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Pivotal Role of Translation in Anti‐Infective Development

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.856-866

Friberg, Lena E.

2021

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Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation

International journal of antimicrobial agents, 2024-08, Vol.64 (2), p.107236, Article 107236

2024

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From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.928

2021

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Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs

Pharmacological reviews, 2013-07, Vol.65 (3), p.1053

2013

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Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects

International journal of antimicrobial agents, 2022-09, Vol.60 (3), p.106616-106616, Article 106616

2022

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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.928-941

2021

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Colistin Is Extensively Lost during Standard In Vitro Experimental Conditions

Antimicrobial agents and chemotherapy, 2017-11, Vol.61 (11)

2017

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Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

International journal of antimicrobial agents, 2020-09, Vol.56 (3), p.106059-106059, Article 106059

2020

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Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization

Antimicrobial Agents and Chemotherapy, 2011-10, Vol.55 (10), p.4619-4630

2011

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Model-based Dose Individualization of Sunitinib in Gastrointestinal Stromal Tumors

Clinical cancer research, 2020-09, Vol.26 (17), p.4590-4598

2020

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Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

Antimicrobial agents and chemotherapy, 2020-06, Vol.64 (7)

2020

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How preclinical infection models help define antibiotic doses in the clinic

International journal of antimicrobial agents, 2020-08, Vol.56 (2), p.106008, Article 106008

2020

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Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors

Frontiers in pharmacology, 2020-03, Vol.11, p.316-316

2020

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Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

Antimicrobial agents and chemotherapy, 2020-03, Vol.64 (4)

2020

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Model-Informed Precision Dosing to Reduce Vincristine-Induced Peripheral Neuropathy in Pediatric Patients: A Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis

Clinical pharmacokinetics, 2024-02, Vol.63 (2), p.197-209

2024

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Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Cytokine (Philadelphia, Pa.), 2023-09, Vol.169, p.156296-156296, Article 156296

2023

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Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults

Antimicrobial Agents and Chemotherapy, 2012-06, Vol.56 (6), p.3032-3042

2012

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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time–kill experiments: agreement with in silico predictions

Journal of antimicrobial chemotherapy, 2024-02, Vol.79 (2), p.391-402

2024

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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Clinical microbiology and infection, 2022-10, Vol.28 (10), p.1367-1374

2022

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Predicting the Long‐Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis

Clinical pharmacology and therapeutics, 2024-09, Vol.116 (3), p.703-715

2024

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Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Antimicrobial agents and chemotherapy, 2020-05, Vol.64 (6)

2020

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Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill

Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4241-4249

2012

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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

Journal of antimicrobial chemotherapy, 2022-09, Vol.77 (10), p.2718-2728

2022

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Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response

British journal of clinical pharmacology, 2015-01, Vol.79 (1), p.56-71

2015

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Pivotal Role of Translation in Anti‐Infective Development

Impact of continuous-infusion meropenem degradation and infusion bag changes on bacterial killing of Pseudomonas aeruginosa based on model-informed translation

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs

Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Colistin Is Extensively Lost during Standard In Vitro Experimental Conditions

Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Pharmacokinetic/Pharmacodynamic (PK/PD) Indices of Antibiotics Predicted by a Semimechanistic PKPD Model: a Step toward Model-Based Dose Optimization

Model-based Dose Individualization of Sunitinib in Gastrointestinal Stromal Tumors

Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

How preclinical infection models help define antibiotic doses in the clinic

Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial

Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime

Model-Informed Precision Dosing to Reduce Vincristine-Induced Peripheral Neuropathy in Pediatric Patients: A Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis

Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Integrated Population Pharmacokinetic Analysis of Voriconazole in Children, Adolescents, and Adults

Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time–kill experiments: agreement with in silico predictions

Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia

Predicting the Long‐Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis

Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill

Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

Population pharmacokinetic–pharmacodynamic modelling in oncology: a tool for predicting clinical response

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