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Mechanism of local anesthetic drug action on voltage-gated sodium channels

Current pharmaceutical design, 2005-08, Vol.11 (21), p.2671-2686

2005

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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

Physiological reviews, 1996-07, Vol.76 (3), p.887-926

1996

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Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block

The Journal of physiology, 2002-08, Vol.543 (1), p.71-84

2002

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Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

Molecular biology and evolution, 2008-06, Vol.25 (6), p.1016-1024

2008

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A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

Biophysical journal, 1994, Vol.66 (1), p.1-13

1994

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mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

The Journal of general physiology, 2000-11, Vol.116 (5), p.679-690

2000

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Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells

The Journal of physiology, 1992-08, Vol.454 (1), p.673-688

1992

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Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.14126-14131

1997

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Two phosphatase sites on the Ca2+ channel affecting different kinetic functions

The Journal of physiology, 1993-10, Vol.470 (1), p.73-84

1993

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Mechanism of cAMP-Dependent Modulation of Cardiac Sodium Channel Current Kinetics

Circulation research, 1993-04, Vol.72 (4), p.807-815

1993

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A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

Biophysical journal, 1995-11, Vol.69 (5), p.1657-1665

1995

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A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (5), p.2326-2331

2000

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KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore

Biochemistry (Easton), 2000-07, Vol.39 (28), p.8161-8170

2000

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Adrenergic Modulation of the Transient Outward Current in Isolated Canine Purkinje Cells

Circulation research, 1988-01, Vol.62 (1), p.162-172

1988

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Structural and Gating Changes of the Sodium Channel Induced by Mutation of a Residue in the Upper Third of IVS6, Creating an External Access Path for Local Anesthetics

Molecular pharmacology, 2001-04, Vol.59 (4), p.684-691

2001

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Dose-Dependent Modulation of the Cardiac Sodium Channel by Sea Anemone Toxin ATXII

Circulation research, 1992-02, Vol.70 (2), p.285-301

1992

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Afterdepolarizations and triggered activity

Basic research in cardiology, 1992, Vol.87 Suppl 2, p.105-113

Fozzard, H A

1992

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Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells

Circulation research, 1988-08, Vol.63 (2), p.386-398

1988

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A model of scorpion toxin binding to voltage-gated K+ channels

The Journal of membrane biology, 1997-08, Vol.158 (3), p.187-196

1997

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Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca2+ Channel

Biochemistry (Easton), 2001-06, Vol.40 (23), p.6786-6794

2001

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A Structural Motif for the Voltage-Gated Potassium Channel Pore

Proceedings of the National Academy of Sciences - PNAS, 1995-09, Vol.92 (20), p.9215-9219

1995

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Kinetic analysis of single sodium channels from canine cardiac Purkinje cells

The Journal of general physiology, 1990-03, Vol.95 (3), p.411-437

1990

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Increase in Intracellular Sodium Ion Activity during Stimulation in Mammalian Cardiac Muscle

Circulation research, 1982-05, Vol.50 (5), p.651-662

1982

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Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na + Channel Outer Vestibule

Biophysical journal, 1998-12, Vol.75 (6), p.2647-2657

1998

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Is there a second external lidocaine binding site on mammalian cardiac cells?

American journal of physiology. Heart and circulatory physiology, 1989-07, Vol.257 (1), p.H79-H84

1989

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Mechanism of local anesthetic drug action on voltage-gated sodium channels

Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block

Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells

Sodium Channel Selectivity Filter Regulates Antiarrhythmic Drug Binding

Two phosphatase sites on the Ca2+ channel affecting different kinetic functions

Mechanism of cAMP-Dependent Modulation of Cardiac Sodium Channel Current Kinetics

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

A Critical Residue for Isoform Difference in Tetrodotoxin Affinity Is a Molecular Determinant of the External Access Path for Local Anesthetics in the Cardiac Sodium Channel

KcsA Crystal Structure as Framework for a Molecular Model of the Na+ Channel Pore

Adrenergic Modulation of the Transient Outward Current in Isolated Canine Purkinje Cells

Structural and Gating Changes of the Sodium Channel Induced by Mutation of a Residue in the Upper Third of IVS6, Creating an External Access Path for Local Anesthetics

Dose-Dependent Modulation of the Cardiac Sodium Channel by Sea Anemone Toxin ATXII

Afterdepolarizations and triggered activity

Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells

A model of scorpion toxin binding to voltage-gated K+ channels

Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca2+ Channel

A Structural Motif for the Voltage-Gated Potassium Channel Pore

Kinetic analysis of single sodium channels from canine cardiac Purkinje cells

Increase in Intracellular Sodium Ion Activity during Stimulation in Mammalian Cardiac Muscle

Differences in Saxitoxin and Tetrodotoxin Binding Revealed by Mutagenesis of the Na + Channel Outer Vestibule

Is there a second external lidocaine binding site on mammalian cardiac cells?

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