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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Cell host & microbe, 2017-04, Vol.21 (4), p.455-466.e4

2017

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Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

American Journal of Physiology: Cell Physiology, 2014-05, Vol.306 (10), p.C879-C886

2014

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RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice

Endocrinology (Philadelphia), 2020-08, Vol.161 (8), p.1

2020

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Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4

Cell metabolism, 2017-05, Vol.25 (5), p.1063-1074.e3

2017

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Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

Nature communications, 2018-11, Vol.9 (1), p.4681-15, Article 4681

2018

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MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

PloS one, 2015-05, Vol.10 (5), p.e0127083-e0127083

2015

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The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice

American journal of physiology: endocrinology and metabolism, 2017-08, Vol.313 (2), p.E222-E232

2017

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Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1

PloS one, 2014-05, Vol.9 (5), p.e97675-e97675

2014

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Cell host & microbe, 2018-04, Vol.23 (4), p.570-570

2018

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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.475-484

2012

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Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice

American journal of physiology: endocrinology and metabolism, 2020-04, Vol.318 (4), p.E579-E585

2020

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Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance

Diabetes (New York, N.Y.), 2014-11, Vol.63 (11), p.3742-3747

2014

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Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

Molecular biology of the cell, 2014-04, Vol.25 (7), p.1159-1170

2014

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Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non―Small Cell Lung Cancer

Clinical cancer research, 2012-09, Vol.18 (18), p.4973-4985

2012

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NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Endocrinology (Philadelphia), 2010-12, Vol.151 (12), p.5624-5637

2010

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Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia

Scientific reports, 2017-05, Vol.7 (1), p.1578-13, Article 1578

2017

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Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Molecular biology of the cell, 2012-10, Vol.23 (20), p.4065-4078

2012

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Gut microbiota impairs insulin clearance in obese mice

Molecular metabolism (Germany), 2020-12, Vol.42, p.101067-101067, Article 101067

2020

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MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Cell reports (Cambridge), 2016-09, Vol.17 (1), p.221-232

2016

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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

PloS one, 2011-04, Vol.6 (4), p.e18552

2011

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The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors

Experimental hematology, 2008-10, Vol.36 (10), p.1266-1277

2008

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S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome

Rheumatology (Oxford, England), 2018-07, Vol.57 (7), p.1299-1304

2018

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Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer

PloS one, 2011-11, Vol.6 (11), p.e27018

2011

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Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

Biology open, 2014-04, Vol.3 (5), p.314-325

2014

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

RIPK2 Dictates Insulin Responses to Tyrosine Kinase Inhibitors in Obese Male Mice

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice

Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice

Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non―Small Cell Lung Cancer

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance

Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Gut microbiota impairs insulin clearance in obese mice

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling

The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors

S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome

Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

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