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Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Oncotarget, 2016-12, Vol.7 (50), p.83208-83222

2016

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Glucosylceramide synthase maintains influenza virus entry and infection

PloS one, 2020-02, Vol.15 (2), p.e0228735-e0228735

2020

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Nervonic acid limits weight gain in a mouse model of diet‐induced obesity

The FASEB journal, 2020-11, Vol.34 (11), p.15314-15326

2020

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TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth

Genes & development, 2019-04, Vol.33 (7-8), p.388-402

2019

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Dysregulation of sphingolipid metabolism in cancer

Cancer biology & therapy, 2011-01, Vol.11 (2), p.138-149

2011

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Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Journal of lipid research, 2019-06, Vol.60 (6), p.1078-1086

2019

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Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Autophagy, 2011-01, Vol.7 (1), p.61-73

2011

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Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.721-728

2018

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Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Cell reports (Cambridge), 2016-11, Vol.17 (6), p.1532-1545

2016

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Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

Biological chemistry, 2015-06, Vol.396 (6-7), p.737

2015

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Circulating sphingolipid biomarkers in models of type 1 diabetes

Journal of lipid research, 2011-03, Vol.52 (3), p.509-517

2011

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Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Journal of lipid research, 2019-09, Vol.60 (9), p.1590-1602

2019

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Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

Biochimica et biophysica acta, 2013-12, Vol.1831 (12), p.1657-1664

2013

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Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

American Journal of Physiology: Cell Physiology, 2010-08, Vol.299 (2), p.C335-C344

2010

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Ceramide 1-Phosphate Mediates Endothelial Cell Invasion via the Annexin a2-p11 Heterotetrameric Protein Complex

The Journal of biological chemistry, 2013-07, Vol.288 (27), p.19726-19738

2013

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Ceramide Nanoliposomes as Potential Therapeutic Reagents for Asthma

Cells (Basel, Switzerland), 2023-02, Vol.12 (4), p.591

2023

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Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels[S]

Journal of lipid research, 2010-03, Vol.51 (3), p.641-651

2010

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Pronecroptotic Therapy Using Ceramide Nanoliposomes Is Effective for Triple-Negative Breast Cancer Cells

Cells (Basel, Switzerland), 2024-02, Vol.13 (5), p.405

2024

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Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Cancers, 2023-12, Vol.15 (24), p.5866

2023

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Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia—Impact on enzyme activity and response to cytotoxics

Biochimica et biophysica acta, 2015-07, Vol.1851 (7), p.919-928

2015

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Tricarboxylic acid (TCA) cycle, sphingolipid, and phosphatidylcholine metabolism are dysregulated in T. gondii infection-induced cachexia

Heliyon, 2023-07, Vol.9 (7), p.e17411-e17411, Article e17411

2023

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C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

PloS one, 2013-12, Vol.8 (12), p.e84648

2013

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A MicroRNA93–Interferon Regulatory Factor-9–Immunoresponsive Gene-1–Itaconic Acid Pathway Modulates M2-Like Macrophage Polarization to Revascularize Ischemic Muscle

Circulation (New York, N.Y.), 2017-06, Vol.135 (24), p.2403-2425

2017

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Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer

Cancer biology & therapy, 2011-10, Vol.12 (7), p.574-585

2011

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Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Glucosylceramide synthase maintains influenza virus entry and infection

Nervonic acid limits weight gain in a mouse model of diet‐induced obesity

TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth

Dysregulation of sphingolipid metabolism in cancer

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

Circulating sphingolipid biomarkers in models of type 1 diabetes

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

Ceramide 1-Phosphate Mediates Endothelial Cell Invasion via the Annexin a2-p11 Heterotetrameric Protein Complex

Ceramide Nanoliposomes as Potential Therapeutic Reagents for Asthma

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels[S]

Pronecroptotic Therapy Using Ceramide Nanoliposomes Is Effective for Triple-Negative Breast Cancer Cells

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia—Impact on enzyme activity and response to cytotoxics

Tricarboxylic acid (TCA) cycle, sphingolipid, and phosphatidylcholine metabolism are dysregulated in T. gondii infection-induced cachexia

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia

A MicroRNA93–Interferon Regulatory Factor-9–Immunoresponsive Gene-1–Itaconic Acid Pathway Modulates M2-Like Macrophage Polarization to Revascularize Ischemic Muscle

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer

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