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The Expanding Therapeutic Utility of Botulinum Neurotoxins

Toxins, 2018-05, Vol.10 (5), p.208

2018

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Replacement of the Mouse LD50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Toxins, 2023-04, Vol.15 (5), p.314

2023

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hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

Frontiers in pharmacology, 2021-01, Vol.11, p.617867

2021

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Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity

Toxins, 2018-07, Vol.10 (7), p.278

2018

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Tissue Distribution Profiles of the Human TRPM Cation Channel Family

Journal of receptors and signal transduction, 2006, Vol.26 (3), p.159-178

2006

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A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

Pharmacology research & perspectives, 2018-12, Vol.6 (6), p.e00446-n/a

2018

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Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4951-4954

2010

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Development of a cell-based assay to replace LD50 for botulinum toxin A1

Toxicon (Oxford), 2018-12, Vol.156, p.S34-S34

2018

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Replacement of the Mouse LD[sub.50] Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Toxins, 2023-04, Vol.15 (5)

2023

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TRPM2 Is Elevated in the tMCAO Stroke Model, Transcriptionally Regulated, and Functionally Expressed in C13 Microglia

Journal of receptors and signal transduction, 2006, Vol.26 (3), p.179-198

2006

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Use of high-content imaging in botulinum toxin research

Toxicon (Oxford), 2016-12, Vol.123, p.S29-S29

2016

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Translational value of hiPSC-derived models for botulinum neurotoxin research

Toxicon (Oxford), 2018-12, Vol.156, p.S84-S85

2018

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Replacement of the Mouse LD 50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Toxins, 2023-04, Vol.15 (5)

2023

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105. Effect of botulinum neurotoxin type A subtypes on guinea pig isolated ileum smooth muscle

Toxicon (Oxford), 2015-01, Vol.93, p.S32-S32

2015

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Potency comparison in in vitro, ex vivo, and in vivo assays of commercially available botulinum neurotoxin serotypes A1, B1, and F1

Toxicon (Oxford), 2018-12, Vol.156, p.S25-S25

2018

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TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase

British journal of pharmacology, 2004-09, Vol.143 (1), p.186-192

2004

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Botulinum neurotoxin A and an engineered derivate targeted secretion inhibitor (TSI) A enter cells via different vesicular compartments

Journal of receptors and signal transduction, 2016-01, Vol.36 (1), p.79-88

2016

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88. Rodent- and human-derived cell-based models for the study of botulinum neurotoxin A1 (BoNT/A1)

Toxicon (Oxford), 2015-01, Vol.93, p.S27-S27

2015

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Rational modification of botulinum neurotoxin by directed scanning mutagenesis

Toxicon (Oxford), 2016-12, Vol.123, p.S55-S55

2016

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11. Functional characterization of BoNT/A subtypes

Toxicon (Oxford), 2015-01, Vol.93, p.S5-S5

2015

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Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5080-5084

2010

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Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4951-4954

2010

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6370-6374

2010

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6370-6374

2010

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Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4653-4656

2010

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The Expanding Therapeutic Utility of Botulinum Neurotoxins

Replacement of the Mouse LD50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

hiPSC-Derived Neurons Provide a Robust and Physiologically Relevant In Vitro Platform to Test Botulinum Neurotoxins

Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity

Tissue Distribution Profiles of the Human TRPM Cation Channel Family

A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

Development of a cell-based assay to replace LD50 for botulinum toxin A1

Replacement of the Mouse LD[sub.50] Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

TRPM2 Is Elevated in the tMCAO Stroke Model, Transcriptionally Regulated, and Functionally Expressed in C13 Microglia

Use of high-content imaging in botulinum toxin research

Translational value of hiPSC-derived models for botulinum neurotoxin research

Replacement of the Mouse LD 50 Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

105. Effect of botulinum neurotoxin type A subtypes on guinea pig isolated ileum smooth muscle

Potency comparison in in vitro, ex vivo, and in vivo assays of commercially available botulinum neurotoxin serotypes A1, B1, and F1

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase

Botulinum neurotoxin A and an engineered derivate targeted secretion inhibitor (TSI) A enter cells via different vesicular compartments

88. Rodent- and human-derived cell-based models for the study of botulinum neurotoxin A1 (BoNT/A1)

Rational modification of botulinum neurotoxin by directed scanning mutagenesis

11. Functional characterization of BoNT/A subtypes

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor

Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor

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