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The impact of drug-induced QT interval prolongation on drug discovery and development

Nature reviews. Drug discovery, 2003-06, Vol.2 (6), p.439-447

2003

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Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects

The American heart journal, 2012-06, Vol.163 (6), p.912-930

2012

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Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

The Journal of pharmacology and experimental therapeutics, 2005-01, Vol.312 (1), p.1

2005

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Beat‐to‐beat ECG restitution: A review and proposal for a new biomarker to assess cardiac stress and ventricular tachyarrhythmia vulnerability

Annals of noninvasive electrocardiology, 2017-09, Vol.22 (5), p.n/a

Fossa, Anthony A.

2017

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QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

The Journal of pharmacology and experimental therapeutics, 2006-02, Vol.316 (2), p.498

2006

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Comparison of Two Highly Automated ECG Algorithms for Detection of Drug‐Induced Cardiac Ion Channel Block

Clinical pharmacology and therapeutics, 2018-08, Vol.104 (2), p.356-363

2018

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Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability

The Journal of pharmacology and experimental therapeutics, 2006-07, Vol.318 (1), p.352

2006

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Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig

European journal of pharmacology, 2004-02, Vol.486 (2), p.209-221

2004

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The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment

The Journal of pharmacology and experimental therapeutics, 2002-08, Vol.302 (2), p.828

2002

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Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method

Pharmacology & therapeutics (Oxford), 2008-08, Vol.119 (2), p.133-140

Fossa, Anthony A

2008

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Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method

Pharmacology & therapeutics (Oxford), 2008-05, Vol.118 (2), p.231-238

Fossa, Anthony A

2008

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Use of ECG Restitution (Beat-to-Beat QT-TQ Interval Analysis) to Assess Arrhythmogenic Risk of QTc Prolongation with Guanfacine

Annals of noninvasive electrocardiology, 2014-11, Vol.19 (6), p.582-594

2014

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Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig

The American journal of tropical medicine and hygiene, 2007-11, Vol.77 (5), p.929

2007

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Transmural Dispersion of Repolarization as a Preclinical Marker of Drug-induced Proarrhythmia

Journal of cardiovascular pharmacology, 2012-08, Vol.60 (2), p.165-171

2012

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Use of Continuous ECG for Improvements in Assessing the Standing Response as a Positive Control for QT Prolongation

Annals of noninvasive electrocardiology, 2014-01, Vol.19 (1), p.82-89

2014

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Assessing QT prolongation and electrocardiography restitution using a beat-to-beat method

Cardiology journal, 2010, Vol.17 (3), p.230-243

2010

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Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine

Toxicology and applied pharmacology, 2012-11, Vol.264 (3), p.343-350

2012

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Improving the precision of QT measurements

Cardiology journal, 2011, Vol.18 (4), p.401-410

2011

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Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants

Journal of pharmacological and toxicological methods, 2007-01, Vol.55 (1), p.78-85

2007

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Analyses of Dynamic Beat-to-Beat QT-TQ Interval (ECG Restitution) Changes in Humans under Normal Sinus Rhythm and Prior to an Event of Torsades de Pointes during QT Prolongation Caused by Sotalol

Annals of noninvasive electrocardiology, 2007-10, Vol.12 (4), p.338-348

2007

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Points to consider emerging from a mini-workshop on cardiac safety: Assessing torsades de pointes liability

Journal of pharmacological and toxicological methods, 2007-09, Vol.56 (2), p.91-94

2007

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Statistical analysis of QT interval as a function of changes in RR interval in the conscious dog

Journal of pharmacological and toxicological methods, 2001-07, Vol.46 (1), p.1-11

2001

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Cardiovascular effects of cholecystokinin-4 are mediated by the cholecystokinin-B receptor subtype in the conscious guinea pig and dog

The Journal of pharmacology and experimental therapeutics, 1997-04, Vol.281 (1), p.180

1997

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Zoniporide: A Potent and Selective Inhibitor of the Human Sodium‐Hydrogen Exchanger Isoform 1 (NHE‐1)

Cardiovascular drug reviews, 2003-03, Vol.21 (1), p.17-32

2003

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Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril

Journal of cardiovascular pharmacology, 1992-07, Vol.20 (1), p.75-82

1992

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The impact of drug-induced QT interval prolongation on drug discovery and development

Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects

Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition

Beat‐to‐beat ECG restitution: A review and proposal for a new biomarker to assess cardiac stress and ventricular tachyarrhythmia vulnerability

QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

Comparison of Two Highly Automated ECG Algorithms for Detection of Drug‐Induced Cardiac Ion Channel Block

Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability

Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig

The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment

Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method

Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method

Use of ECG Restitution (Beat-to-Beat QT-TQ Interval Analysis) to Assess Arrhythmogenic Risk of QTc Prolongation with Guanfacine

Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig

Transmural Dispersion of Repolarization as a Preclinical Marker of Drug-induced Proarrhythmia

Use of Continuous ECG for Improvements in Assessing the Standing Response as a Positive Control for QT Prolongation

Assessing QT prolongation and electrocardiography restitution using a beat-to-beat method

Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine

Improving the precision of QT measurements

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants

Analyses of Dynamic Beat-to-Beat QT-TQ Interval (ECG Restitution) Changes in Humans under Normal Sinus Rhythm and Prior to an Event of Torsades de Pointes during QT Prolongation Caused by Sotalol

Points to consider emerging from a mini-workshop on cardiac safety: Assessing torsades de pointes liability

Statistical analysis of QT interval as a function of changes in RR interval in the conscious dog

Cardiovascular effects of cholecystokinin-4 are mediated by the cholecystokinin-B receptor subtype in the conscious guinea pig and dog

Zoniporide: A Potent and Selective Inhibitor of the Human Sodium‐Hydrogen Exchanger Isoform 1 (NHE‐1)

Synergistic Effect on Reduction in Blood Pressure with Coadministration of the Renin Inhibitor, CP-80,794, and the Angiotensin Converting Enzyme Inhibitor, Captopril

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