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Lactococcus lactis Delivery of Surface Layer Protein A Protects Mice from Colitis by Re-Setting Host Immune Repertoire

Biomedicines, 2021-08, Vol.9 (9), p.1098

2021

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Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

Behavioural brain research, 2020-08, Vol.392, p.112701-112701, Article 112701

2020

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

Nature medicine, 2011-11, Vol.17 (11), p.1490

2011

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P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

The Journal of clinical investigation, 2011-07, Vol.121 (7), p.2932-2944

2011

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Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles

The Journal of clinical investigation, 2015-04, Vol.125 (4), p.1471-1484

2015

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Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease

Scientific reports, 2023-11, Vol.13 (1), p.19489-19489, Article 19489

2023

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Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Blood, 2009-03, Vol.113 (12), p.2859-2866

2009

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Current Concepts for the IND-Directed Development of Microbicide Products to Prevent the Sexual Transmission of HIV

Current topics in medicinal chemistry, 2016-01, Vol.16 (10), p.1118

2016

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Emerging role of regulatory T cells in gene transfer

Current gene therapy, 2007-10, Vol.7 (5), p.381

2007

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Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

Nature, 2008-04, Vol.452 (7187), p.654-658

2008

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1140 – Syn-007, an Oral Beta-Lactamase Prevents Gut Microbime Dysbiosis Caused by Oral Amoxicillin and Oral Amoxicillin/Clavulanate Without Affecting Amoxicillin Systemic Absorption in Dogs

Gastroenterology (New York, N.Y. 1943), 2019-05, Vol.156 (6), p.S-241-S-242

2019

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Sa1839 - Orally Delivered Beta-Lactamase Prevents Gut Microbiome Dysbiosis Caused by IV and Oral Antibiotics and Mitigates Propagation of Antibiotic Resistance in Porcine and Canine Models

Gastroenterology (New York, N.Y. 1943), 2018-05, Vol.154 (6), p.S-415-S-415

2018

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Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s)

Haematologica (Roma), 2004-12, Vol.89 (12), p.1504

2004

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332g - An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S1305-S1306

2017

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Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor

Arteriosclerosis, thrombosis, and vascular biology, 2013-04, Vol.33 (4), p.769

2013

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Variation of factor VII 140s and 170s loops in fishes: evolutionary aspects and comparison with mutations found in FVII deficiency

Thrombosis and haemostasis, 2003-12, Vol.90 (6), p.1220

2003

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An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S1305-S1306

2017

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Vascular and dendritic cell coagulation signaling in sepsis progression

Journal of thrombosis and haemostasis, 2009-07, Vol.7 (Suppl 1), p.118-121

2009

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673. Novel Delayed-Release Formulation of an Oral β-Lactamase Prevents Gut Microbiome Damage and Attenuates Antibiotic Resistance Caused by Oral Amoxicillin/Clavulanate without Interfering with Amoxicillin Systemic Absorption in Dogs

Open forum infectious diseases, 2019-10, Vol.6 (Supplement_2), p.S307-S307

2019

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A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

Blood, 2014-12, Vol.124 (21), p.2806-2806

2014

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620. Oral β-Lactamase Therapies Prevent Microbiome Damage and Attenuate Antibiotic Resistance From IV and Oral Antibiotics in Large Animal Models of Antibiotic-Mediated Gut Dysbiosis

Open forum infectious diseases, 2018-11, Vol.5 (suppl_1), p.S226-S226

2018

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Inflammation, Obesity, and Thrombosis

Blood, 2012-11, Vol.120 (21), p.SCI-45-SCI-45

2012

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Gut Antibiotic Inactivation by Β-Lactamases Is Intended to Prevent Microbiome Damage and Attenuate Antibiotic Resistance in Large Animal Models

Open forum infectious diseases, 2017-10, Vol.4 (suppl_1), p.S232-S233

2017

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SYN-006, a Novel Carbapenemase, Intended to Protect the Gut Microbiome from Antibiotic-Mediated Damage May Also Reduce Propagation of Carbapenem-Resistant Pathogens

Open forum infectious diseases, 2017-10, Vol.4 (suppl_1), p.S231-S232

2017

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Lactococcus lactis Delivery of Surface Layer Protein A Protects Mice from Colitis by Re-Setting Host Immune Repertoire

Maternal treatment with oral intestinal alkaline phosphatase mitigates high fat diet-induced cognitive disorders in offspring mice

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles

Treatment with a Lactococcus lactis that chromosomally express E. coli cfaI mitigates salivary flow loss in a Sjögren's syndrome-like disease

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Current Concepts for the IND-Directed Development of Microbicide Products to Prevent the Sexual Transmission of HIV

Emerging role of regulatory T cells in gene transfer

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

1140 – Syn-007, an Oral Beta-Lactamase Prevents Gut Microbime Dysbiosis Caused by Oral Amoxicillin and Oral Amoxicillin/Clavulanate Without Affecting Amoxicillin Systemic Absorption in Dogs

Sa1839 - Orally Delivered Beta-Lactamase Prevents Gut Microbiome Dysbiosis Caused by IV and Oral Antibiotics and Mitigates Propagation of Antibiotic Resistance in Porcine and Canine Models

Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s)

332g - An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor

Variation of factor VII 140s and 170s loops in fishes: evolutionary aspects and comparison with mutations found in FVII deficiency

An Orally Delivered Beta-Lactamase Protects the Gut Microbiome from Antibiotic-Mediated Damage and Mitigates the Propagation of Antibiotic-Resistance Genes in a Porcine Dysbiosis Model

Vascular and dendritic cell coagulation signaling in sepsis progression

673. Novel Delayed-Release Formulation of an Oral β-Lactamase Prevents Gut Microbiome Damage and Attenuates Antibiotic Resistance Caused by Oral Amoxicillin/Clavulanate without Interfering with Amoxicillin Systemic Absorption in Dogs

A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release

620. Oral β-Lactamase Therapies Prevent Microbiome Damage and Attenuate Antibiotic Resistance From IV and Oral Antibiotics in Large Animal Models of Antibiotic-Mediated Gut Dysbiosis

Inflammation, Obesity, and Thrombosis

Gut Antibiotic Inactivation by Β-Lactamases Is Intended to Prevent Microbiome Damage and Attenuate Antibiotic Resistance in Large Animal Models

SYN-006, a Novel Carbapenemase, Intended to Protect the Gut Microbiome from Antibiotic-Mediated Damage May Also Reduce Propagation of Carbapenem-Resistant Pathogens

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