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P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

The Lancet (British edition), 2015-03, Vol.385 (9974), p.1198-1205

2015

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Action of MK‐7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation

British journal of pharmacology, 2019-07, Vol.176 (13), p.2279-2291

2019

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Purinergic receptors in the carotid body as a new drug target for controlling hypertension

Nature medicine, 2016-10, Vol.22 (10), p.1151-1159

2016

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Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

Journal of allergy and clinical immunology, 2016-07, Vol.138 (1), p.249-261.e12

2016

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In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

Purinergic signalling, 2012-02, Vol.8 (Suppl 1), p.3-26

Ford, Anthony P.

2012

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P2X3 receptor antagonism attenuates the progression of heart failure

Nature communications, 2023-03, Vol.14 (1), p.1725-1725, Article 1725

2023

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The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders

Frontiers in cellular neuroscience, 2013-12, Vol.7, p.267-267

2013

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Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway

PloS one, 2015-01, Vol.10 (1), p.e0115701-e0115701

2015

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Purinoceptors as therapeutic targets for lower urinary tract dysfunction

British journal of pharmacology, 2006-02, Vol.147 (S2), p.S132-S143

2006

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Pivotal Role of Nucleotide P2X2 Receptor Subunit of the ATP-Gated Ion Channel Mediating Ventilatory Responses to Hypoxia

The Journal of neuroscience, 2003-12, Vol.23 (36), p.11315-11321

2003

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Modulation of bladder afferent signals in normal and spinal cord‐injured rats by purinergic P2X3 and P2X2/3 receptors

BJU international, 2012-10, Vol.110 (8b), p.E409-E414

2012

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Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

American journal of physiology. Regulatory, integrative and comparative physiology, 2010-03, Vol.298 (3), p.R534-R547

2010

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P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

The Journal of physiology, 2005-09, Vol.567 (2), p.621-639

2005

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The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study

The European respiratory journal, 2019-07, Vol.54 (1), p.1900439

2019

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Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

The Journal of physiology, 2005-02, Vol.562 (3), p.859-871

2005

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Expression and function of rat urothelial P2Y receptors

American journal of physiology. Renal physiology, 2008-04, Vol.294 (4), p.F821-F829

2008

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Gefapixant in two randomised dose-escalation studies in chronic cough

The European respiratory journal, 2020-03, Vol.55 (3), p.1901615

2020

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P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine

The Journal of physiology, 2003-11, Vol.552 (3), p.809-821

2003

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Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

The lancet respiratory medicine, 2020-08, Vol.8 (8), p.775-785

2020

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Postsynaptic P2X3‐containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice

The Journal of physiology, 2015-03, Vol.593 (5), p.1113-1125

2015

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Selective Pharmacological Blockade of the TRPV1 Receptor Suppresses Sensory Reflexes of the Rodent Bladder

The Journal of urology, 2009-08, Vol.182 (2), p.776-785

2009

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Single- and Multiple-Dose Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist, in Healthy Adults

Journal of clinical pharmacology, 2024-04

2024

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Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

Brain (London, England : 1878), 2010-09, Vol.133 (9), p.2549-2564

2010

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AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

British journal of pharmacology, 2010-07, Vol.160 (6), p.1387-1398

2010

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The inevitability of ATP as a transmitter in the carotid body

Autonomic neuroscience, 2021-09, Vol.234, p.102815-102815, Article 102815

2021

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P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

Action of MK‐7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation

Purinergic receptors in the carotid body as a new drug target for controlling hypertension

Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization

P2X3 receptor antagonism attenuates the progression of heart failure

The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders

Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway

Purinoceptors as therapeutic targets for lower urinary tract dysfunction

Pivotal Role of Nucleotide P2X2 Receptor Subunit of the ATP-Gated Ion Channel Mediating Ventilatory Responses to Hypoxia

Modulation of bladder afferent signals in normal and spinal cord‐injured rats by purinergic P2X3 and P2X2/3 receptors

Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study

Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium

Expression and function of rat urothelial P2Y receptors

Gefapixant in two randomised dose-escalation studies in chronic cough

P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

Postsynaptic P2X3‐containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice

Selective Pharmacological Blockade of the TRPV1 Receptor Suppresses Sensory Reflexes of the Rodent Bladder

Single- and Multiple-Dose Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist, in Healthy Adults

Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats

AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

The inevitability of ATP as a transmitter in the carotid body

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