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Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Nature medicine, 2019-03, Vol.25 (3), p.423-426

2019

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Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

American journal of human genetics, 2011-05, Vol.88 (5), p.650-656

2011

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Nature, 2005-09, Vol.437 (7058), p.564-568

2005

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USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

Cell death & disease, 2023-01, Vol.14 (1), p.60-60, Article 60

2023

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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

The Journal of cell biology, 2008-04, Vol.181 (1), p.27-35

2008

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Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Nature medicine, 2019-08, Vol.25 (8), p.1234-1242

2019

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A conserved splicing mechanism of the LMNA gene controls premature aging

Human molecular genetics, 2011-12, Vol.20 (23), p.4540-4555

2011

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Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (37), p.16268-16273

2010

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The hallmarks of aging as a conceptual framework for health and longevity research

Frontiers in aging, 2024, Vol.5, p.1334261-1334261

2024

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Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

Nature medicine, 2016-01, Vol.22 (1), p.91-96

2016

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Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

The EMBO journal, 2011-06, Vol.30 (11), p.2219-2232

2011

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Premature aging in mice activates a systemic metabolic response involving autophagy induction

Human molecular genetics, 2008-07, Vol.17 (14), p.2196-2211

2008

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NF-κB activation impairs somatic cell reprogramming in ageing

Nature cell biology, 2015-08, Vol.17 (8), p.1004

2015

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Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

Human molecular genetics, 2013-06, Vol.22 (11), p.2273-2282

2013

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

Nature Medicine, 2008-07, Vol.14 (7), p.767-772

2008

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Splicing-directed therapy in a new mouse model of human accelerated aging

Science translational medicine, 2011-10, Vol.3 (106), p.106ra107

2011

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Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

The Journal of clinical investigation, 2016-10, Vol.126 (10), p.3879-3893

2016

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Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Aging cell, 2010-12, Vol.9 (6), p.947-957

2010

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Protein Kinase C θ Is Highly Expressed in Gastrointestinal Stromal Tumors But Not in Other Mesenchymal Neoplasias

Clinical cancer research, 2004-06, Vol.10 (12), p.4089-4095

2004

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The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

PLoS biology, 2018-10, Vol.16 (10), p.e2006247-e2006247

2018

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Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice

The Journal of biological chemistry, 2018-02, Vol.293 (6), p.2183-2194

2018

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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

Journal of cellular physiology, 2015-01, Vol.230 (1), p.191-198

2015

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USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer

The Journal of biological chemistry, 2017-03, Vol.292 (10), p.4164-4175

2017

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Accelerated ageing: from mechanism to therapy through animal models

Transgenic research, 2009-02, Vol.18 (1), p.7-15

2009

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Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

A conserved splicing mechanism of the LMNA gene controls premature aging

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

The hallmarks of aging as a conceptual framework for health and longevity research

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

Premature aging in mice activates a systemic metabolic response involving autophagy induction

NF-κB activation impairs somatic cell reprogramming in ageing

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

Splicing-directed therapy in a new mouse model of human accelerated aging

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Protein Kinase C θ Is Highly Expressed in Gastrointestinal Stromal Tumors But Not in Other Mesenchymal Neoplasias

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function

Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice

Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer

Accelerated ageing: from mechanism to therapy through animal models

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