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Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer

Clinical and experimental pharmacology & physiology, 2010-04, Vol.37 (4), p.403-409

2010

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Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

Molecular pharmacology, 2009-07, Vol.76 (1), p.105-112

2009

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Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors

Bioorganic & medicinal chemistry, 2010, Vol.18 (1), p.292-304

2010

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Synthesis and Pharmacological Evaluation of N-(3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a Potent Antimitotic Agent

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.179-200

2011

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Increased absolute magnitude of gamma synchrony in first-episode psychosis

Schizophrenia research, 2008-10, Vol.105 (1), p.262-271

2008

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Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.636

2009

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UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Molecular cancer therapeutics, 2009-01, Vol.8 (1), p.36-44

2009

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Emotion-elicited gamma synchrony in patients with first-episode schizophrenia: a neural correlate of social cognition outcomes

Journal of psychiatry & neuroscience, 2009-07, Vol.34 (4), p.303-313

2009

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Spatio-temporal EEG waves in first episode schizophrenia

Clinical neurophysiology, 2009-09, Vol.120 (9), p.1667-1682

2009

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Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5274-5279

2005

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Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci

Applied and Environmental Microbiology, 2009-02, Vol.75 (3), p.872-874

2009

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AqF026 Is a Pharmacologic Agonist of the Water Channel Aquaporin-1

Journal of the American Society of Nephrology, 2013-07, Vol.24 (7), p.1045-1052

2013

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Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia

Schizophrenia research, 2007-02, Vol.90 (1), p.284-294

2007

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General and social cognition in first episode schizophrenia: Identification of separable factors and prediction of functional outcome using the IntegNeuro test battery

Schizophrenia research, 2008-02, Vol.99 (1), p.182-191

2008

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Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2420-2423

1993

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An acyl-iminium ion cyclization route to a novel conformationally restricted dipeptide mimic: applications to angiotensin-converting enzyme inhibition

Journal of the American Chemical Society, 1987-12, Vol.109 (25), p.7914-7915

1987

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3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents

Bioorganic & medicinal chemistry, 2010-05, Vol.18 (9), p.3270-3278

2010

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THE CONTRIBUTION OF ANXIETY TO FMRI IN FIRST EPISODE SCHIZOPHRENIA

Schizophrenia research, 2010-04, Vol.117 (2), p.239-239

2010

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Event-related potential correlates of depression, insight and negative symptoms in males with recent-onset psychosis

Clinical neurophysiology, 2006-08, Vol.117 (8), p.1715-1727

2006

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Small Molecule Inhibitor of ITK Disrupts TCR Signaling and Demonstrates Anti-Tumor Efficacy

Blood, 2010-11, Vol.116 (21), p.3932-3932

2010

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UA62784; a novel inhibitor of CENP-E kinesin-like protein

Molecular cancer therapeutics, 2009-01, Vol.8 (1), p.36-44

2009

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Absolute Level of Gamma Synchrony is Increased in FirstEpisode Schizophrenia during Face Processing

Journal of experimental psychopathology, 2012-10, Vol.3 (4), p.702-723

2012

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The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Tetrahedron letters, 1990, Vol.31 (6), p.815-818

1990

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Application of conformationally restricted peptidomimetics to modeling the bound conformation of peptide antagonists with the IL-1 receptor

International journal of peptide research and therapeutics, 1998-05, Vol.5 (2-3), p.93-100

1998

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Intramolecular Wittig cyclization: a novel route to previously unknown 3-thia and 3-sulfinyl analogs of testosterone

Journal of organic chemistry, 1983-11, Vol.48 (22), p.4125-4127

Flynn, Gary A

1983

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Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer

Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors

Synthesis and Pharmacological Evaluation of N-(3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a Potent Antimitotic Agent

Increased absolute magnitude of gamma synchrony in first-episode psychosis

Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer

UA62784, a novel inhibitor of centromere protein E kinesin-like protein

Emotion-elicited gamma synchrony in patients with first-episode schizophrenia: a neural correlate of social cognition outcomes

Spatio-temporal EEG waves in first episode schizophrenia

Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes

Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci

AqF026 Is a Pharmacologic Agonist of the Water Channel Aquaporin-1

Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia

General and social cognition in first episode schizophrenia: Identification of separable factors and prediction of functional outcome using the IntegNeuro test battery

Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11

An acyl-iminium ion cyclization route to a novel conformationally restricted dipeptide mimic: applications to angiotensin-converting enzyme inhibition

3,5-Diaryl-1H-pyrazole as a molecular scaffold for the synthesis of apoptosis-inducing agents

THE CONTRIBUTION OF ANXIETY TO FMRI IN FIRST EPISODE SCHIZOPHRENIA

Event-related potential correlates of depression, insight and negative symptoms in males with recent-onset psychosis

Small Molecule Inhibitor of ITK Disrupts TCR Signaling and Demonstrates Anti-Tumor Efficacy

UA62784; a novel inhibitor of CENP-E kinesin-like protein

Absolute Level of Gamma Synchrony is Increased in FirstEpisode Schizophrenia during Face Processing

The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Application of conformationally restricted peptidomimetics to modeling the bound conformation of peptide antagonists with the IL-1 receptor

Intramolecular Wittig cyclization: a novel route to previously unknown 3-thia and 3-sulfinyl analogs of testosterone

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