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Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics

Scientific reports, 2024-05, Vol.14 (1), p.10360-10360, Article 10360

2024

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Dual-target ligand discovery for Alzheimer's disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2166040-2166040

2023

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Commiphora myrrha acute toxicity

Clinical toxicology (Philadelphia, Pa.), 2024-02, Vol.62 (2), p.135-136

2024

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Design, synthesis and biological evaluation of novel α-aminophosphonate oxadiazoles via optimized iron triflate catalyzed reaction as apoptotic inducers

European journal of medicinal chemistry, 2019-10, Vol.180, p.310-320

2019

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Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

BMC chemistry, 2022-12, Vol.16 (1), p.114-114, Article 114

2022

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Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates

European journal of medicinal chemistry, 2024-10, Vol.276, p.116679, Article 116679

2024

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The antagonistic potential of Trichoderma harzianum against barley leaf-stripe disease

Novel research in microbiology journal, 2024-04, Vol.8 (2), p.2393-2413

2024

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Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers

European journal of medicinal chemistry, 2016-04, Vol.112, p.48-59

2016

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Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors

European journal of medicinal chemistry, 2023-12, Vol.261, p.115805-115805, Article 115805

2023

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Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II

European journal of medicinal chemistry, 2024-05, Vol.271, p.116434-116434, Article 116434

2024

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Correlating physico-chemical properties of analytes with Hansen solubility parameters of solvents using machine learning algorithm for predicting suitable extraction solvent

Scientific reports, 2024-08, Vol.14 (1), p.18741-9, Article 18741

2024

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LC–MS/MS bioassay of four proton pump inhibitors

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-02, Vol.1076, p.61-69

2018

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QSRR modeling for the chromatographic retention behavior of some β-lactam antibiotics using forward and firefly variable selection algorithms coupled with multiple linear regression

Journal of Chromatography A, 2018-05, Vol.1549, p.51-62

2018

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Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors

Drug development research, 2022-09, Vol.83 (6), p.1281-1291

2022

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Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking

Molecules (Basel, Switzerland), 2022-08, Vol.27 (17), p.5501

2022

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Synthesis and Evaluation of Thioamide and Bromo Derivatives of 1,3-Diphenylpropane-1,3-dione as 5α-Reductase Inhibitors

Current organic synthesis, 2023-06, Vol.20

2023

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Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors

Medicinal chemistry research, 2021-05, Vol.30 (5), p.1125-1138

2021

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Lead generation of cysteine based mesenchymal epithelial transition (c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation

Computers in biology and medicine, 2022-07, Vol.146, p.105526-105526, Article 105526

2022

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Synthesis, biological evaluation and molecular docking of new sulfonamide-based indolinone derivatives as multitargeted kinase inhibitors against leukemia

Bioorganic chemistry, 2021-12, Vol.117, p.105421-105421, Article 105421

2021

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Association of interleukin-36α gene expression in Egyptian patients with systemic lupus erythematosus with organ involvement and disease activity

The Egyptian journal of immunology, 2021-04, Vol.28 (2), p.75-84

2021

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Screening and optimization of samarium-assisted complexation for the determination of norfloxacin, levofloxacin and lomefloxacin in their corresponding dosage forms employing spectrofluorimetry

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2019-01, Vol.206, p.578-587

2019

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Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma

Bioorganic chemistry, 2021-07, Vol.112, p.104985-104985, Article 104985

2021

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Novel sulfonamide‐phosphonate conjugates as carbonic anhydrase isozymes inhibitors

Drug development research, 2024-02, Vol.85 (1), p.e22135-n/a

2024

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Development of a reversed phase liquid chromatographic method for analysis of pyridoxal‐5′‐phosphate and its impurities

Electrophoresis, 2018-10, Vol.39 (20), p.2540-2549

2018

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Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors

Drug development research, 2022-04, Vol.83 (2), p.485-500

2022

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Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics

Dual-target ligand discovery for Alzheimer's disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

Commiphora myrrha acute toxicity

Design, synthesis and biological evaluation of novel α-aminophosphonate oxadiazoles via optimized iron triflate catalyzed reaction as apoptotic inducers

Application of Box-Behnken experimental design and response surface methodology for selecting the optimum RP-HPLC conditions for the simultaneous determination of methocarbamol, indomethacin and betamethasone in their pharmaceutical dosage form

Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates

The antagonistic potential of Trichoderma harzianum against barley leaf-stripe disease

Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers

Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors

Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II

Correlating physico-chemical properties of analytes with Hansen solubility parameters of solvents using machine learning algorithm for predicting suitable extraction solvent

LC–MS/MS bioassay of four proton pump inhibitors

QSRR modeling for the chromatographic retention behavior of some β-lactam antibiotics using forward and firefly variable selection algorithms coupled with multiple linear regression

Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors

Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking

Synthesis and Evaluation of Thioamide and Bromo Derivatives of 1,3-Diphenylpropane-1,3-dione as 5α-Reductase Inhibitors

Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors

Lead generation of cysteine based mesenchymal epithelial transition (c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation

Synthesis, biological evaluation and molecular docking of new sulfonamide-based indolinone derivatives as multitargeted kinase inhibitors against leukemia

Association of interleukin-36α gene expression in Egyptian patients with systemic lupus erythematosus with organ involvement and disease activity

Screening and optimization of samarium-assisted complexation for the determination of norfloxacin, levofloxacin and lomefloxacin in their corresponding dosage forms employing spectrofluorimetry

Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma

Novel sulfonamide‐phosphonate conjugates as carbonic anhydrase isozymes inhibitors

Development of a reversed phase liquid chromatographic method for analysis of pyridoxal‐5′‐phosphate and its impurities

Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors

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