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Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

The FASEB journal, 2020-01, Vol.34 (1), p.1679-1694

2020

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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

Neurobiology of disease, 2019-10, Vol.130, p.104525-104525, Article 104525

2019

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ATP13A2 (PARK9) and basal ganglia function

Frontiers in neurology, 2023, Vol.14, p.1252400-1252400

2023

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Assessment of sensorimotor function in mouse models of Parkinson's disease

Journal of visualized experiments, 2013-06 (76)

2013

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Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

PloS one, 2013-11, Vol.8 (11), p.e81426-e81426

2013

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Olfactory assays for mouse models of neurodegenerative disease

Journal of visualized experiments, 2014-08 (90), p.e51804-e51804

2014

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Farey Trees Explain Sequential Effects in Choice Response Time

Frontiers in physiology, 2021-03, Vol.12, p.611145-611145

2021

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HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease

Nature neuroscience, 2011-01, Vol.14 (1), p.85-92

2011

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Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Neurobiology of disease, 2020-07, Vol.141, p.104947-104947, Article 104947

2020

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Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein

Behavioural brain research, 2018-05, Vol.343, p.41-49

2018

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Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies

Neuropharmacology, 2022-01, Vol.202, p.108870-108870, Article 108870

2022

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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

The Journal of biological chemistry, 2003-10, Vol.278 (44), p.43628-43635

2003

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iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology

Molecular therapy. Methods & clinical development, 2023-06, Vol.29, p.185-201

2023

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CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

Neuropharmacology, 2000-04, Vol.39 (5), p.777-787

2000

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A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions

Molecular and cellular neuroscience, 2011-03, Vol.46 (3), p.597-606

2011

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Cranial and related sensorimotor impairments in rodent models of Parkinson's disease

Behavioural brain research, 2012-06, Vol.231 (2), p.317-322

2012

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Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Neurobiology of disease, 2014-09, Vol.69, p.263-275

2014

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Mechanisms of Gene-Environment Interactions in Parkinson’s Disease

Current environmental health reports, 2017-06, Vol.4 (2), p.192-199

Fleming, Sheila M.

2017

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Behavioral Outcome Measures for the Assessment of Sensorimotor Function in Animal Models of Movement Disorders

International Review of Neurobiology, 2009, Vol.89, p.57-65

Fleming, Sheila M.

2009

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Role of rodent models in advancing precision medicine for Parkinson's disease

Handbook of Clinical Neurology, 2023, Vol.193, p.3-16

2023

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Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

Behavioural brain research, 2012-05, Vol.230 (2), p.309-316

2012

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Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (27), p.11125-11130

2009

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Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

Molecular neurodegeneration, 2011-12, Vol.6 (1), p.83-83

2011

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Variable effects of chronic subcutaneous administration of rotenone on striatal histology

Journal of comparative neurology (1911), 2004-10, Vol.478 (4), p.418-426

2004

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Cognitive dysfunction and increased phosphorylated tau are associated with reduced O‐GlcNAc signaling in an aging mouse model of metabolic syndrome

Journal of neuroscience research, 2023-08, Vol.101 (8), p.1324-1344

2023

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Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

ATP13A2 (PARK9) and basal ganglia function

Assessment of sensorimotor function in mouse models of Parkinson's disease

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

Olfactory assays for mouse models of neurodegenerative disease

Farey Trees Explain Sequential Effects in Choice Response Time

HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein

Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology

CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions

Cranial and related sensorimotor impairments in rodent models of Parkinson's disease

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Mechanisms of Gene-Environment Interactions in Parkinson’s Disease

Behavioral Outcome Measures for the Assessment of Sensorimotor Function in Animal Models of Movement Disorders

Role of rodent models in advancing precision medicine for Parkinson's disease

Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

Variable effects of chronic subcutaneous administration of rotenone on striatal histology

Cognitive dysfunction and increased phosphorylated tau are associated with reduced O‐GlcNAc signaling in an aging mouse model of metabolic syndrome

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