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Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2

The Journal of pharmacology and experimental therapeutics, 2001-02, Vol.296 (2), p.558

2001

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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

British journal of pharmacology, 1997-05, Vol.121 (1), p.105-117

1997

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The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (13), p.1773-1778

1999

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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.551

1999

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Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach

The Journal of pharmacology and experimental therapeutics, 1995-09, Vol.274 (3), p.1531

1995

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Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist

Canadian journal of physiology and pharmacology, 1995-02, Vol.73 (2), p.191

1995

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Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist

Canadian journal of physiology and pharmacology, 1989-01, Vol.67 (1), p.17

1989

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Characterization of the recombinant human prostanoid DP receptor and identification of L‐644,698, a novel selective DP agonist

British journal of pharmacology, 1998-04, Vol.123 (7), p.1317-1324

1998

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Increased urinary leukotriene excretion in patients with cardiac ischemia : in vivo evidence for 5-lipoxygenase activation

Circulation (New York, N.Y.), 1992, Vol.85 (1), p.230-236

1992

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Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects

The European respiratory journal, 1994-05, Vol.7 (5), p.907-913

1994

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5-Lipoxygenase

Annual review of biochemistry, 1994-01, Vol.63 (1), p.383-417

1994

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Effect of altitude on urinary leukotriene (LT) E4 excretion and airway responsiveness to histamine in children with atopic asthma

The European respiratory journal, 1995-03, Vol.8 (3), p.357-363

1995

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The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation

Annual review of immunology, 1984-04, Vol.2 (1), p.335-357

1984

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Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2841-2845

1990

Volltextzugriff (PDF)

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Canadian journal of physiology and pharmacology, 1989-05, Vol.67 (5), p.456

1989

Volltextzugriff (PDF)

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

Nature (London), 1980-07, Vol.286 (5770), p.264-265

1980

Volltextzugriff (PDF)

Innovations in drug research: inhibitors of thromboxane and leukotrienes

Clinical and experimental allergy, 1991-05, Vol.21 (s1), p.272-276

Ford-Hutchinson, A. W.

1991

Volltextzugriff (PDF)

Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells

The Journal of immunology (1950), 1994-07, Vol.153 (2), p.776

1994

Volltextzugriff (PDF)

BQ-153, a novel endothelin (ET)A antagonist, attenuates the renal vascular effects of endothelin-1

Journal of pharmacy and pharmacology, 1992-09, Vol.44 (9), p.782-785

1992

Volltextzugriff (PDF)

A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor

European journal of pharmacology, 1999-07, Vol.377 (1), p.101-115

1999

Volltextzugriff (PDF)

Leukotriene B4 in inflammation

Critical reviews in immunology, 1990, Vol.10 (1), p.1

Ford-Hutchinson, A W

1990

Volltextzugriff (PDF)

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

Canadian journal of physiology and pharmacology, 1992-06, Vol.70 (6), p.799

1992

Volltextzugriff (PDF)

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes

The Journal of biological chemistry, 1990-01, Vol.265 (3), p.1436-1442

1990

Volltextzugriff (PDF)

Contractile activity of calcitonin gene-related peptide on pulmonary tissues

Journal of pharmacy and pharmacology, 1988-03, Vol.40 (3), p.210-211

1988

Volltextzugriff (PDF)

The human prostanoid DP receptor stimulates mucin secretion in LS174T cells

British journal of pharmacology, 2000-12, Vol.131 (8), p.1537-1545

2000

Volltextzugriff (PDF)

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Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach

Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist

Characterization of the recombinant human prostanoid DP receptor and identification of L‐644,698, a novel selective DP agonist

Increased urinary leukotriene excretion in patients with cardiac ischemia : in vivo evidence for 5-lipoxygenase activation

Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects

5-Lipoxygenase

Effect of altitude on urinary leukotriene (LT) E4 excretion and airway responsiveness to histamine in children with atopic asthma

The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation

Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

Innovations in drug research: inhibitors of thromboxane and leukotrienes

Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells

BQ-153, a novel endothelin (ET)A antagonist, attenuates the renal vascular effects of endothelin-1

A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor

Leukotriene B4 in inflammation

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes

Contractile activity of calcitonin gene-related peptide on pulmonary tissues

The human prostanoid DP receptor stimulates mucin secretion in LS174T cells

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