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Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6233-6243

2009

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On The Rate and Extent of Drug Delivery to the Brain

Pharmaceutical research, 2008-08, Vol.25 (8), p.1737-1750

2008

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Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.353-362

2011

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Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Drug discovery today, 2019-05, Vol.24 (5), p.1067-1073

2019

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Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Critical reviews in toxicology, 2019-02, Vol.49 (2), p.160-173

2019

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Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Journal of pharmaceutical sciences, 2017-09, Vol.106 (9), p.2234-2244

2017

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Exploring In Silico Prediction of the Unbound Brain-to-Plasma Drug Concentration Ratio: Model Validation, Renewal, and Interpretation

Journal of pharmaceutical sciences, 2015-03, Vol.104 (3), p.1197-1206

2015

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Uncovering the regional localization of inhaled salmeterol retention in the lung

Drug delivery, 2018, Vol.25 (1), p.838-845

2018

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Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Journal of aerosol medicine and pulmonary drug delivery, 2019-02, Vol.32 (1), p.1-12

2019

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Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

EJNMMI research, 2019-01, Vol.9 (1), p.9-10, Article 9

2019

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Professor Margareta Hammarlund-Udenaes – a Modern and Visionary Mentor

Pharmaceutical research, 2022-07, Vol.39 (7), p.1291-1296

2022

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Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

Journal of pharmaceutical sciences, 2019-10, Vol.108 (10), p.3425-3433

2019

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In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Drug metabolism and disposition, 2007-09, Vol.35 (9), p.1711-1719

2007

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Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

European journal of pharmaceutical sciences, 2016-09, Vol.92, p.173-182

2016

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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Pharmaceutical research, 2022-07, Vol.39 (7), p.1321-1341

2022

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Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Journal of cerebral blood flow and metabolism, 2010-01, Vol.30 (1), p.150-161

2010

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Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Journal of pharmaceutical sciences, 2016-11, Vol.105 (11), p.3432-3439

2016

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Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Pharmaceutical research, 2017-12, Vol.34 (12), p.2557-2567

2017

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Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

British journal of pharmacology, 2021-11, Vol.178 (22), p.4440-4451

2021

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Methodologies to assess brain drug delivery in lead optimization

Current topics in medicinal chemistry, 2009-02, Vol.9 (2), p.148-162

2009

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The brain slice method for studying drug distribution in the CNS

Fluids and barriers of the CNS, 2013-01, Vol.10 (1), p.6-6, Article 6

2013

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Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.838-845

2016

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Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

Drug metabolism and disposition, 2009-06, Vol.37 (6), p.1226-1233

2009

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In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

Journal of molecular graphics & modelling, 2011-08, Vol.29 (8), p.985-995

2011

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A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.279-287

2015

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Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

On The Rate and Extent of Drug Delivery to the Brain

Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs

Exploring In Silico Prediction of the Unbound Brain-to-Plasma Drug Concentration Ratio: Model Validation, Renewal, and Interpretation

Uncovering the regional localization of inhaled salmeterol retention in the lung

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator

Professor Margareta Hammarlund-Udenaes – a Modern and Visionary Mentor

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation

Methodologies to assess brain drug delivery in lead optimization

The brain slice method for studying drug distribution in the CNS

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships

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