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Glutathione transferases as targets for cancer therapy

Anti-cancer agents in medicinal chemistry, 2009-09, Vol.9 (7), p.763

2009

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Differential Inducing Effect of Benzo[a]pyrene on Gene Expression and Enzyme Activity of Cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar Rats

DRUG METABOLISM AND PHARMACOKINETICS, 2012, Vol.27 (6), p.640-652

2012

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Inhibition of Cytochrome P450 2C8-mediated Drug Metabolism by the Flavonoid Diosmetin

DRUG METABOLISM AND PHARMACOKINETICS, 2011-01, Vol.26 (6), p.559-568

2011

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Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes

PloS one, 2013-04, Vol.8 (4), p.e61983

2013

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Diagnostic Value of Plasma Cystatin C as a Glomerular Filtration Marker in Decompensated Liver Cirrhosis

Clinical chemistry (Baltimore, Md.), 2002-06, Vol.48 (6), p.850-858

2002

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Flavonoids Diosmetin and Hesperetin are Potent Inhibitors of Cytochrome P450 2C9-mediated Drug Metabolism in vitro

Drug metabolism and pharmacokinetics, 2010-01, Vol.25 (5), p.466-476

2010

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Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity

Life sciences (1973), 2003-05, Vol.72 (24), p.2741-2750

2003

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Neurotrophins Rescue Cerebellar Granule Neurons from Oxidative Stress‐Mediated Apoptotic Death: Selective Involvement of Phosphatidylinositol 3‐Kinase and the Mitogen‐Activated Protein Kinase Pathway

Journal of neurochemistry, 1998-05, Vol.70 (5), p.1859-1868

1998

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Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

Clinical cancer research, 2005-02, Vol.11 (4), p.1608-1617

2005

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Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone

Bioorganic & medicinal chemistry, 2003-11, Vol.11 (22), p.4749-4759

2003

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Oxidative stress induces cytotoxicity during rejection reaction in the compound ascidian Botryllus schlosseri

Comparative biochemistry and physiology. Toxicology & pharmacology, 2002-11, Vol.133 (3), p.411-418

2002

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Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes

Biochemical pharmacology, 2008-03, Vol.75 (6), p.1426-1437

2008

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Melatonin maintains glutathione homeostasis in kainic acid‐exposed rat brain tissues

The FASEB journal, 1997-12, Vol.11 (14), p.1309-1315

1997

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Flavonoids Diosmetin and Hesperetin are Potent Inhibitors of Cytochrome P450 2C9-mediated Drug Metabolism in vitro

DRUG METABOLISM AND PHARMACOKINETICS, 2010, Vol.25 (5), p.466-476

2010

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Characterization of Intrinsic Sympathomimetic Activity of Carteolol in Rat Cardiovascular Preparations

Journal of Pharmacological Sciences, 2004, Vol.95(1), pp.115-123

2004

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Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B

Journal of peptide science, 2006-07, Vol.12 (7), p.455-461

2006

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Fluvoxamine pharmacokinetics in healthy elderly subjects and elderly patients with chronic heart failure

British journal of clinical pharmacology, 2010-03, Vol.69 (3), p.279-286

2010

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Cytochrome P450 1A2 is a Major Determinant of Lidocaine Metabolism in Vivo: Effects of Liver Function

Clinical pharmacology and therapeutics, 2004-01, Vol.75 (1), p.80-88

2004

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Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy

The FEBS journal, 2005-03, Vol.272 (5), p.1124-1135

2005

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In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes

Biochemical pharmacology, 2008-09, Vol.76 (6), p.784-795

2008

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Synthesis and Preliminary in Vitro Biological Evaluation of 4-[(4-Hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-Mercaptophenol Derivative Designed As a Novel Bifunctional Antimelanoma Agent

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4973-4976

2009

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Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.303-309

2008

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Comparison of the binding affinity of CGP-12177A at recombinant rat α1D-adrenoceptors expressed in BHK-21 cell membranes and α1-adrenoceptors present in rat cerebral cortex membranes

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.303-309

2008

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Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.269-275

2008

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Carteolol, a non-conventional partial agonist of β1-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at α1-adrenoceptors

European journal of pharmacology, 2008-08, Vol.590 (1-3), p.269-275

2008

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Glutathione transferases as targets for cancer therapy

Differential Inducing Effect of Benzo[a]pyrene on Gene Expression and Enzyme Activity of Cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar Rats

Inhibition of Cytochrome P450 2C8-mediated Drug Metabolism by the Flavonoid Diosmetin

Severe liver cirrhosis markedly reduces AhR-mediated induction of cytochrome P450 in rats by decreasing the transcription of target genes

Diagnostic Value of Plasma Cystatin C as a Glomerular Filtration Marker in Decompensated Liver Cirrhosis

Flavonoids Diosmetin and Hesperetin are Potent Inhibitors of Cytochrome P450 2C9-mediated Drug Metabolism in vitro

Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity

Neurotrophins Rescue Cerebellar Granule Neurons from Oxidative Stress‐Mediated Apoptotic Death: Selective Involvement of Phosphatidylinositol 3‐Kinase and the Mitogen‐Activated Protein Kinase Pathway

Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone

Oxidative stress induces cytotoxicity during rejection reaction in the compound ascidian Botryllus schlosseri

Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes

Melatonin maintains glutathione homeostasis in kainic acid‐exposed rat brain tissues

Flavonoids Diosmetin and Hesperetin are Potent Inhibitors of Cytochrome P450 2C9-mediated Drug Metabolism in vitro

Characterization of Intrinsic Sympathomimetic Activity of Carteolol in Rat Cardiovascular Preparations

Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B

Fluvoxamine pharmacokinetics in healthy elderly subjects and elderly patients with chronic heart failure

Cytochrome P450 1A2 is a Major Determinant of Lidocaine Metabolism in Vivo: Effects of Liver Function

Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber's hereditary optic neuropathy

In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes

Synthesis and Preliminary in Vitro Biological Evaluation of 4-[(4-Hydroxyphenyl)sulfanyl]but-3-en-2-one, a 4-Mercaptophenol Derivative Designed As a Novel Bifunctional Antimelanoma Agent

Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes

Comparison of the binding affinity of CGP-12177A at recombinant rat α1D-adrenoceptors expressed in BHK-21 cell membranes and α1-adrenoceptors present in rat cerebral cortex membranes

Carteolol, a non-conventional partial agonist of beta(1)-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at alpha(1)-adrenoceptors

Carteolol, a non-conventional partial agonist of β1-adrenoceptors, relaxes phenylephrine-constricted rat aorta through antagonism at α1-adrenoceptors

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