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Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy

Current cancer drug targets, 2001-08, Vol.1 (2), p.141-153

2001

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"Programmed death" in Schopenhauer's World?

Apoptosis (London), 2002-06, Vol.7 (3), p.285-285

Focher, F

2002

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Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors

Parasitology, 2009-05, Vol.136 (6), p.595-602

2009

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Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

Biochemical journal, 2002-11, Vol.368 (Pt 1), p.325-332

2002

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Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

Gene therapy, 2003-12, Vol.10 (25), p.2052-2058

2003

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Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Biochemical journal, 2000-10, Vol.351 Pt 2 (2), p.319-326

2000

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Molecular basis for the antiviral and anticancer activities of unnatural L-β-nucleosides

Expert opinion on investigational drugs, 1998-08, Vol.7 (8), p.1285-1300

1998

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Uracil-DNA glycosylases preferentially excise mispaired uracil

Biochemical journal, 1992-11, Vol.287 (3), p.1007-1010

1992

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5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies

Molecular pharmacology, 1995-06, Vol.47 (6), p.1231-1238

1995

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The control of cultural evolution has been tried, what's next?

BioEssays, 2001-08, Vol.23 (8), p.761-761

Focher, Federico

2001

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Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure−Activity Relationships and Antiherpetic Activity in Vivo

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3919-3929

2005

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Herpes simplex virus type 1 uracil-DNA glycosylase : isolation and selective inhibition by novel uracil derivatives

Biochemical journal, 1993-06, Vol.292 (3), p.883-889

1993

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SYNTHESIS AND IN VITRO ACTIVITY OF D- AND L-ENANTIOMERS OF 5-(TRIFLUOROMETHYL)URACIL NUCLEOSIDE DERIVATIVES

Nucleosides, nucleotides & nucleic acids, 2001-04, Vol.20 (4-7), p.1123-1125

2001

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Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosides

Biochimie, 1995, Vol.77 (11), p.861-867

1995

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Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis

Journal of medicinal chemistry, 2000-06, Vol.43 (13), p.2601-2607

2000

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Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-( p-n-Octylanilino)Uracil

Virology (New York, N.Y.), 1995-08, Vol.211 (1), p.307-311

1995

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Myoclonus epilepsy and ragged-red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family

Acta neurologica Scandinavica, 1993-12, Vol.88 (6), p.406-409

1993

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Lack of stereospecificity of suid pseudorabies virus thymidine kinase

Biochemical journal, 1993-09, Vol.294 ( Pt 2) (2), p.381-385

1993

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Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella

Biochemical journal, 1994-03, Vol.298 (2), p.289-294

1994

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Myoclonus epilepsy and ragged‐red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family

Acta neurologica Scandinavica, 1993-12, Vol.88 (6), p.406-409

1993

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Some 6-Aza-5-substituted-2′-deoxyuridines Show Potent and Selective Inhibition of Herpes Simplex Virus Type 1 Thymidine Kinase

Nucleosides & nucleotides, 1998-01, Vol.17 (1-3), p.187-206

1998

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Enzymes of DNA Metabolism in a Patient with the Wiedemann-Rautenstrauch Progeroid Syndrome

Annals of the New York Academy of Sciences, 1992-11, Vol.663 (1), p.440-441

1992

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The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line

AIDS research and human retroviruses, 2006-10, Vol.22 (10), p.960-967

2006

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Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2′-azido-2′-deoxynucleosides

Biochemical pharmacology, 2004-08, Vol.68 (4), p.711-718

2004

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DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells

Anticancer research, 1992-07, Vol.12 (4), p.1099

1992

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Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy

"Programmed death" in Schopenhauer's World?

Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Molecular basis for the antiviral and anticancer activities of unnatural L-β-nucleosides

Uracil-DNA glycosylases preferentially excise mispaired uracil

5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies

The control of cultural evolution has been tried, what's next?

Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure−Activity Relationships and Antiherpetic Activity in Vivo

Herpes simplex virus type 1 uracil-DNA glycosylase : isolation and selective inhibition by novel uracil derivatives

SYNTHESIS AND IN VITRO ACTIVITY OF D- AND L-ENANTIOMERS OF 5-(TRIFLUOROMETHYL)URACIL NUCLEOSIDE DERIVATIVES

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural l-β-nucleosides

Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis

Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-( p-n-Octylanilino)Uracil

Myoclonus epilepsy and ragged-red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family

Lack of stereospecificity of suid pseudorabies virus thymidine kinase

Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella

Myoclonus epilepsy and ragged‐red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family

Some 6-Aza-5-substituted-2′-deoxyuridines Show Potent and Selective Inhibition of Herpes Simplex Virus Type 1 Thymidine Kinase

Enzymes of DNA Metabolism in a Patient with the Wiedemann-Rautenstrauch Progeroid Syndrome

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2′-azido-2′-deoxynucleosides

DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells

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