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ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors

Osteoarthritis and cartilage, 2015-08, Vol.23 (8), p.1231-1232

Fosang, A.J

2015

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Identifying the human aggrecanase

Osteoarthritis and cartilage, 2010-09, Vol.18 (9), p.1109-1116

2010

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PPARdelta promotes the progression of post-traumatic osteoarthritis

Osteoarthritis and cartilage, 2015-04, Vol.23, p.A307-A307

2015

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Effect of aggrecanase and collagenase resistant knock-in, age and joint-overuse on murine cartilage

Osteoarthritis and cartilage, 2015-04, Vol.23, p.A107-A107

2015

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A 32-mer fragment of aggrecan promotes knee hyperalgesia in the DMM model of osteoarthritis through direct nociceptor activation via TLR2

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S452-S452

2016

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Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan

FEBS letters, 2005-09, Vol.579 (22), p.5019-5023

2005

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Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S30-S30

2012

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An aggrecan 32-mer fragment generated in osteoarthritis directly excites nociceptive neurons

Osteoarthritis and cartilage, 2015-04, Vol.23, p.A41-A42

2015

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Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice

Osteoarthritis and cartilage, 2013-02, Vol.21 (2), p.401-404

2013

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Aggrecan fragments in the synovial fluid of osteoarthritis and juvenile idiopathic arthritis patients reveals differences in the specificity of aggrecanase cleavage in the interglobular domain, but not in the chondroitin-sulphate-rich region

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S117-S117

2012

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Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S12-S12

2014

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The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B

The Journal of biological chemistry, 1992-09, Vol.267 (27), p.19470-19474

1992

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Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

Matrix biology, 2019-10, Vol.83, p.77-96

2019

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206 CARTILAGE DEGRADATION IS FULLY REVERSIBLE IN THE PRESENCE OF AGGRECANASE BUT NOT MATRIX METALLOPROTEINASE ACTIVITY

Osteoarthritis and cartilage, 2007, Vol.15, p.C120-C120

2007

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Erratum to “MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays” [Osteoarthritis Cartilage 15 (2007) 212–21]

Osteoarthritis and cartilage, 2007-05, Vol.15 (5), p.594-595

2007

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Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre ; ROSA26R LacZ reporter mice

Osteoarthritis and cartilage, 2012, Vol.21 (2), p.401-404

2012

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Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan

Matrix biology, 2009, Vol.28 (1), p.53-61

2009

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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

Osteoarthritis and cartilage, 2006-04, Vol.14 (4), p.392-402

2006

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Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

The Journal of biological chemistry, 1991-08, Vol.266 (24), p.15579-15582

1991

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Pregnancy-related changes in the connective tissue of the ovine cervix

Biology of reproduction, 1984-06, Vol.30 (5), p.1223-1235

1984

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ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors

Identifying the human aggrecanase

PPARdelta promotes the progression of post-traumatic osteoarthritis

Effect of aggrecanase and collagenase resistant knock-in, age and joint-overuse on murine cartilage

A 32-mer fragment of aggrecan promotes knee hyperalgesia in the DMM model of osteoarthritis through direct nociceptor activation via TLR2

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan

Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo

An aggrecan 32-mer fragment generated in osteoarthritis directly excites nociceptive neurons

Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice

Aggrecan fragments in the synovial fluid of osteoarthritis and juvenile idiopathic arthritis patients reveals differences in the specificity of aggrecanase cleavage in the interglobular domain, but not in the chondroitin-sulphate-rich region

Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs

206 CARTILAGE DEGRADATION IS FULLY REVERSIBLE IN THE PRESENCE OF AGGRECANASE BUT NOT MATRIX METALLOPROTEINASE ACTIVITY

Erratum to “MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays” [Osteoarthritis Cartilage 15 (2007) 212–21]

Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre ; ROSA26R LacZ reporter mice

Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan

ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins

Pregnancy-related changes in the connective tissue of the ovine cervix

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