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Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7472-7479

2012

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Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor

The Journal of pharmacology and experimental therapeutics, 2012-08, Vol.342 (2), p.399

2012

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A role for sensory nerves in the late asthmatic response

Thorax, 2012-01, Vol.67 (1), p.19-25

2012

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The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3675-3684

2010

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MRI of lung parenchyma in rats and mice using a gradient-echo sequence

NMR in biomedicine, 2001-08, Vol.14 (5), p.297-306

2001

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Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI

American journal of physiology. Lung cellular and molecular physiology, 2002-07, Vol.283 (1), p.22-L30

2002

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The case for a role for adenosine in asthma: almost convincing?

Current opinion in pharmacology, 2003-06, Vol.3 (3), p.264-269

Fozard, John R

2003

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An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6280-6285

2012

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An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6280-6285

2012

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Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat

European journal of pharmacology, 2002-03, Vol.438 (3), p.183-188

2002

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Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog

European journal of pharmacology, 2003-08, Vol.475 (1-3), p.79-84

2003

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Progress towards novel adenosine receptor therapeutics gleaned from the recent patent literature

Expert opinion on therapeutic patents, 2010-08, Vol.20 (8), p.987-1005

2010

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Stereoselective Preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a Potent and Orally Active Dual Neurokinin NK1/NK2 Receptor Antagonist

Journal of medicinal chemistry, 2003-07, Vol.46 (16), p.3508-3513

2003

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Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI

American journal of physiology. Lung cellular and molecular physiology, 2007-03, Vol.292 (3), p.L644-L653

2007

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Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

Trends in pharmacological sciences (Regular ed.), 1996-08, Vol.17 (8), p.294-298

1996

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Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Journal of magnetic resonance imaging, 2007-10, Vol.26 (4), p.941-949

2007

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Techniques: Magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs

Trends in pharmacological sciences (Regular ed.), 2003-10, Vol.24 (10), p.550-554

2003

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Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats

Magnetic resonance in medicine, 2006-12, Vol.56 (6), p.1242-1250

2006

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Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat

American journal of physiology. Lung cellular and molecular physiology, 2006-10, Vol.291 (4), p.L651-L657

2006

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The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats

Naunyn-Schmiedeberg's archives of pharmacology, 2005-02, Vol.371 (2), p.158-168

2005

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Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.1219-1224

2010

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Pulmonary Inflammation Monitored Noninvasively by MRI in Freely Breathing Rats

Biochemical and biophysical research communications, 2002-03, Vol.292 (1), p.216-221

2002

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Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice

The Journal of pharmacology and experimental therapeutics, 2001-08, Vol.298 (2), p.433

2001

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Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging

British journal of pharmacology, 2003-09, Vol.140 (2), p.239-246

2003

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Interaction between adenosine and allergen or compound 48/80 on lung parenchymal strips from actively sensitized Brown Norway rats

European journal of pharmacology, 2004-09, Vol.498 (1), p.227-232

2004

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Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate

Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor

A role for sensory nerves in the late asthmatic response

The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist

MRI of lung parenchyma in rats and mice using a gradient-echo sequence

Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI

The case for a role for adenosine in asthma: almost convincing?

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol

An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat

Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog

Progress towards novel adenosine receptor therapeutics gleaned from the recent patent literature

Stereoselective Preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a Potent and Orally Active Dual Neurokinin NK1/NK2 Receptor Antagonist

Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Techniques: Magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs

Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats

Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat

The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats

Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists

Pulmonary Inflammation Monitored Noninvasively by MRI in Freely Breathing Rats

Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice

Resolution of the oedema associated with allergic pulmonary inflammation in rats assessed noninvasively by magnetic resonance imaging

Interaction between adenosine and allergen or compound 48/80 on lung parenchymal strips from actively sensitized Brown Norway rats

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