UB Paderborn / Katalog / Suche / in CDI

Targeting the Th17 pathway in psoriasis

Journal of leukocyte biology, 2012-12, Vol.92 (6), p.1187-1197

2012

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The mode of action of IL-23 in experimental inflammatory arthritic pain and disease

Arthritis research & therapy, 2024-08, Vol.26 (1), p.148-13, Article 148

2024

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Nature, 2005-03, Vol.434 (7033), p.648-652

2005

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Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Scientific reports, 2021-05, Vol.11 (1), p.11066-14, Article 11066

2021

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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans

Scientific reports, 2024-07, Vol.14 (1), p.17515-12, Article 17515

2024

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Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells

The Journal of immunology (1950), 2006-09, Vol.177 (5), p.3439-3447

2006

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Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Scientific reports, 2022-04, Vol.12 (1), p.5740-5740, Article 5740

2022

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Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.30469-30477

2003

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Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

Journal of allergy and clinical immunology, 2021-06, Vol.147 (6), p.2370-2380

2021

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Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1154

2007

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IL-23 regulation of myeloid cell biology during inflammation

Cytokine (Philadelphia, Pa.), 2024-07, Vol.179, p.156619-156619, Article 156619

2024

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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

Scientific reports, 2016-12, Vol.6 (1), p.37977, Article 37977

2016

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Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.811-815

2013

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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127205-127205, Article 127205

2020

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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127174-127174, Article 127174

2020

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Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2047-2057

2017

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6-Substituted quinolines as RORγt inverse agonists

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5277-5283

2017

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3-Substituted Quinolines as RORγt Inverse Agonists

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (12), p.1463-1470

2019

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Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness

American journal of respiratory and critical care medicine, 2010-05, Vol.181 (9), p.899-907

2010

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Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

American journal of respiratory and critical care medicine, 2010-05, Vol.181 (9), p.899-907

2010

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Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.811-815

2013

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Azabenzthiazole inhibitors of leukotriene A4 hydrolase

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7504-7511

2012

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Impaired Immunoproteasome Assembly and Immune Responses in PA28$^{-/-}$ Mice

Science (American Association for the Advancement of Science), 1999-12, Vol.286 (5447), p.2162-2165

1999

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Su1738 JNJ-77242113, AN ORAL PEPTIDE SELECTIVELY TARGETING THE IL-23 RECEPTOR, DEMONSTRATES PHARMACODYNAMIC ACTIVITY IN RAT AND HUMAN COLON TISSUE EXPLANTS FOLLOWING ORAL DOSING

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-791-S-792

2024

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Su1743 GUSELKUMAB BINDING TO CD64+ IL-23–PRODUCING MYELOID CELLS ENHANCES POTENCY FOR NEUTRALIZING IL-23 SIGNALING

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-793-S-793

2024

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Targeting the Th17 pathway in psoriasis

The mode of action of IL-23 in experimental inflammatory arthritic pain and disease

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans

Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells

Author Correction: Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534

Catalytic Activity of ADAM8, ADAM15, and MDC-L (ADAM28) on Synthetic Peptide Substrates and in Ectodomain Cleavage of CD23

Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton

IL-23 regulation of myeloid cell biology during inflammation

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt

6-Substituted quinolines as RORγt inverse agonists

3-Substituted Quinolines as RORγt Inverse Agonists

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness

Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase

Azabenzthiazole inhibitors of leukotriene A4 hydrolase

Impaired Immunoproteasome Assembly and Immune Responses in PA28$^{-/-}$ Mice

Su1738 JNJ-77242113, AN ORAL PEPTIDE SELECTIVELY TARGETING THE IL-23 RECEPTOR, DEMONSTRATES PHARMACODYNAMIC ACTIVITY IN RAT AND HUMAN COLON TISSUE EXPLANTS FOLLOWING ORAL DOSING

Su1743 GUSELKUMAB BINDING TO CD64+ IL-23–PRODUCING MYELOID CELLS ENHANCES POTENCY FOR NEUTRALIZING IL-23 SIGNALING

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