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A road map for prioritizing warheads for cysteine targeting covalent inhibitors

European journal of medicinal chemistry, 2018-12, Vol.160, p.94-107

2018

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Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis

PloS one, 2015-09, Vol.10 (9), p.e0137217-e0137217

2015

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The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function

Frontiers in immunology, 2021-07, Vol.12, p.680279-680279

2021

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Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

The Journal of biological chemistry, 2013-01, Vol.288 (4), p.2201-2209

2013

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Profilin 1 as a target for cathepsin X activity in tumor cells

PloS one, 2013-01, Vol.8 (1), p.e53918-e53918

2013

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Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer

Seminars in cancer biology, 2015-04, Vol.31, p.76-83

2015

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Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy

Cellular and molecular life sciences : CMLS, 2022-01, Vol.79 (1), p.34-34, Article 34

2022

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Cysteine cathepsins L and X differentially modulate interactions between myeloid-derived suppressor cells and tumor cells

Cancer Immunology, Immunotherapy, 2020-09, Vol.69 (9), p.1869-1880

2020

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The Carboxypeptidase Activity of Cathepsin X is not Controlled by Endogenous Inhibitors

Acta chimica Slovenica, 2019-02, Vol.66 (1), p.58-61

2019

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Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

The international journal of biochemistry & cell biology, 2009-08, Vol.41 (8-9), p.1685-1696

2009

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The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells

Toxicology in vitro, 2022-03, Vol.79, p.105275-105275, Article 105275

2022

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Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

Biological chemistry, 2013-10, Vol.394 (10), p.1349-1352

2013

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Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells

European journal of cell biology, 2017-09, Vol.96 (6), p.622-631

2017

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Lysosomal peptidases in innate immune cells: implications for cancer immunity

Cancer Immunology, Immunotherapy, 2020-02, Vol.69 (2), p.275-283

2020

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Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X

European journal of medicinal chemistry, 2020-05, Vol.193, p.112218-112218, Article 112218

2020

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The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

PLoS pathogens, 2020-11, Vol.16 (11), p.e1009013-e1009013

2020

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Effects of tyrosine kinase inhibitors on androgen, estrogen α, glucocorticoid and thyroid receptors

Toxicology and applied pharmacology, 2022-01, Vol.434, p.115818, Article 115818

2022

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Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1784

2022

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Compensational role between cathepsins

Biochimie, 2024-11, Vol.226, p.62-76

2024

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Cathepsin X cleaves the β2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and α-actinin-1 binding

European journal of immunology, 2009-11, Vol.39 (11), p.3217-3227

2009

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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

Nature chemical biology, 2008-03, Vol.4 (3), p.203-213

2008

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Three‐dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes

European journal of immunology, 2012-12, Vol.42 (12), p.3429-3441

2012

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Kinetic mechanism of Enterococcus faeciumd-aspartate ligase

Biochimie, 2019-03, Vol.158, p.217-223

2019

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Kinetic mechanism of Enterococcus faecium d-aspartate ligase

Biochimie, 2019-03, Vol.158, p.217-223

2019

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Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients

Journal of Atherosclerosis and Thrombosis, 2014/08/26, Vol.21(8), pp.868-877

2014

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A road map for prioritizing warheads for cysteine targeting covalent inhibitors

Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis

The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function

Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells

Profilin 1 as a target for cathepsin X activity in tumor cells

Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer

Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy

Cysteine cathepsins L and X differentially modulate interactions between myeloid-derived suppressor cells and tumor cells

The Carboxypeptidase Activity of Cathepsin X is not Controlled by Endogenous Inhibitors

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

The effect of endocrine disrupting chemicals on the vitronectin-receptor (integrin αvβ3)-mediated cell adhesion of human umbilical vein endothelial cells

Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells

Lysosomal peptidases in innate immune cells: implications for cancer immunity

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

Effects of tyrosine kinase inhibitors on androgen, estrogen α, glucocorticoid and thyroid receptors

Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors

Compensational role between cathepsins

Cathepsin X cleaves the β2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and α-actinin-1 binding

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

Three‐dimensional invasion of macrophages is mediated by cysteine cathepsins in protrusive podosomes

Kinetic mechanism of Enterococcus faeciumd-aspartate ligase

Kinetic mechanism of Enterococcus faecium d-aspartate ligase

Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients

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