8, Article 569

2018

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The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

BMC cancer, 2020-05, Vol.20 (1), p.397-14, Article 397

2020

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Estimating the Gibbs Hydration Energies of Actinium and Trans‐Plutonium Actinides

Chemphyschem, 2023-01, Vol.24 (2), p.e202200516-n/a

Friedman, Ran

2023

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Preferential Binding of Lanthanides to Methanol Dehydrogenase Evaluated with Density Functional Theory

The journal of physical chemistry. B, 2021-03, Vol.125 (9), p.2251-2257

Friedman, Ran

2021

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Computational studies of protein–drug binding affinity changes upon mutations in the drug target

Wiley interdisciplinary reviews. Computational molecular science, 2022-01, Vol.12 (1), p.e1563-n/a

Friedman, Ran

2022

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Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

PloS one, 2016-09, Vol.11 (9), p.e0163011-e0163011

2016

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Membrane–Ion Interactions

The Journal of membrane biology, 2018-06, Vol.251 (3), p.453-460

Friedman, Ran

2018

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The molecular mechanism behind resistance of the kinase FLT3 to the inhibitor quizartinib

Proteins, structure, function, and bioinformatics, 2017-11, Vol.85 (11), p.2143-2152

Friedman, Ran

2017

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Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

The Journal of membrane biology, 2015-08, Vol.248 (4), p.611-640

2015

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Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes

PloS one, 2016-05, Vol.11 (5), p.e0155287-e0155287

2016

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Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemia

BMC cancer, 2019-05, Vol.19 (1), p.508-508, Article 508

2019

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Acute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy

International journal of molecular sciences, 2015-05, Vol.16 (5), p.11659-11677

2015

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Combating drug resistance in acute myeloid leukaemia by drug rotations: the effects of quizartinib and pexidartinib

Cancer cell international, 2021-04, Vol.21 (1), p.198-198, Article 198

2021

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Reverse engineering directed gene regulatory networks from transcriptomics and proteomics data of biomining bacterial communities with approximate Bayesian computation and steady-state signalling simulations

BMC bioinformatics, 2020-01, Vol.21 (1), p.23-23, Article 23

2020

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The molecular mechanisms behind activation of FLT3 in acute myeloid leukemia and resistance to therapy by selective inhibitors

Drug resistance in cancer: molecular evolution and compensatory proliferation

Drug resistance missense mutations in cancer are subject to evolutionary constraints

Ions and the Protein Surface Revisited: Extensive Molecular Dynamics Simulations and Analysis of Protein Structures in Alkali-Chloride Solutions

Combination strategies to overcome drug resistance in FLT + acute myeloid leukaemia

Computer simulations of the signalling network in FLT3 + -acute myeloid leukaemia - indications for an optimal dosage of inhibitors against FLT3 and CDK6

Multistep orthophosphate release tunes actomyosin energy transduction

Wordom: A user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces

Inferring time-dependent population growth rates in cell cultures undergoing adaptation

Rotating between ponatinib and imatinib temporarily increases the efficacy of imatinib as shown in a chronic myeloid leukaemia model

Dilution of whisky - the molecular perspective

A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy

The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

Estimating the Gibbs Hydration Energies of Actinium and Trans‐Plutonium Actinides

Preferential Binding of Lanthanides to Methanol Dehydrogenase Evaluated with Density Functional Theory

Computational studies of protein–drug binding affinity changes upon mutations in the drug target

Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

Membrane–Ion Interactions

The molecular mechanism behind resistance of the kinase FLT3 to the inhibitor quizartinib

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes

Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemia

Acute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy

Combating drug resistance in acute myeloid leukaemia by drug rotations: the effects of quizartinib and pexidartinib

Reverse engineering directed gene regulatory networks from transcriptomics and proteomics data of biomining bacterial communities with approximate Bayesian computation and steady-state signalling simulations

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