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The Methylation Effect in Medicinal Chemistry

Chemical reviews, 2011-09, Vol.111 (9), p.5215-5246

2011

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Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7525-7545

2012

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Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile

Pharmaceuticals (Basel, Switzerland), 2024-03, Vol.17 (3), p.389

2024

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Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes

Bioorganic & medicinal chemistry, 2009, Vol.17 (1), p.74-84

2009

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Design, Synthesis, and Pharmacological Evaluation of Novel N‑Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors

Journal of medicinal chemistry, 2016-01, Vol.59 (2), p.655-670

2016

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Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases

Pharmaceuticals (Basel, Switzerland), 2019-05, Vol.12 (2), p.69

2019

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New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia

Behavioural brain research, 2013-01, Vol.237, p.86-95

2013

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Understanding the Structural Basis of ALDH-2 Inhibition by Molecular Docking

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2016-09, Vol.12 (6), p.506-512

2016

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NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives

Current drug targets, 2018-01, Vol.19 (16), p.1933-1942

2018

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The Use of Conformational Restriction in Medicinal Chemistry

Current topics in medicinal chemistry, 2019-01, Vol.19 (19), p.1712-1733

2019

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Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres: A New Class of Potent and Selective Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1144-1152

2003

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Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.74-77

2010

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Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4963-4966

2009

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Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties

PloS one, 2016-05, Vol.11 (5), p.e0156271-e0156271

2016

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Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety

New journal of chemistry, 2020-07, Vol.44 (26), p.1994-115

2020

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Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

European journal of medicinal chemistry, 2012-08, Vol.54, p.512-521

2012

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Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

European journal of medicinal chemistry, 2009-10, Vol.44 (10), p.4004-4009

2009

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N -acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity

International journal of cardiology, 2014-05, Vol.173 (2), p.154-162

2014

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N-Acylhydrazones as drugs

Bioorganic & medicinal chemistry letters, 2018-09, Vol.28 (17), p.2797-2806

2018

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Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs

Current medicinal chemistry, 2006, Vol.13 (2), p.167-198

2006

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Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC–MS/MS: Application for a pharmacokinetic study

Journal of pharmaceutical and biomedical analysis, 2011-07, Vol.55 (5), p.1024-1030

2011

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Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies

PloS one, 2014-03, Vol.9 (3), p.e91660-e91660

2014

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Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl- N -Acylhydrazone Derivative

Pharmaceuticals (Basel, Switzerland), 2018-11, Vol.11 (4), p.119

2018

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Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (23), p.7924-7935

2006

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Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats

Clinical and experimental pharmacology & physiology, 2013-07, Vol.40 (7), p.404-411

2013

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The Methylation Effect in Medicinal Chemistry

Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile

Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes

Design, Synthesis, and Pharmacological Evaluation of Novel N‑Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors

Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases

New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia

Understanding the Structural Basis of ALDH-2 Inhibition by Molecular Docking

NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives

The Use of Conformational Restriction in Medicinal Chemistry

Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres: A New Class of Potent and Selective Acetylcholinesterase Inhibitors

Microwave-assisted synthesis and structure–activity relationships of neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives

Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties

Structure-property relationship studies of 3-acyl-substituted furans: the serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety

Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

N -acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity

N-Acylhydrazones as drugs

Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs

Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC–MS/MS: Application for a pharmacokinetic study

Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl- N -Acylhydrazone Derivative

Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats

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