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The role of glutathione in brain tumor drug resistance

Biochemical pharmacology, 2012-04, Vol.83 (8), p.1005-1012

2012

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Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Molecular aspects of medicine, 2009-02, Vol.30 (1), p.86-98

2009

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Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

The Journal of biological chemistry, 2010-05, Vol.285 (21), p.16116-16124

2010

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Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells

The Journal of biological chemistry, 1997-07, Vol.272 (27), p.16917-16923

1997

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Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

Journal of Toxicology, 2012-01, Vol.2012, p.207594-12

2012

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Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

Neurochemical research, 2013-09, Vol.38 (9), p.1838-1849

2013

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Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

Archives of biochemistry and biophysics, 2004-03, Vol.423 (1), p.116-125

2004

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Conditional Expression of Mitogen-Activated Protein Kinase Phosphatase-1, MKP-1, is Cytoprotective against UV-Induced Apoptosis

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (6), p.3014-3019

1998

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Adenoviral Overexpression of the Glutamylcysteine Ligase Catalytic Subunit Protects Pancreatic Islets against Oxidative Stress

The Journal of biological chemistry, 2004-12, Vol.279 (52), p.53988-53993

2004

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Caspase-3-Dependent Cleavage of the Glutamate- l-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death

The American journal of pathology, 2002-05, Vol.160 (5), p.1887-1894

2002

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A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis

Journal of medicinal chemistry, 2012-02, Vol.55 (3), p.1382-1388

2012

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Posttranslational modification and regulation of glutamate–cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

Free radical biology & medicine, 2011, Vol.50 (1), p.14-26

2011

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Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis

American journal of physiology. Lung cellular and molecular physiology, 2007-06, Vol.292 (6), p.L1572-L1579

2007

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Enhanced glutathione biosynthetic capacity promotes resistance to As3+-induced apoptosis

Toxicology letters, 2010-03, Vol.193 (1), p.33-40

2010

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2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways

Free radical biology & medicine, 2011-09, Vol.51 (6), p.1146-1154

2011

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TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms

The FASEB journal, 2003-08, Vol.17 (11), p.1535-1537

2003

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Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity

Toxicology and applied pharmacology, 2010-02, Vol.243 (1), p.35-45

2010

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Disruption of Redox Homeostasis in Tumor Necrosis Factor-Induced Apoptosis in a Murine Hepatocyte Cell Line

The American journal of pathology, 2000-07, Vol.157 (1), p.221-236

2000

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Methods to Detect Protein Glutathionylation

Current Protocols in Toxicology, 2013-08, Vol.57 (1), p.6.17.1-6.17.18

2013

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Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Free radical biology & medicine, 2004-09, Vol.37 (5), p.632-642

2004

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Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes

Free radical biology & medicine, 2009-06, Vol.46 (12), p.1614-1625

2009

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Cell culture model for acetaminophen-induced hepatocyte death in vivo

Biochemical pharmacology, 2002-08, Vol.64 (3), p.413-424

2002

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Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis

Molecular and cellular biochemistry, 1999-09, Vol.199 (1-2), p.169

1999

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TGFβ1‐induced suppression of glutathione antioxidant defenses in hepatocytes: caspase‐dependent posttranslational and caspase‐independent transcriptional regulatory mechanisms

The FASEB journal, 2003-08, Vol.17 (11), p.1-23

2003

Volltextzugriff (PDF)

Phorbol Ester-Induced Amino-Terminal Phosphorylation of Human JUN but not JUNB Regulates Transcriptional Activation

Proceedings of the National Academy of Sciences - PNAS, 1992-08, Vol.89 (15), p.7247-7251

1992

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The role of glutathione in brain tumor drug resistance

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

Conditional Expression of the Mitogen-activated Protein Kinase (MAPK) Phosphatase MKP-1 Preferentially Inhibits p38 MAPK and Stress-activated Protein Kinase in U937 Cells

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

Glycation of Glutamate Cysteine Ligase by 2-Deoxy-d-Ribose and its Potential Impact on Chemoresistance in Glioblastoma

Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

Conditional Expression of Mitogen-Activated Protein Kinase Phosphatase-1, MKP-1, is Cytoprotective against UV-Induced Apoptosis

Adenoviral Overexpression of the Glutamylcysteine Ligase Catalytic Subunit Protects Pancreatic Islets against Oxidative Stress

Caspase-3-Dependent Cleavage of the Glutamate- l-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death

A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis

Posttranslational modification and regulation of glutamate–cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis

Enhanced glutathione biosynthetic capacity promotes resistance to As3+-induced apoptosis

2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways

TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity

Disruption of Redox Homeostasis in Tumor Necrosis Factor-Induced Apoptosis in a Murine Hepatocyte Cell Line

Methods to Detect Protein Glutathionylation

Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis

Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes

Cell culture model for acetaminophen-induced hepatocyte death in vivo

Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis

TGFβ1‐induced suppression of glutathione antioxidant defenses in hepatocytes: caspase‐dependent posttranslational and caspase‐independent transcriptional regulatory mechanisms

Phorbol Ester-Induced Amino-Terminal Phosphorylation of Human JUN but not JUNB Regulates Transcriptional Activation

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