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Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice

Blood advances, 2024-08, Vol.8 (15), p.3906-3913

2024

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Abstract 156: Pyruvate Kinase M2 Regulates SNAP23-mediated Platelet Granule Exocytosis, Neutrophil Extracellular Traps Formation And Experimental Venous Thrombosis

Arteriosclerosis, thrombosis, and vascular biology, 2024-05, Vol.44 (Suppl_1)

2024

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Abstract 122: Deletion Of Pyruvate Dehydrogenase Kinases Reduces Susceptibility To Experimental Venous Thrombosis By Limiting Glycolysis In Neutrophils

Arteriosclerosis, thrombosis, and vascular biology, 2024-05, Vol.44 (Suppl_1)

2024

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Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI-Stimulated Human Platelets-Brief Report

Arteriosclerosis, thrombosis, and vascular biology, 2024-02, Vol.44 (2), p.409-416

2024

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Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?

Cardiovascular research, 2023-11, Vol.119 (15), p.2497-2507

2023

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Abstract 19037: Metabolomics Reveals Aerobic Glycolysis and 1-Carbon Metabolism as Major Metabolic Signature During Human Platelet Activation

Circulation (New York, N.Y.), 2023-11, Vol.148 (Suppl_1)

2023

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Platelets from Ehlers-Danlos Syndrome Patients Exhibit Reduced GPVI Levels and Impaired Integrin αIIbβ3 inside-out Signaling

Blood, 2023-11, Vol.142 (Supplement 1), p.1191-1191

2023

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Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis

Journal of thrombosis and haemostasis, 2023-08, Vol.21 (8), p.2163-2174

2023

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Characterization of bleeding symptoms in Ehlers–Danlos syndrome

Journal of thrombosis and haemostasis, 2023-07, Vol.21 (7), p.1824-1830

2023

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Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Blood advances, 2023-06, Vol.7 (11), p.2347-2359

2023

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Abstract 129: Bleeding Diathesis In Ehlers-danlos Syndrome Patients Is Caused By Impaired Platelet Inside-out Signaling And Integrin αIIbβ3 Activation

Arteriosclerosis, thrombosis, and vascular biology, 2023-05, Vol.43 (Suppl_1)

2023

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Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke

Journal of thrombosis and haemostasis, 2022-04, Vol.20 (4), p.790-793

2022

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PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

Blood, 2022-02, Vol.139 (8), p.1234-1245

2022

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The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Blood, 2021-03, Vol.137 (12), p.1658-1668

2021

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Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice

Blood, 2020-03, Vol.135 (11), p.857-861

2020

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Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis

Scientific reports, 2019-11, Vol.9 (1), p.17210-14, Article 17210

2019

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Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

Blood, 2019-11, Vol.134 (Supplement_1), p.1056-1056

2019

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A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes

Current pharmaceutical design, 2019-01, Vol.25 (38), p.4063-4084

2019

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Non-genomic effects of nuclear receptors: insights from the anucleate platelet

Cardiovascular research, 2018-04, Vol.114 (5), p.645-655

2018

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RXR Ligands Negatively Regulate Thrombosis and Hemostasis

Arteriosclerosis, thrombosis, and vascular biology, 2017-05, Vol.37 (5), p.812-822

2017

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Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets

Arteriosclerosis, thrombosis, and vascular biology, 2016-12, Vol.36 (12), p.2324-2333

2016

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Pharmacological actions of nobiletin in the modulation of platelet function

British journal of pharmacology, 2015-08, Vol.172 (16), p.4133-4145

2015

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Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis

Biochemical Society transactions, 2015-06, Vol.43 (3), p.489-494

2015

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Deletion of pyruvate dehydrogenase kinases reduces susceptibility to deep vein thrombosis in mice

Abstract 156: Pyruvate Kinase M2 Regulates SNAP23-mediated Platelet Granule Exocytosis, Neutrophil Extracellular Traps Formation And Experimental Venous Thrombosis

Abstract 122: Deletion Of Pyruvate Dehydrogenase Kinases Reduces Susceptibility To Experimental Venous Thrombosis By Limiting Glycolysis In Neutrophils

Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI-Stimulated Human Platelets-Brief Report

Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?

Abstract 19037: Metabolomics Reveals Aerobic Glycolysis and 1-Carbon Metabolism as Major Metabolic Signature During Human Platelet Activation

Platelets from Ehlers-Danlos Syndrome Patients Exhibit Reduced GPVI Levels and Impaired Integrin αIIbβ3 inside-out Signaling

Mitochondrial calcium uniporter b deletion inhibits platelet function and reduces susceptibility to arterial thrombosis

Characterization of bleeding symptoms in Ehlers–Danlos syndrome

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Abstract 129: Bleeding Diathesis In Ehlers-danlos Syndrome Patients Is Caused By Impaired Platelet Inside-out Signaling And Integrin αIIbβ3 Activation

Constitutively active ADAMTS13: An emerging thrombolytic agent for acute ischemic stroke

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis

Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis

Targeting Metabolic Enzyme Pyruvate Kinase M2: A Novel Strategy to Inhibit Platelet Function and Arterial Thrombosis

A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes

Non-genomic effects of nuclear receptors: insights from the anucleate platelet

RXR Ligands Negatively Regulate Thrombosis and Hemostasis

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets

Pharmacological actions of nobiletin in the modulation of platelet function

Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis

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