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From single target to multitarget/network therapeutics in Alzheimer's therapy

Pharmaceuticals, 2014-01, Vol.7 (2), p.113-135

2014

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Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

PloS one, 2016-07, Vol.11 (7), p.e0158352-e0158352

2016

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Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Pharmaceutics, 2021-12, Vol.14 (1), p.71

2021

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Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

PloS one, 2018-08, Vol.13 (8), p.e0200615-e0200615

2018

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Tuftsin-Phosphorylcholine Maintains Normal Gut Microbiota in Collagen Induced Arthritic Mice

Frontiers in microbiology, 2017-07, Vol.8, p.1222-1222

2017

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New Approaches to Treating Alzheimer's Disease

Perspectives in medicinal chemistry, 2015-01, Vol.2015 (7), p.1-8

2015

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Therapeutic Potential of Vasoactive Intestinal Peptide and its Derivative Stearyl-Norleucine-VIP in Inflammation-Induced Osteolysis

Frontiers in pharmacology, 2021-05, Vol.12, p.638128-638128

2021

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Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy

ACS chemical biology, 2010-06, Vol.5 (6), p.603-610

2010

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Novel multifunctional neuroprotective iron chelator‐monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

Journal of neurochemistry, 2005-10, Vol.95 (1), p.68-78

2005

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Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases

Bioorganic & medicinal chemistry, 2005-02, Vol.13 (3), p.773-783

2005

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Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators

The FASEB journal, 2007-12, Vol.21 (14), p.3835-3844

2007

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Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome

The Journal of clinical investigation, 2002-03, Vol.109 (6), p.797-804

2002

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Helminth-Based Product and the Microbiome of Mice with Lupus

mSystems, 2019-01, Vol.4 (1)

2019

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Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

Pharmaceutics, 2021-09, Vol.13 (10), p.1557

2021

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The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model

International immunology, 2007-07, Vol.19 (7), p.857-865

2007

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Prolonging the Action of Protein and Peptide Drugs by a Novel Approach of Reversible Polyethylene Glycol Modification

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.38118-38124

2004

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Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG

Current Alzheimer research, 2007-09, Vol.4 (4), p.403-411

2007

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Novel Chelators Targeting Cell Cycle Arrest, Acetylcholinesterase, and Monoamine Oxidase for Alzheimer's Therapy

Current drug targets, 2012-07, Vol.13 (8), p.1096-1113

2012

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Structure−Function Studies of Polymyxin B Nonapeptide: Implications to Sensitization of Gram-Negative Bacteria

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3085-3092

2000

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Death-associated Protein (DAP) Kinase Plays a Central Role in Ceramide-induced Apoptosis in Cultured Hippocampal Neurons

The Journal of biological chemistry, 2002-01, Vol.277 (3), p.1957-1961

2002

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NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death

Stroke (1970), 2002-04, Vol.33 (4), p.1085-1092

2002

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Subtle differences in structural transitions between poly-L- and poly-D-amino acids of equal length in water

Physical chemistry chemical physics : PCCP, 2006-01, Vol.8 (3), p.333-339

2006

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Insulin-like effects of vanadium: basic and clinical implications

Journal of inorganic biochemistry, 2000-05, Vol.80 (1), p.21-25

2000

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Prevention of Experimental Antiphospholipid Syndrome and Endothelial Cell Activation by Synthetic Peptides

Proceedings of the National Academy of Sciences - PNAS, 1999-04, Vol.96 (9), p.5164-5168

1999

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Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice

FEBS letters, 2005-04, Vol.579 (11), p.2439-2444

2005

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From single target to multitarget/network therapeutics in Alzheimer's therapy

Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations

Albumin-Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis

Tuftsin-Phosphorylcholine Maintains Normal Gut Microbiota in Collagen Induced Arthritic Mice

New Approaches to Treating Alzheimer's Disease

Therapeutic Potential of Vasoactive Intestinal Peptide and its Derivative Stearyl-Norleucine-VIP in Inflammation-Induced Osteolysis

Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy

Novel multifunctional neuroprotective iron chelator‐monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases

Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators

Bacterial induction of autoantibodies to β2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome

Helminth-Based Product and the Microbiome of Mice with Lupus

Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis

The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model

Prolonging the Action of Protein and Peptide Drugs by a Novel Approach of Reversible Polyethylene Glycol Modification

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG

Novel Chelators Targeting Cell Cycle Arrest, Acetylcholinesterase, and Monoamine Oxidase for Alzheimer's Therapy

Structure−Function Studies of Polymyxin B Nonapeptide: Implications to Sensitization of Gram-Negative Bacteria

Death-associated Protein (DAP) Kinase Plays a Central Role in Ceramide-induced Apoptosis in Cultured Hippocampal Neurons

NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death

Subtle differences in structural transitions between poly-L- and poly-D-amino acids of equal length in water

Insulin-like effects of vanadium: basic and clinical implications

Prevention of Experimental Antiphospholipid Syndrome and Endothelial Cell Activation by Synthetic Peptides

Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice

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