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SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

The Journal of biological chemistry, 2010-03, Vol.285 (11), p.8340-8351

2010

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.63-68

2013

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Abstract 923: Pharmacological Activation of Ampk With a Direct Pan-ampk Activator Results in a Worsening of a Hf Phenotype in Mice

Circulation research, 2019-08, Vol.125 (Suppl_1)

2019

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Efficacy of telemedicine on glycaemic control in patients with type 2 diabetes: A meta-analysis

World journal of diabetes, 2021-02, Vol.12 (2), p.170-197

2021

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Hypothermia-induced QTc prolongation in non-human primates; Why you should measure body temperature in cardiovascular safety studies

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid

International journal of toxicology, 2022-08, Vol.41 (4), p.276-290

2022

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Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.128-135

2016

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Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4219-4233

2011

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Differential effects of selective versus nonselective alpha adrenergic receptor blockade on cardiovascular (CV) parameters and heart rate variability (HRV) in rats

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Blood pressure and heart rate measures: How well do pre‐clinical models translate? (681.7)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Citrate infusion produces ionic hypocalcemia, hypomagnesemia and associated cardiovascular changes in the sling-restrained beagle dog—A PK/PD analysis

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e40-e40

2013

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.767-772

2013

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Use of an in vitro contractility assay to explore cardiac contractility changes observed in an in vivo cardiovascular study

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e21-e21

2013

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Effects of selective versus nonselective alpha adrenergic receptor blockade on cardiovascular parameters, body temperature and sympathetic tone in rats

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e47-e47

2013

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-[gamma]

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.767-772

2013

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Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-[gamma]

Journal of medicinal chemistry, 2013-03, Vol.54 ((12) ; 06, 2011)

2013

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Review of companies and drug classes in the 2007-2011 antihypertensive patent literature

Pharmaceutical patent analyst, 2012-03, Vol.1 (1), p.45-64

2012

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Optimization of triazole-based TGR5 agonists towards orally available agentsElectronic supplementary information (ESI) available: Detailed experimental procedures for synthesis of compounds 4, 10-18, a dataset of compounds 2-9 used for a plot in Fig. 2, and protocols for cAMP assays, human whole blood assay, and in vivo dog PK studies. See DOI: 10.1039/c2md20174g

2012-12

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Sarafotoxin S6c Elicits a Non-ETA or Non-ETB-Mediated Pressor Response in the Pithed Rat

Journal of cardiovascular pharmacology, 1995, Vol.26 Suppl 3, p.S219-221

1995

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Sarafotoxin S6c Elicits a Non-ETA or Non-ETB-Mediated Pressor Response in the Pithed Rat

Journal of cardiovascular pharmacology, 1995, Vol.26 Suppl 3, p.S219-221

1995

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How Are Students Solving Familiar and Unfamiliar Organic Chemistry Mechanism Questions in a New Curriculum?

Journal of chemical education, 2018-09, Vol.95 (9), p.1451-1467

2018

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The impact of burnout on paediatric nurses' attitudes about patient safety in the acute hospital setting: A systematic review

Journal of pediatric nursing, 2024-09, Vol.78, p.e82-e89

2024

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SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Abstract 923: Pharmacological Activation of Ampk With a Direct Pan-ampk Activator Results in a Worsening of a Hf Phenotype in Mice

Optimization of triazole-based TGR5 agonists towards orally available agents

Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

Efficacy of telemedicine on glycaemic control in patients with type 2 diabetes: A meta-analysis

Hypothermia-induced QTc prolongation in non-human primates; Why you should measure body temperature in cardiovascular safety studies

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid

Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Differential effects of selective versus nonselective alpha adrenergic receptor blockade on cardiovascular (CV) parameters and heart rate variability (HRV) in rats

Blood pressure and heart rate measures: How well do pre‐clinical models translate? (681.7)

Citrate infusion produces ionic hypocalcemia, hypomagnesemia and associated cardiovascular changes in the sling-restrained beagle dog—A PK/PD analysis

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

Use of an in vitro contractility assay to explore cardiac contractility changes observed in an in vivo cardiovascular study

Effects of selective versus nonselective alpha adrenergic receptor blockade on cardiovascular parameters, body temperature and sympathetic tone in rats

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-[gamma]

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-[gamma]

Review of companies and drug classes in the 2007-2011 antihypertensive patent literature

Sarafotoxin S6c Elicits a Non-ETA or Non-ETB-Mediated Pressor Response in the Pithed Rat

Sarafotoxin S6c Elicits a Non-ETA or Non-ETB-Mediated Pressor Response in the Pithed Rat

How Are Students Solving Familiar and Unfamiliar Organic Chemistry Mechanism Questions in a New Curriculum?

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

The impact of burnout on paediatric nurses' attitudes about patient safety in the acute hospital setting: A systematic review

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